Pharmacology of bioactive compounds from plant extracts for improving non-alcoholic fatty liver disease through endoplasmic reticulum stress modulation: A comprehensive review DOI Creative Commons

Liying Huang,

Liping Tan,

Zhuo Lv

и другие.

Heliyon, Год журнала: 2024, Номер 10(3), С. e25053 - e25053

Опубликована: Янв. 23, 2024

Abstract

Background

Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic condition with significant clinical implications. Emerging research indicates endoplasmic reticulum (ER) stress as critical pathogenic factor governing inflammatory responses, lipid metabolism and insulin signal transduction in patients NAFLD. ER stress-associated activation of multiple pathways, including the unfolded protein response, disrupts homeostasis substantially contributes to NAFLD development progression. Targeting for function enhancement presents an innovative therapeutic strategy. Notably, natural bioactive compounds plant extracts have shown potential treating by reducing level marker proteins mitigating inflammation, de novo lipogenesis. However, owing limited comprehensive reviews, effectiveness pharmacology these remain uncertain.

Objectives

To address abovementioned challenges, current review categorizes chemical structures properties into flavonoids, phenols, terpenoids, glycosides, lipids quinones examines their ameliorative under stress.

Methods

This systematically analyses literature on interactions from molecular targets stress, providing holistic view therapy.

Results

Bioactive may improve alleviating stress; synthesis, oxidative apoptosis enhancing acid metabolism. provides multifaceted approach

Conclusion

underscores role this condition. The mechanisms which interact provide basis further exploration management.

Язык: Английский

Epigallocatechin gallate alleviates Non-alcoholic fatty liver disease through the inhibition of the expression and activity of Dipeptide kinase 4 DOI

Mingfeng Yang,

Ruike Yan,

Ruohe Sha

и другие.

Clinical Nutrition, Год журнала: 2024, Номер 43(8), С. 1769 - 1780

Опубликована: Июнь 19, 2024

Язык: Английский

Процитировано

5

Multi-omics joint analysis reveals that the Miao medicine Yindanxinnaotong formula attenuates non-alcoholic fatty liver disease DOI
Lei Huang, Qing Rao,

Chaoyan Wang

и другие.

Phytomedicine, Год журнала: 2024, Номер 135, С. 156026 - 156026

Опубликована: Сен. 21, 2024

Язык: Английский

Процитировано

5

Rutin ameliorate PFOA induced renal damage by reducing oxidative stress and improving lipid metabolism DOI

Xinzhuang Ma,

Xijuan Ren,

Xuemin Zhang

и другие.

The Journal of Nutritional Biochemistry, Год журнала: 2023, Номер 123, С. 109501 - 109501

Опубликована: Окт. 25, 2023

Язык: Английский

Процитировано

12

Brain–body communication in metabolic control DOI Creative Commons
Alessandro Furlan, Paul Petrus

Trends in Endocrinology and Metabolism, Год журнала: 2023, Номер 34(12), С. 813 - 822

Опубликована: Сен. 14, 2023

Energy homeostasis is achieved by the coordinated action of metabolic organs.The peripheral nervous system innervates organs, connects them with brain, and plays an important role in controlling energy homeostasis.Brain–body communication timed molecular clocks circadian rhythms.Brain–body coordination metabolism influenced cognition demographic aspects. A thorough understanding mechanisms needed to prevent treat morbidities. While contribution organs such as liver, muscle, adipose tissue, pancreas regulation has received wide attention, less known about interplay system. Here, we highlight systems regulating beyond classic hypothalamic endocrine signaling models discuss rhythms, higher brain regions, sociodemographic variables equation. We infer that interdisciplinary approaches are key conceptually advancing current research frontier devising innovative therapies disease. 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Язык: Английский

Процитировано

11

Pharmacology of bioactive compounds from plant extracts for improving non-alcoholic fatty liver disease through endoplasmic reticulum stress modulation: A comprehensive review DOI Creative Commons

Liying Huang,

Liping Tan,

Zhuo Lv

и другие.

Heliyon, Год журнала: 2024, Номер 10(3), С. e25053 - e25053

Опубликована: Янв. 23, 2024

Abstract

Background

Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic condition with significant clinical implications. Emerging research indicates endoplasmic reticulum (ER) stress as critical pathogenic factor governing inflammatory responses, lipid metabolism and insulin signal transduction in patients NAFLD. ER stress-associated activation of multiple pathways, including the unfolded protein response, disrupts homeostasis substantially contributes to NAFLD development progression. Targeting for function enhancement presents an innovative therapeutic strategy. Notably, natural bioactive compounds plant extracts have shown potential treating by reducing level marker proteins mitigating inflammation, de novo lipogenesis. However, owing limited comprehensive reviews, effectiveness pharmacology these remain uncertain.

Objectives

To address abovementioned challenges, current review categorizes chemical structures properties into flavonoids, phenols, terpenoids, glycosides, lipids quinones examines their ameliorative under stress.

Methods

This systematically analyses literature on interactions from molecular targets stress, providing holistic view therapy.

Results

Bioactive may improve alleviating stress; synthesis, oxidative apoptosis enhancing acid metabolism. provides multifaceted approach

Conclusion

underscores role this condition. The mechanisms which interact provide basis further exploration management.

Язык: Английский

Процитировано

4