Panax ginseng and aging related disorders: A systematic review

Experimental Gerontology, Journal Year: 2022, Volume and Issue: 161, P. 111731 - 111731

Published: Feb. 7, 2022

Language: Английский

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Role of acetylation in doxorubicin-induced cardiotoxicity

Redox Biology, Journal Year: 2021, Volume and Issue: 46, P. 102089 - 102089

Published: July 31, 2021

As a potent chemotherapeutic agent, doxorubicin (DOX) is widely used for the treatment of variety cancers However, its clinical utility limited by dose-dependent cardiotoxicity, and pathogenesis has traditionally been attributed to formation reactive oxygen species (ROS). Accordingly, prevention DOX-induced cardiotoxicity an indispensable goal optimize therapeutic regimens reduce morbidity. Acetylation emerging important epigenetic modification regulated histone deacetylases (HDACs) acetyltransferases (HATs). Despite extensive studies molecular basis biological functions acetylation, application acetylation as target in initial stage, further are required clarify complex network improve management cardiotoxicity. In this review, we summarize pivotal HDACs HATs oxidative stress, underlying mechanisms, contributions noncoding RNAs (ncRNAs) exercise-mediated Furthermore, describe research progress related several SIRT activators HDAC inhibitors with potential value chemotherapy Collectively, comprehensive understanding specific roles recent developments doxorubicin-induced will provide improved outcomes cancer cardiovascular diseases.

Language: Английский

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The cellular function and molecular mechanism of formaldehyde in cardiovascular disease and heart development

Journal of Cellular and Molecular Medicine, Journal Year: 2021, Volume and Issue: 25(12), P. 5358 - 5371

Published: May 10, 2021

As a common air pollutant, formaldehyde is widely present in nature, industrial production and consumer products. Endogenous mainly produced through the oxidative deamination of methylamine catalysed by semicarbazide-sensitive amine oxidase (SSAO) ubiquitous human body fluids, tissues cells. Vascular endothelial cells smooth muscle are rich this formaldehyde-producing enzyme easily damaged owing to consequent cytotoxicity. Consistent with this, increasing evidence suggests that cardiovascular system stages heart development also susceptible harmful effects formaldehyde. Exposure from different sources can induce disease such as arrhythmia, myocardial infarction (MI), failure (HF) atherosclerosis (AS). In particular, long-term exposure high concentrations pregnant women more likely affect embryonic cause malformations than low Specifically, ability mouse embryos effect clearance far lower rat embryos, readily allowing its accumulation. Formaldehyde may exert toxic on inducing stress cardiomyocyte apoptosis. This review focuses current progress understanding influence underlying mechanisms development.

Language: Английский

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New Therapeutic Approaches to and Mechanisms of Ginsenoside Rg1 against Neurological Diseases

Cells, Journal Year: 2022, Volume and Issue: 11(16), P. 2529 - 2529

Published: Aug. 16, 2022

Neurological diseases, including Parkinson’s disease (PD), Alzheimer’s (AD), Huntington’s (HD), stroke, cerebral infarction, ischemia-reperfusion injury, depression and, stress, have high incidence and morbidity often lead to disability. However, there is no particularly effective medication against them. Therefore, finding drugs with a suitable efficacy, low toxicity manageable effects improve the quality of life patients an urgent problem. Ginsenoside Rg1 (Rg1) main active component ginseng has variety pharmacological effects. In this review, we focused on therapeutic potential for improving neurological diseases. We introduce mechanisms in apoptosis, neuroinflammation, microRNA (miRNA) family, mitogen-activated protein kinase (MAPK) oxidative nuclear factor-κB (NF-κB), learning memory addition, can also diseases through interaction different signal pathways. The purpose review explore more in-depth ideas clinical treatment (including PD, AD, HD, ischemia–reperfusion depression, stress). expected become new method

Language: Английский

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Ginsenoside Rc ameliorated atherosclerosis via regulating gut microbiota and fecal metabolites

