Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans DOI Creative Commons
Janitza L. Montalvo‐Ortiz, Joel Gelernter, Zhongshan Cheng

и другие.

Translational Psychiatry, Год журнала: 2022, Номер 12(1)

Опубликована: Фев. 17, 2022

Abstract Posttraumatic stress disorder (PTSD) is a chronic and disabling psychiatric prevalent in military veterans. Epigenetic mechanisms have been implicated the etiology of PTSD, with DNA methylation being most studied to identify novel molecular biomarkers associated this disorder. We performed one largest single-sample epigenome-wide association studies (EWAS) PTSD date. Our sample included 1135 male European–American U.S. veterans who participated National Health Resilience Veterans Study (NHRVS). was collected from saliva samples Illumina HumanMethylation EPIC BeadChip used for analysis. assessed using Checklist. An EWAS conducted linear regression adjusted age, cell-type proportions, first 10 principal components, smoking status. After Bonferroni correction, we identified six genome-wide significant (GWS) CpG sites past-month three CpGs lifetime ( p range = −10 –10 −8 ). These map genes involved immune function, transcription regulation, axonal guidance, cell signaling, protein binding. Among these, SENP7 , which regulation has linked risk-taking behavior alcohol consumption studies, replicated an independent veteran cohort downregulated medial orbitofrontal cortex postmortem brain tissue. findings suggest potential epigenetic that may help inform pathophysiology other trauma-affected populations.

Язык: Английский

Psychiatric comorbidities in alcohol use disorder DOI
Álvaro Castillo‐Carniglia, Katherine M. Keyes, Deborah S. Hasin

и другие.

The Lancet Psychiatry, Год журнала: 2019, Номер 6(12), С. 1068 - 1080

Опубликована: Окт. 17, 2019

Язык: Английский

Процитировано

310
Post-traumatic Stress Disorder by Gender and Veteran Status DOI
Keren Lehavot,

Jodie G. Katon,

Jessica Chen

и другие.

American Journal of Preventive Medicine, Год журнала: 2017, Номер 54(1), С. e1 - e9

Опубликована: Дек. 14, 2017

Язык: Английский

Процитировано

230
Substance use and abuse, COVID-19-related distress, and disregard for social distancing: A network analysis DOI Open Access
Steven Taylor, Michelle M. Paluszek,

Geoffrey S. Rachor

и другие.

Addictive Behaviors, Год журнала: 2020, Номер 114, С. 106754 - 106754

Опубликована: Дек. 3, 2020

Язык: Английский

Процитировано

188
Diagnostic Accuracy and Acceptability of the Primary Care Posttraumatic Stress Disorder Screen for the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) Among US Veterans DOI Creative Commons
Michelle J. Bovin, Rachel Kimerling, Frank W. Weathers

и другие.

JAMA Network Open, Год журнала: 2021, Номер 4(2), С. e2036733 - e2036733

Опубликована: Фев. 4, 2021

Posttraumatic stress disorder (PTSD) is a serious mental health that can be effectively treated with empirically based practices. PTSD screening essential for identifying undetected cases and providing patients appropriate care.To determine whether the Primary Care screen Diagnostic Statistical Manual of Mental Disorders (Fifth Edition) (PC-PTSD-5) diagnostically accurate acceptable measure use in Veterans Affairs (VA) primary care clinics.This cross-sectional, diagnostic accuracy study enrolled participants from May 19, 2017, to September 26, 2018. Participants were recruited clinics across 2 VA Medical Centers. Session 1 was conducted person, session completed within 30 days via telephone. A consecutive sample 1594 veterans, aged 18 years or older, who scheduled visit recruited. Data analysis performed March 2019 August 2020.In 1, battery questionnaires. In 2, research assistant administered PC-PTSD-5 participants, then clinician assessor blind results structured interview PTSD.The range cut points overall gender assessed, performance evaluated by calculating weighted κ values.In total, 495 veterans (31%) participated, 396 all measures included analyses. demographically similar population (mean [SD] age, 61.4 [15.5] years; age range, 21-93 years) predominantly male (333 [84.1%]) White (296 394 [75.1%]). The had high levels (area under receiver operating characteristic curve [AUC], 0.927; 95% CI, 0.896-0.959), men (AUC, 0.932; 0.894-0.969), women 0.899, 0.824-0.974). point 4 ideally balanced false negatives positives men. However, women, this resulted numbers (6 [33.3%]). 3 fit better despite increasing number positives. rated as highly acceptable.The an tool settings. Because parameters will change according sample, clinicians should consider characteristics purposes when selecting point.

Язык: Английский

Процитировано

103
The relationship between sense of coherence and post-traumatic stress: a meta-analysis DOI Creative Commons
Sarah K. Schäfer, Nicolas Becker, Lydia King

и другие.

