Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects

Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 143, С. 112175 - 112175

Опубликована: Сен. 27, 2021

Withania somnifera (L.) Dunal (Solanaceae) has been used as a traditional Rasayana herb for long time. Traditional uses of this plant indicate its ameliorative properties against plethora human medical conditions, viz. hypertension, stress, diabetes, asthma, cancer etc. This review presents comprehensive summary the geographical distribution, use, phytochemistry, and pharmacological activities W. active constituents. In addition, it detailed account presence an constituent in many commercial preparations with curative health benefits. Clinical studies toxicological considerations extracts constituents are also elucidated. Comparative analysis relevant in-vitro, in-vivo, clinical investigations indicated potent bioactivity phytochemicals anti-cancer, anti-inflammatory, apoptotic, immunomodulatory, antimicrobial, anti-diabetic, hepatoprotective, hypoglycaemic, hypolipidemic, cardio-protective spermatogenic agents. was found to be especially neurological psychological conditions like Parkinson's disease, Alzheimer's Huntington's ischemic stroke, sleep deprivation, amyotrophic lateral sclerosis, attention deficit hyperactivity disorder, bipolar anxiety, depression, schizophrenia obsessive-compulsive disorder. The probable mechanism action that imparts potential explored. However, in-depth needed on use diseases. Besides, is performed safe efficacious preclinical health-promoting herb.

Язык: Английский

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Ethnodermatological use of medicinal plants in India: From ayurvedic formulations to clinical perspectives – A review

Journal of Ethnopharmacology, Год журнала: 2021, Номер 284, С. 114744 - 114744

Опубликована: Окт. 15, 2021

Traditional knowledge is a particular form of practice or skill set that was developed in ancient times and sustained through generations via the passing knowledge, essentially confined within specific tribe, local people, family lineages. Ethnodermatological use medicinal plants India still subject to conduct more studies see if there chemical, microbiological, and/or clinical evidence, from scientific perspective, their effectiveness for those skin disorders. Thus, this review can be basis further may provide targets drug development. We compile emphasize most important part ethnodermatology, namely, traditional applications several diseases India. also include brief explanation on dermatology Ayurvedic Unani medicine. pharmacological activity extracts derived some cited against problem as well. Different kinds key phrases such "Indian ethnodermatology", "ethnodermatology", "ethnobotany", "skin diseases", "Ayurveda dermatology", "pharmacological activity" were searched online search servers/databases Google Scholar (https://scholar.google.com/), ResearchGate (https://www.researchgate.net/), PubMed (https://pubmed.ncbi.nlm.nih.gov/), NISCAIR Online Periodicals Repository (NOPR) (http://nopr.niscair.res.in/). Based upon analyses data obtained 178 articles, we formulated findings which are summary shown Tables. A total 119 records plants' uses have been found across 39 diseases. These depicted with localities report, parts used, preparation administration methods The utilisation herbal medicine Indian subcontinent has great potential treat different human plant species used topical few only administrated orally. investigated mice, bacterial fungal pathogens, cells. Complementary therapy dermatological problems treatment remains main option millions people subcontinent. This practices ethnobotanical confirms belief analysis will accelerate discovery new, effective therapeutic agents However, evidence required determine identified contribute condition treatment, particularly atopic eczema. Today, ethnodermatology well-accepted international discipline many new initiated numerous countries. hope article development area identify generation natural treatments help meet growing consumer demand safe, sustainable, treatments. In context, research utilised elsewhere should intensified.

Язык: Английский

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Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Journal of Cellular and Molecular Medicine, Год журнала: 2022, Номер 26(11), С. 3083 - 3119

Опубликована: Май 2, 2022

Piper betle L. (synonym: betel Blanco), or vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as green gold. The plant can be found all over world is cultivatedprimarily in South East Asian countries for its beautiful glossy heart-shaped leaves, which are chewed consumed betelquidand widely used Chinese Indian folk medicine, carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also religious purposes. Hydroxychavicol most bioactive compound among wide range of phytoconstituents essential oil extracts. pharmacological attributes P. antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal many more. Immense attention has been paid nanoformulations their applications. application did not show cytotoxicity preclinical experiments, suggesting that it could serve a promising therapeutic candidate different diseases. present review comprehensively summarizes botanical description, geographical distribution, economic value cultivation, ethnobotanical uses, properties with insights toxicological, clinical efficacy, safety betle. findings suggest represents orally active safe natural agent exhibits great potential managing various human medical conditions. However, further research needed elucidate underlying molecular mechanisms action, aspects, structure-activity relationships, bioavailability synergistic interactions other drugs.