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 15, 2022

Atherosclerosis (AS) and the accompanied cardiovascular diseases (CVDs) were leading cause of death worldwide. Recently, association between CVDs, gut microbiota, metabolites had aroused increasing attention. In study, we headed our investigation into underlying mechanism ginsenoside Rc (GRc), an active ingredient ginsenosides used for treatment in apolipoprotein E-deficient (ApoE −/− ) mice with high-fat diet (HFD). Seven-week-old male ApoE randomly divided four groups: normal control (NC) group, HFD GRc group (40 mg/kg/d), atorvastatin (Ato) (10 mg/kg/d). Atherosclerotic injury was evaluated by aortic lesions, serum lipid levels, inflammatory factors. The composition microbiota fecal metabolite profile analyzed using 16S rRNA sequence untargeted metabolomics, respectively. results showed that significantly alleviated HFD-induced reduced levels total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), tumor necrosis factor-α (TNF-α), interleukin (IL)-6 IL-1β, increased high-density (HFD-C) level, as well alteration composition, function, profile. also reversed change Bacteroidetes Firmicutes at phylum Muribaculaceae, Lactobacillus , Ileibacterium Bifidobacterium Faecalibaculum Oscillibacter Blautia Eubacterium_coprostanoligenes_group genus 23 key involved taurine hypotaurine metabolism, arginine biosynthesis, ATP-binding cassette (ABC) transporters, primary bile acid purine tricarboxylic (TCA) cycle, glucagon signaling pathways. Additionally, eight differential intestinal floras level associated involving atherosclerotic injury. conclusion, demonstrated ameliorated injury, regulated microbial metabolomic changes mice, suggested a potential correlation among metabolites, regarding mechanisms against AS.

Language: Английский

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Ginsenosides from Panax ginseng as Key Modulators of NF-κB Signaling Are Powerful Anti-Inflammatory and Anticancer Agents

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6119 - 6119

Published: March 24, 2023

Nuclear factor kappa B (NF-κB) signaling pathways progress inflammation and immune cell differentiation in the host response; however, uncontrollable stimulation of NF-κB is responsible for several inflammatory illnesses regardless whether conditions are acute or chronic. Innate cells, such as macrophages, microglia, Kupffer secrete pro-inflammatory cytokines, TNF-α, IL-6, IL-1β, via activation subunits, which may lead to damage normal including neurons, cardiomyocytes, hepatocytes, alveolar cells. This results occurrence neurodegenerative disorders, cardiac infarction, liver injury, eventually systemic cancer. Recently, ginsenosides from

Language: Английский

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Ginsenoside Rh2(S) maintains cytoskeleton homeostasis and inhibits pyroptosis to resist cisplatin-induced cardiotoxicity through FGFR1/HRAS axis

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156425 - 156425

Published: Jan. 24, 2025

Language: Английский

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Therapeutic Potential of Medicinal Plants and Their Phytoconstituents in Diabetes, Cancer, Infections, Cardiovascular Diseases, Inflammation and Gastrointestinal Disorders

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 454 - 454

Published: Feb. 12, 2025

Conditions like diabetes mellitus (DM), cancer, infections, inflammation, cardiovascular diseases (CVDs), and gastrointestinal (GI) disorders continue to have a major global impact on mortality morbidity. Medicinal plants been used since ancient times in ethnomedicine (e.g., Ayurveda, Unani, Traditional Chinese Medicine, European Medicine) for the treatment of wide range disorders. Plants are rich source diverse phytoconstituents with antidiabetic, anticancer, antimicrobial, antihypertensive, antioxidant, antihyperlipidemic, cardioprotective, immunomodulatory, and/or anti-inflammatory activities. This review focuses 35 most commonly reported these disorders, particular emphasis their traditional uses, phytoconstituent contents, pharmacological properties, modes action. Active phytomolecules therapeutic potential include cucurbitane triterpenoids, diosgenin, limonoids (azadiradione gedunin), which exhibit antidiabetic triterpenoids specifically activating Glucose Transporter Type 4 (GLUT4) translocation. Capsaicin curcumin demonstrate anticancer activity by deactivating NF-κB arresting cell cycle G2 phase. Antimicrobial activities observed piperine, reserpine, berberine, dictamnine, chelerythrine, allitridin, latter two triggering bacterial lysis. Quercetin, catechin, genistein suppressing CD8+ cytotoxic T function. Ginsenoside Rg1 ginsenoside Rg3 treating diseases, PPARα promoter, PI3K/Akt pathway. In contrast, ternatin, tannins, quercitrin regulating arachidonic acid metabolism cyclooxygenase (COX) lipoxygenase activity. Further studies warranted fully investigate clinical benefits phytoconstituents, as well elucidate underlying molecular mechanisms

Language: Английский

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New mechanisms of ginseng saponin-mediated anti-inflammatory action via targeting canonical inflammasome signaling pathways

Journal of Ethnopharmacology, Journal Year: 2021, Volume and Issue: 278, P. 114292 - 114292

Published: June 3, 2021

Language: Английский

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Nicotine: Regulatory roles and mechanisms in atherosclerosis progression

Food and Chemical Toxicology, Journal Year: 2021, Volume and Issue: 151, P. 112154 - 112154

Published: March 25, 2021

Language: Английский

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