Panax ginseng and aging related disorders: A systematic review

Experimental Gerontology, Год журнала: 2022, Номер 161, С. 111731 - 111731

Опубликована: Фев. 7, 2022

Язык: Английский

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Ginsenosides from Panax ginseng as Key Modulators of NF-κB Signaling Are Powerful Anti-Inflammatory and Anticancer Agents

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6119 - 6119

Опубликована: Март 24, 2023

Nuclear factor kappa B (NF-κB) signaling pathways progress inflammation and immune cell differentiation in the host response; however, uncontrollable stimulation of NF-κB is responsible for several inflammatory illnesses regardless whether conditions are acute or chronic. Innate cells, such as macrophages, microglia, Kupffer secrete pro-inflammatory cytokines, TNF-α, IL-6, IL-1β, via activation subunits, which may lead to damage normal including neurons, cardiomyocytes, hepatocytes, alveolar cells. This results occurrence neurodegenerative disorders, cardiac infarction, liver injury, eventually systemic cancer. Recently, ginsenosides from

Язык: Английский

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Role of acetylation in doxorubicin-induced cardiotoxicity

Redox Biology, Год журнала: 2021, Номер 46, С. 102089 - 102089

Опубликована: Июль 31, 2021

As a potent chemotherapeutic agent, doxorubicin (DOX) is widely used for the treatment of variety cancers However, its clinical utility limited by dose-dependent cardiotoxicity, and pathogenesis has traditionally been attributed to formation reactive oxygen species (ROS). Accordingly, prevention DOX-induced cardiotoxicity an indispensable goal optimize therapeutic regimens reduce morbidity. Acetylation emerging important epigenetic modification regulated histone deacetylases (HDACs) acetyltransferases (HATs). Despite extensive studies molecular basis biological functions acetylation, application acetylation as target in initial stage, further are required clarify complex network improve management cardiotoxicity. In this review, we summarize pivotal HDACs HATs oxidative stress, underlying mechanisms, contributions noncoding RNAs (ncRNAs) exercise-mediated Furthermore, describe research progress related several SIRT activators HDAC inhibitors with potential value chemotherapy Collectively, comprehensive understanding specific roles recent developments doxorubicin-induced will provide improved outcomes cancer cardiovascular diseases.

Язык: Английский

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The cellular function and molecular mechanism of formaldehyde in cardiovascular disease and heart development

Journal of Cellular and Molecular Medicine, Год журнала: 2021, Номер 25(12), С. 5358 - 5371

Опубликована: Май 10, 2021

As a common air pollutant, formaldehyde is widely present in nature, industrial production and consumer products. Endogenous mainly produced through the oxidative deamination of methylamine catalysed by semicarbazide-sensitive amine oxidase (SSAO) ubiquitous human body fluids, tissues cells. Vascular endothelial cells smooth muscle are rich this formaldehyde-producing enzyme easily damaged owing to consequent cytotoxicity. Consistent with this, increasing evidence suggests that cardiovascular system stages heart development also susceptible harmful effects formaldehyde. Exposure from different sources can induce disease such as arrhythmia, myocardial infarction (MI), failure (HF) atherosclerosis (AS). In particular, long-term exposure high concentrations pregnant women more likely affect embryonic cause malformations than low Specifically, ability mouse embryos effect clearance far lower rat embryos, readily allowing its accumulation. Formaldehyde may exert toxic on inducing stress cardiomyocyte apoptosis. This review focuses current progress understanding influence underlying mechanisms development.

Язык: Английский

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New Therapeutic Approaches to and Mechanisms of Ginsenoside Rg1 against Neurological Diseases

Cells, Год журнала: 2022, Номер 11(16), С. 2529 - 2529

Опубликована: Авг. 16, 2022

Neurological diseases, including Parkinson’s disease (PD), Alzheimer’s (AD), Huntington’s (HD), stroke, cerebral infarction, ischemia-reperfusion injury, depression and, stress, have high incidence and morbidity often lead to disability. However, there is no particularly effective medication against them. Therefore, finding drugs with a suitable efficacy, low toxicity manageable effects improve the quality of life patients an urgent problem. Ginsenoside Rg1 (Rg1) main active component ginseng has variety pharmacological effects. In this review, we focused on therapeutic potential for improving neurological diseases. We introduce mechanisms in apoptosis, neuroinflammation, microRNA (miRNA) family, mitogen-activated protein kinase (MAPK) oxidative nuclear factor-κB (NF-κB), learning memory addition, can also diseases through interaction different signal pathways. The purpose review explore more in-depth ideas clinical treatment (including PD, AD, HD, ischemia–reperfusion depression, stress). expected become new method

Язык: Английский

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Ginsenoside Rc ameliorated atherosclerosis via regulating gut microbiota and fecal metabolites

