Immunobiology, Год журнала: 2025, Номер unknown, С. 152875 - 152875
Опубликована: Янв. 1, 2025
Язык: Английский
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Сен. 8, 2022
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the joints. Microbial infection considered crucial inducer of RA. Alterations in composition intestinal bacteria individuals with preclinical and established RA suggest vital role gut microbiota immune dysfunction characteristic However, mechanisms by which dysbiosis contributes to are not fully understood. Furthermore, multiple therapies commonly used treat may alter diversity, suggesting modulating help prevent or Hence, better understanding changes accompany should aid development novel therapeutic approaches. This mini-review discusses impact pathogenesis RA, selection microbiota-related biomarkers for diagnosing provides examples cross-modulation between some drugs Some suggestions outlooks also raised, guide future research efforts.
Язык: Английский
Процитировано
120
Ageing Research Reviews, Год журнала: 2023, Номер 89, С. 101981 - 101981
Опубликована: Июнь 10, 2023
Язык: Английский
Процитировано
43
International Immunopharmacology, Год журнала: 2025, Номер 148, С. 114112 - 114112
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
2
Journal of Ethnopharmacology, Год журнала: 2022, Номер 301, С. 115839 - 115839
Опубликована: Окт. 20, 2022
Xinfeng capsule is a traditional Chinese medicine compound, which has been clinically used for more than 20 years in the treatment of rheumatoid arthritis (RA), ankylosing spondylitis, osteoarthritis and its extracurricular lesions. However, molecular role XFC RA remains unclear.This study aims to explore efficacy potential mechanism through retrospective data mining analysis, animal experiments cell experiments.The effect on clinical laboratory indexes patients was observed using techniques combined with association rule analysis random walk model. Afterwards, rat model adjuvant (AA) established Freund's complete adjuvant, followed by observation pathological changes synovial tissues ultrastructure synoviocytes. A constructed inducing fibroblast-like synoviocytes (FLSs) tumor necrosis factor-alpha (TNF-α) assess effects XFC-containing serum inflammation oxidative stress long non-coding RNA LINC00638.In mining, effectively reduced immune increase level antioxidant enzymes patients. Subsequently, showed that significantly repressed inflammation, stress, hyperplasia, cartilage destruction, while improving AA rats. diminished proliferation TNF-α-induced RA-FLSs, increased LINC00638 expression (P＜0.01), decreased interleukin-6 (IL-6), IL-17, reactive oxygen species (ROS) nitrogen (RNS) levels protein nuclear factor erythrocyte 2-related 2 (Nrf2), heme oxygenase 1 (HO-1), superoxide dismutase (SOD2) (P＜0.01). Furthermore, rescue manifested reversed silencing RA-FLSs.XFC inhibits up-regulating activating Nrf2/HO-1 pathway.
Язык: Английский
Процитировано
38
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Май 31, 2023
The aim of this study is to evaluate the effectiveness and safety curcumin in rheumatoid arthritis patients.