Язык: Английский

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The Role of Diet as a Modulator of the Inflammatory Process in the Neurological Diseases

Nutrients, Год журнала: 2023, Номер 15(6), С. 1436 - 1436

Опубликована: Март 16, 2023

Neurological diseases are recognized as major causes of disability and mortality worldwide. Due to the dynamic progress such Alzheimer’s disease (AD), Parkinson’s Disease (PD), Schizophrenia, Depression, Multiple Sclerosis (MD), scientists mobilized look for new more effective methods interventions. A growing body evidence suggests that inflammatory processes an imbalance in composition function gut microbiome, which play a critical role pathogenesis various neurological dietary interventions, Mediterranean diet DASH diet, or ketogenic can have beneficial effects on their course. The aim this review was take closer at its ingredients modulating inflammation associated with development and/or progression central nervous system diseases. Presented data shows consuming abundant fruits, vegetables, nuts, herbs, spices, legumes sources anti-inflammatory elements omega-3 fatty acids, polyphenols, vitamins, essential minerals, probiotics while avoiding foods promote inflammation, create positive brain environment is reduced risk Personalized nutritional interventions may constitute non-invasive strategy combating disorders.

Язык: Английский

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Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 140, С. 104795 - 104795

Опубликована: Июль 23, 2022

Язык: Английский

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Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15‐lipoxygenase

Phytotherapy Research, Год журнала: 2023, Номер 37(10), С. 4587 - 4606

Опубликована: Июнь 24, 2023

Abstract Ferroptosis, an iron‐dependent cell death characterized by lethal lipid peroxidation, is involved in chronic obstructive pulmonary disease (COPD) pathogenesis. Therefore, ferroptosis inhibition represents attractive strategy for COPD therapy. Herein, we identified natural flavonoid scutellarein as a potent inhibitor the first time, and its underlying mechanisms of COPD. In vitro, anti‐ferroptotic activity was investigated through CCK8, real‐time quantitative polymerase chain reaction (RT‐qPCR), Western blotting, flow cytometry, transmission electron microscope (TEM). vivo, induced lipopolysaccharide (LPS)/cigarette smoke (CS) assessed changes histopathological, inflammatory, ferroptotic markers. The were RNA‐sequencing (RNA‐seq), electrospray ionization mass spectra (ESI‐MS), local surface plasmon resonance (LSPR), drug affinity responsive target stability (DARTS), cellular thermal shift assay (CETSA), molecular dynamics. Our results showed that significantly inhibited Ras‐selective small molecule (RSL)‐3‐induced mitochondria injury BEAS‐2B cells, ameliorated LPS/CS‐induced mice. Furthermore, also repressed RSL‐3‐ or GPX4 down‐regulation, overactivation Nrf2/HO‐1 JNK/p38 pathways. Mechanistically, Fe 2+ elevation directly chelating . Moreover, bound to peroxidizing enzyme arachidonate 15‐lipoxygenase (ALOX15), which resulted unstable state catalysis‐related cluster. Additionally, ALOX15 overexpression partially abolished scutellarein‐mediated activity. findings revealed alleviated inhibiting via interacting with ALOX15, highlighted candidate treatment other ferroptosis‐related diseases.

Язык: Английский

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Turmeric (Curcuma longa): an insight into its food applications, phytochemistry and pharmacological properties

Vegetos, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Язык: Английский

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Dioscin: A review on pharmacological properties and therapeutic values

BioFactors, Год журнала: 2021, Номер 48(1), С. 22 - 55

Опубликована: Дек. 16, 2021

Abstract Dioscin has gained immense popularity as a natural, bioactive steroid saponin, which offers numerous medical benefits. The growing global incidence of disease‐associated morbidity and mortality continues to compromise human health, facilitating an increasingly urgent need for nontoxic, noninvasive, efficient treatment alternatives. Natural compounds can contribute vastly this field. Over recent years, studies have demonstrated the remarkable protective actions dioscin against variety malignancies, metabolic disorders, organ injuries, viral/fungal infections. successful usage phytocompound been widely seen in procedures under traditional Chinese medicine, it is becoming progressively prevalent worldwide. This review provides insight into wide spectrum pharmacological activities dioscin, reported compiled literature. various novel approaches applications also verify advantages exhibited by plant extracts commercially available drugs, highlighting potential phytochemical agents like be further incorporated clinical practice.

Язык: Английский

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Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective

Current Hypertension Reports, Год журнала: 2022, Номер 24(12), С. 687 - 692

Опубликована: Ноя. 7, 2022

Язык: Английский

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Drug Development Strategies for Malaria: With the Hope for New Antimalarial Drug Discovery—An Update

Advances in Medicine, Год журнала: 2023, Номер 2023, С. 1 - 10

Опубликована: Март 14, 2023

Malaria continued to be a deadly situation for the people of tropical and subtropical countries. Although there has been marked reduction in new cases as well mortality morbidity rates last two decades, reporting malaria caused 247 million 619000 deaths worldwide 2021, according WHO (2022). The development drug resistance declining efficacy against most antimalarial drugs/combination current clinical practice is big challenge scientific community, absence an effective vaccine, problem becomes worse. Experts from various research organizations are continuously working hard stop this disaster by employing several strategies drugs/combinations. review focuses on history discovery advantages, loopholes, opportunities associated with common being followed development.

Язык: Английский

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