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Сен. 15, 2022

Atherosclerosis (AS) and the accompanied cardiovascular diseases (CVDs) were leading cause of death worldwide. Recently, association between CVDs, gut microbiota, metabolites had aroused increasing attention. In study, we headed our investigation into underlying mechanism ginsenoside Rc (GRc), an active ingredient ginsenosides used for treatment in apolipoprotein E-deficient (ApoE −/− ) mice with high-fat diet (HFD). Seven-week-old male ApoE randomly divided four groups: normal control (NC) group, HFD GRc group (40 mg/kg/d), atorvastatin (Ato) (10 mg/kg/d). Atherosclerotic injury was evaluated by aortic lesions, serum lipid levels, inflammatory factors. The composition microbiota fecal metabolite profile analyzed using 16S rRNA sequence untargeted metabolomics, respectively. results showed that significantly alleviated HFD-induced reduced levels total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), tumor necrosis factor-α (TNF-α), interleukin (IL)-6 IL-1β, increased high-density (HFD-C) level, as well alteration composition, function, profile. also reversed change Bacteroidetes Firmicutes at phylum Muribaculaceae, Lactobacillus , Ileibacterium Bifidobacterium Faecalibaculum Oscillibacter Blautia Eubacterium_coprostanoligenes_group genus 23 key involved taurine hypotaurine metabolism, arginine biosynthesis, ATP-binding cassette (ABC) transporters, primary bile acid purine tricarboxylic (TCA) cycle, glucagon signaling pathways. Additionally, eight differential intestinal floras level associated involving atherosclerotic injury. conclusion, demonstrated ameliorated injury, regulated microbial metabolomic changes mice, suggested a potential correlation among metabolites, regarding mechanisms against AS.

Язык: Английский

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Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway

Heliyon, Год журнала: 2025, Номер 11(3), С. e42159 - e42159

Опубликована: Янв. 23, 2025

To investigate the regulatory mechanism of Caesalpinia sappan L. ethyl acetate extract (CSEAE) on angiogenesis in atherosclerosis (AS) based miR-126/VEGF signalling pathway. Our study first screened for differentially expressed microRNAs (miRNAs) associated with AS using Gene Expression Omnibus (GEO) public database at National Center Biotechnology Information (NCBI) and R language software. Subsequently, our verified target-regulatory relationship between miR-126 vascular endothelial growth factor (VEGF) human umbilical vein cells (HUVECs) by "TargetScan" website dual-luciferase reporter assay. In cellular experiments, used cell proliferation assays flow cytometry to assess effects CSEAE-Mediated serum apoptosis HUVECs. animal HE staining, Oil Red O staining immunohistochemistry (IHC) detect plaque area/lumen area (%), lipid area/plaque (%) microvessel density (MVD) mouse aortas. addition, performed RT‒PCR, ELISA Western blot ex vivo experiments. A total 39 miRNAs were identified, among which expression level was significantly downregulated. Dual luciferase gene assay results showed that VEGF have a targeting relationship, mimic could inhibit activity wild-type vector (p value < 0.01). increased proliferative after 24-72 h treatment (p-value <0.01) decreased apoptotic HUVECs 0.01), RT‒PCR upregulated 0.01) downregulated mRNA IHC CSEAE reduced MVD aorta plaques mice aortic Moreover, analysis protein levels phosphatidyl-inositol-3-kinase (PI3K) Ser/Thr-protein kinase (AKT1) aortas, while receptor (VEGFR2) hypoxia-inducible factor-1 (HIF-1) mice. This emphasises as natural medicinal can improve migratory viability reduce maintain health arterial microenvironment, also inhibits delays formation ApoE-/- mice, suggesting therapeutic effect may be related its inhibition neovascularisation molecular

Язык: Английский

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Therapeutic Potential of Medicinal Plants and Their Phytoconstituents in Diabetes, Cancer, Infections, Cardiovascular Diseases, Inflammation and Gastrointestinal Disorders

Biomedicines, Год журнала: 2025, Номер 13(2), С. 454 - 454

Опубликована: Фев. 12, 2025

Conditions like diabetes mellitus (DM), cancer, infections, inflammation, cardiovascular diseases (CVDs), and gastrointestinal (GI) disorders continue to have a major global impact on mortality morbidity. Medicinal plants been used since ancient times in ethnomedicine (e.g., Ayurveda, Unani, Traditional Chinese Medicine, European Medicine) for the treatment of wide range disorders. Plants are rich source diverse phytoconstituents with antidiabetic, anticancer, antimicrobial, antihypertensive, antioxidant, antihyperlipidemic, cardioprotective, immunomodulatory, and/or anti-inflammatory activities. This review focuses 35 most commonly reported these disorders, particular emphasis their traditional uses, phytoconstituent contents, pharmacological properties, modes action. Active phytomolecules therapeutic potential include cucurbitane triterpenoids, diosgenin, limonoids (azadiradione gedunin), which exhibit antidiabetic triterpenoids specifically activating Glucose Transporter Type 4 (GLUT4) translocation. Capsaicin curcumin demonstrate anticancer activity by deactivating NF-κB arresting cell cycle G2 phase. Antimicrobial activities observed piperine, reserpine, berberine, dictamnine, chelerythrine, allitridin, latter two triggering bacterial lysis. Quercetin, catechin, genistein suppressing CD8+ cytotoxic T function. Ginsenoside Rg1 ginsenoside Rg3 treating diseases, PPARα promoter, PI3K/Akt pathway. In contrast, ternatin, tannins, quercitrin regulating arachidonic acid metabolism cyclooxygenase (COX) lipoxygenase activity. Further studies warranted fully investigate clinical benefits phytoconstituents, as well elucidate underlying molecular mechanisms

Язык: Английский

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New mechanisms of ginseng saponin-mediated anti-inflammatory action via targeting canonical inflammasome signaling pathways

Journal of Ethnopharmacology, Год журнала: 2021, Номер 278, С. 114292 - 114292

Опубликована: Июнь 3, 2021

Язык: Английский

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Nicotine: Regulatory roles and mechanisms in atherosclerosis progression

Food and Chemical Toxicology, Год журнала: 2021, Номер 151, С. 112154 - 112154

Опубликована: Март 25, 2021

Язык: Английский

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