Язык: Английский
Процитировано
36
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Янв. 13, 2023
Macrophage polarization determines the production of cytokines that fuel initiation and evolution rheumatoid arthritis (RA). Thus, modulation macrophage might represent a potential therapeutic strategy for RA. However, coordinated macrophages in synovium synovial fluid has not been achieved thus far. Herein, we develop biomimetic ApoA-I mimetic peptide-modified neutrophil membrane-wrapped F127 polymer (R4F-NM@F127) targeted drug delivery during RA treatment. Due to high expression adhesion molecules chemokine receptors on neutrophils, membrane coating can endow nanocarrier with synovitis-targeting ability, subsequent recruitment under chemotactic effects IL-8. Moreover, R4F peptide modification further endows ability target SR-B1 receptor, which is highly expressed fluid. Long-term vivo imaging shows R4F-NM@F127 preferentially accumulates inflamed joints engulfed by macrophages. After loading anti-inflammatory celastrol (Cel), R4F-NM@F127-Cel significant reduction hepatotoxicity, effectively inhibits inflammation alleviates joint damage reprogramming polarization. our results highlight as promising option treatment
Язык: Английский
Процитировано
29
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(32), С. 38653 - 38664
Опубликована: Авг. 3, 2023
As a typical chronic inflammatory joint disease with swelling and pain syndromes, rheumatoid arthritis (RA) is closely related to articular lubrication deficiency excessive proinflammatory cytokines in its progression pathogenesis. Herein, inspired by the dual effects of improvement anti-inflammation treat RA, two novel potential therapeutic nanoagents have been developed rationally employing herbal medicine-derived carbon quantum dots (CQDs), i.e., safflower (Carthamus tinctorius L.) CQDs Angelica sinensis CQDs, yielding ultrahigh bioefficacy. In vitro experimental results show that display excellent friction reduction due their good water solubility spherical structure. Using RA rat models, it indicated significantly relieved symptoms inhibited expression cytokines, including IL-1, IL-6, TNF-α, indicating extraordinary Thus, combining lubricating bioefficacy derived from medicine an attractive strategy develop new for treatment.
Язык: Английский
Процитировано
28
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Апрель 1, 2024
Abstract Background Herbal nanoparticles are made from natural herbs/medicinal plants, their extracts, or a combination with other nanoparticle carriers. Compared to traditional herbs, herbal lead improved bioavailability, enhanced stability, and reduced toxicity. Previous research indicates that medicine nanomaterials rapidly advancing making significant progress; however, bibliometric analysis knowledge mapping for currently lacking. We performed by retrieving publications related the Web of Science Core Collection (WoSCC) database spanning 2004 2023. Data processing was using R package Bibliometrix, VOSviewers, CiteSpace. Results In total, 1876 articles were identified, originating various countries, China being primary contributing country. The number in this field increases annually. Beijing University Chinese Medicine, Shanghai Traditional Saveetha India prominent institutions domain. Journal “International Nanomedicine” has highest publications. authors these reached 8234, Yan Zhao, Yue Zhang, Huihua Qu most prolific Zhao frequently cited author. “Traditional medicine,” “drug delivery,” “green synthesis” main focal points. Themes such as synthesis,” “curcumin,” “wound healing,” “carbon dots” may represent emerging areas. Conclusions Our study findings assist identifying latest frontiers hot topics, providing valuable references scholars investigating role nanotechnology medicine. Graphical
Язык: Английский
Процитировано
8
Phytomedicine, Год журнала: 2023, Номер 118, С. 154967 - 154967
Опубликована: Июль 16, 2023
Язык: Английский
Процитировано
17
Phytotherapy Research, Год журнала: 2024, Номер 38(6), С. 2764 - 2799
Опубликована: Март 24, 2024
Abstract Rheumatoid arthritis is a chronic autoimmune inflammatory disease characterized by immune response overexpression, causing pain and swelling in the synovial joints. This condition caused auto‐reactive antibodies that attack self‐antigens due to their incapacity distinguish between self foreign molecules. Dysregulated activity within numerous signalling immunological pathways supports disease's development progression, elevating its complexity. While current treatments provide some alleviation, effectiveness accompanied variety of adverse effects are inherent conventional medications. As result, there deep‐rooted necessity investigate alternate therapeutic strategies capable neutralizing these disadvantages. Medicinal herbs display potent bioactive phytochemicals effective complementary management disease, thus generating an enormous potency for researchers delve deep into novel phytomedicine against diseases, although additional evidence understanding required terms efficacy pharmacodynamic mechanisms. literature‐based review highlights dysregulation tolerance rheumatoid arthritis, analyses pathophysiology, elucidates relevant involved, evaluates present future therapy options underscores attributes diverse array medicinal addressing this severe disease.
Язык: Английский
Процитировано
7