European journal of psychotraumatology, Год журнала: 2019, Номер 10(1)

Опубликована: Янв. 17, 2019

Background: Antonovsky's concept of sense coherence (SOC) – as a global orientation reflecting an individual's feeling confidence in both the predictability their internal and external environment ability to cope with stressful challenging situations life shows negative association symptoms post-traumatic stress. However, single studies varying study characteristics provide heterogeneous effect size estimations.Objective: The purpose current is investigate relationship between SOC stress disorder (PTSD) symptom severity for first time on meta-analytical level.Method: random-effects meta-analysis based zero-order correlations (r) consists 47 independent samples out 45 (N = 10,883).Results: After correcting sampling error, mean correlation PTSD was M(r) −.41 (excluding four outliers: −.39). this could not be generalized all types owing substantial remaining heterogeneity. Subsequent moderator analyses investigating influence different measures, trauma type duration, age gender imbalances per sample did reveal significant moderating effects.Conclusions: reveals severity: higher levels are associated lower severity. Thus, future research should progress question whether causal, by which factors it moderated.Abbreviations: CD, Cook's distance; DSM, Diagnostic Statistical Manual Mental Disorders; (G)RR, general (and specific) resistance resources; IES(-R), Impact Event Scale (Revised); PDS, Posttraumatic Stress Scale; PRISMA, Preferred Reporting Items Systematic Reviews Meta-Analyses; PTSD, disorder; SDR, standard deleted residual; SOC, coherence; SOC-R, Sense Coherence Revised

Язык: Английский

Процитировано

120
Influence of comorbid alcohol use disorders on the clinical patterns of major depressive disorder: A general population-based study DOI
Louise Carton, Baptiste Pignon,

A. Baguet

и другие.

Drug and Alcohol Dependence, Год журнала: 2018, Номер 187, С. 40 - 47

Опубликована: Март 23, 2018

Язык: Английский

Процитировано

92
Treatment of military-related post-traumatic stress disorder: challenges, innovations, and the way forward DOI
David Forbes, David Pedlar, Amy B. Adler

и другие.

International Review of Psychiatry, Год журнала: 2019, Номер 31(1), С. 95 - 110

Опубликована: Янв. 2, 2019

Post-traumatic stress disorder (PTSD) is one of the common mental disorders in military and veteran populations. Considerable research clinical opinion has been focused on understanding relationship between PTSD service implications for prevention, treatment, management. This paper examines factors associated with development this population, considers issues relating to engagement discusses empirical support best practice evidence-based treatment. The goes explore challenges those areas, particular reference treatment barriers care, as well non-response. final section addresses innovative solutions these through improvements agreed terminology definitions, strategies increase engagement, early identification approaches, predictors outcome, innovations Treatment include enhancing existing treatments, emerging non-trauma-focused interventions, novel pharmacotherapy, personalized medicine advancing functional outcomes, family intervention support, attention physical health.

Язык: Английский

Процитировано

76
A Scoping Review on the Prevalence and Determinants of Post-Traumatic Stress Disorder among Military Personnel and Firefighters: Implications for Public Policy and Practice DOI Open Access
Gloria Obuobi-Donkor, Folajinmi Oluwasina, Nnamdi Nkire

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(3), С. 1565 - 1565

Опубликована: Янв. 29, 2022

Firefighters and military personnel are public safety who protect the of individuals their properties. They usually exposed to traumatic events leaving them at risk developing mental health conditions such as post-traumatic stress disorder (PTSD). Increasing concern is being raised regarding impacts, specifically PTSD, among firefighters.

Язык: Английский

Процитировано

61
Co-occurring Chronic Pain and PTSD Among US Military Veterans: Prevalence, Correlates, and Functioning DOI
David E. Reed, Ian C. Fischer, Rhonda M. Williams

и другие.

Journal of General Internal Medicine, Год журнала: 2024, Номер 39(11), С. 2009 - 2016

Опубликована: Май 23, 2024

Язык: Английский

Процитировано

8
Home‐based delivery of variable length prolonged exposure therapy: A comparison of clinical efficacy between service modalities DOI Open Access
Leslie A. Morland, Margaret‐Anne Mackintosh, Lisa H. Glassman

и другие.

Depression and Anxiety, Год журнала: 2019, Номер 37(4), С. 346 - 355

Опубликована: Дек. 24, 2019

Objective This study examined clinical and retention outcomes following variable length prolonged exposure (PE) for posttraumatic stress disorder (PTSD) delivered by one of three treatment modalities (i.e., home-based telehealth [HBT], office-based [OBT], or in-home-in-person [IHIP]). Method A randomized trial design was used to compare variable-length PE through HBT, OBT, IHIP. Treatment duration number sessions) determined either achievement a criterion score on the PTSD Checklist Diagnostic Statistical Manual-5 (DSM-5; DSM-5) two consecutive sessions completion 15 sessions. Participants received via HBT (n = 58), OBT 59) IHIP 58). Data were collected between 2012 2018, diagnosed using Clinician-Administered Scale DSM-5 (CAPS-5), administered at baseline, posttreatment, 6 months completion. The primary outcome CAPS-5 severity. Secondary included self-reported depression symptoms, as well dropout. Results effectiveness did not differ modality across any time point; however, there significant difference in Veterans (odds ratio [OR] 2.67; 95% confidence interval [CI] 1.10, 6.52; p .031) (OR 5.08; CI 2.10; 12.26; < .001) conditions significantly more likely than veterans drop out treatment. Conclusions Providers can effectively deliver in-home, in-person although rate higher care.

Язык: Английский

Процитировано

73