Pre-column Derivative HPLC and LC-Orbitrap-MS Analysis of Monosaccharides and Non-Polysaccharides in Polygonati Rhizoma DOI Creative Commons
Ling Liang, Yu Li,

Caiyun Peng

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 17, 2024

Abstract Polygonati Rhizoma, as a traditional medicinal herb, possesses pharmacological effects enhancing physical strength and immunity. In this study, systematic analysis of the monosaccharide non-polysaccharides components in Rhizoma was conducted using pre-column derivatization high-performance liquid chromatography (HPLC-DAD) coupled to electrostatic orbitrap high-resolution mass spectrometry (LC-Orbitrap-MS) techniques. The polysaccharides from were initially extracted, hydrolyzed, derivatized with 1-phenyl-3-methyl-5-pyrazolone (PMP), resulting successful detection five monosaccharides. high sensitivity specificity HPLC-DAD method confirmed. Furthermore, by comparing external standard (ESM) quantitative multi-components single-marker (QAMS) revealed that D-mannose is most abundant Rhizoma. LC-Orbitrap-MS led identification 53 compounds, including organic acids, amino amides, saponins, alkaloids, esters, others. This research provided significant data for chemical composition basis study

Язык: Английский

Polygonati Rhizoma: A review on the extraction, purification, structural characterization, biosynthesis of the main secondary metabolites and anti-aging effects DOI
Miao Pan,

Yajing Wu,

Chunyong Sun

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 327, С. 118002 - 118002

Опубликована: Март 3, 2024

Язык: Английский

Процитировано

18
Medicine and food homology substances: A review of bioactive ingredients, pharmacological effects and applications DOI

Lei Wang,

Xuecheng Zhu,

Huilin Liu

и другие.

Food Chemistry, Год журнала: 2024, Номер 463, С. 141111 - 141111

Опубликована: Сен. 6, 2024

Язык: Английский

Процитировано

17
Pharmacological properties of Polygonatum and its active ingredients for the prevention and treatment of cardiovascular diseases DOI Creative Commons

Hongyuan Lin,

Wenhui Wang,

Mengqi Peng

и другие.

Chinese Medicine, Год журнала: 2024, Номер 19(1)

Опубликована: Янв. 2, 2024

Abstract Despite continued advances in prevention and treatment strategies, cardiovascular diseases (CVDs) remain the leading cause of death worldwide, more effective therapeutic methods are urgently needed. Polygonatum is a traditional Chinese herbal medicine with variety pharmacological applications biological activities, such as antioxidant activity, anti-inflammation, antibacterial effect, immune-enhancing glucose regulation, lipid-lowering anti-atherosclerotic effects, diabetes anticancer effect. There has also been evidence to support cardioprotective effect recent years. However, up now, there lack comprehensive studies on active ingredients their pharmacotoxicological effects related diseases. Therefore, main components (including Polysaccharides, Flavonoids, Saponins) activities were firstly reviewed this paper. Furthermore, we summarized ’s preventing treating CVDs, its relevant toxicological investigations. Finally, emphasize potential CVDs.

Язык: Английский

Процитировано

14
Liposomes Enhance the Immunological Activity of Polygonatum Cyrtonema Hua Polysaccharides DOI
Dong Liu,

Tingting Hou,

Chunye Geng

и другие.

Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 113(6), С. 1572 - 1579

Опубликована: Янв. 21, 2024

Язык: Английский

Процитировано

12
A review of medicine and food homology on traditional Chinese medicine as functional food DOI
Siukan Law, Dawn Ching Tung Au

Food & medicine homology., Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
A comprehensive review on the potential applications of medicine Polygonatum species in the food sector DOI

Mi Li,

Bingzong Xie,

Lewen Li

и другие.

Food Bioscience, Год журнала: 2024, Номер 60, С. 104116 - 104116

Опубликована: Апрель 17, 2024

Язык: Английский

Процитировано

8
Accumulation mechanism of metabolite markers identified by machine learning between Qingyuan and Xiushui counties in Polygonatum cyrtonema Hua DOI Creative Commons

Qiqi Gong,

Jianfeng Yu, Zhicheng Guo

и другие.

BMC Plant Biology, Год журнала: 2024, Номер 24(1)

Опубликована: Март 6, 2024

Abstract Polygonatum cyrtonema Hua is a traditional Chinese medicinal plant acclaimed for its therapeutic potential in diabetes and various chronic diseases. Its rhizomes are the main functional parts rich secondary metabolites, such as flavonoids saponins. But their quality varies by region, posing challenges industrial application of P. . In this study, 482 metabolites were identified rhizome from Qingyuan Xiushui counties. Cluster analysis showed that samples between these two regions had distinct metabolite profiles. Machine learning methods, specifically support vector machine-recursive feature elimination random forest, utilized to further identify markers including flavonoids, phenolic acids, lignans. Comparative transcriptomics weighted gene co-expression performed uncover candidate genes CHI , UGT1 PcOMT10/11/12/13 associated with compounds. Functional assays using tobacco transient expression system revealed indeed impacted metabolic fluxes phenylpropanoid pathway phenylpropanoid-related chrysoeriol-6,8-di-C-glucoside, syringaresinol-4'-O-glucopyranosid, 1-O-Sinapoyl-D-glucose. These findings provided valuable genetic insights engineering biosynthesis

Язык: Английский

Процитировано

6
Characterization of metabolite landscape distinguishes wild from cultivated Polygonati Rhizomes by UHPLC-Q-TOF-MS untargeted metabolomics DOI
Weitao Wang, Zhihang Zheng,

Jiangyan Chen

и другие.

Food Bioscience, Год журнала: 2023, Номер 53, С. 102574 - 102574

Опубликована: Март 24, 2023

Язык: Английский

Процитировано

14
Polygonati rhizoma polysaccharides relieve exercise-induced fatigue by regulating gut microbiota DOI Creative Commons

Jing Xian,

Quanlong Chen,

Chen Zhang

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 107, С. 105658 - 105658

Опубликована: Июль 4, 2023

Polygonati rhizoma (known as Huangjing in Chinese), an edible medicinal herb with homology of medicine and food, was also commonly used food additives Asian countries to provide many health benefits. Currently, the amelioration fatigue induced by excessive exercise has become a concern. In present study, we studied anti-fatigue effect P. polysaccharides (PRP) explored its potential mechanism gut flora regulation. The molecular weight, monosaccharide composition, morphology, FT-IR analysis PRP were performed. Following intragastric administration PRP, exhaustive swimming model mice demonstrated increased time, creatine kinase malondialdehyde level, decreased lactic acid blood urine nitrogen levels. Furthermore, abundance Akkermansia, Lactobacillus, Faecalibacterium remarkably enhanced, while Streptococcus Bacteroides decreased, compared group. summary, our findings offer compelling evidence supporting beneficial effects on exercise-induced fatigue.

Язык: Английский

Процитировано

14
Polygonati Rhizoma varieties and origins traceability based on multivariate data fusion combined with an artificial intelligence classification algorithm DOI
Peng Chen, Chenghao Fei, Rao Fu

и другие.

Food Chemistry, Год журнала: 2024, Номер 460, С. 140350 - 140350

Опубликована: Июль 5, 2024

Язык: Английский

Процитировано

5