Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 747 - 747

Опубликована: Янв. 6, 2024

Resveratrol has long been proposed as being beneficial to human health across multiple morbidities, yet there is currently no conclusive clinical evidence advocate its recommendation in any healthcare setting. A large cohort with high-quality data and clearly defined biomarkers or endpoints are required draw meaningful conclusions. This systematic review compiles every trial conducted using a dose of resveratrol purified form morbidities highlight the current ‘state-of-play’ knowledge gaps, informing future designs facilitate realisation resveratrol’s potential benefits health. Over last 20 years, have almost 200 studies evaluating at least 24 indications, including cancer, menopause symptoms, diabetes, metabolic syndrome, cardiovascular disease. There consensus treatment regimens for given condition endpoint, beyond fact that generally well-tolerated up 1 g/day. Additionally, consistently reduces inflammatory markers improves aspects dysregulated metabolism. In conclusion, over increasing weight suggests can benefit health, but more large, trials transition this intriguing compound from food shops clinic.

Язык: Английский

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Human Sirtuin Regulators: The “Success” Stories

Frontiers in Physiology, Год журнала: 2021, Номер 12

Опубликована: Окт. 21, 2021

The human sirtuins are a group of NAD + -dependent protein deacylases. They “erase” acyl modifications from lysine residues in various cellular targets including histones, transcription factors, and metabolic enzymes. Through these far-reaching activities, regulate diverse array biological processes ranging gene to energy metabolism. Human have been intensely pursued by both academia industry as therapeutic for broad spectrum diseases such cancer, neurodegenerative diseases, disorders. last two decades witnessed flood small molecule sirtuin regulators. However, there remain relatively few compounds targeting clinical development. This reflects the inherent issues concerning development isoform-selective potent molecules with good drug-like properties. In this article, regulators that advanced into trials will be discussed details “successful” examples future drug Special attention is given discovery compounds, mechanism action, pharmacokinetics analysis, formulation, well outcomes observed trials.

Язык: Английский

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The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(4), С. 2056 - 2056

Опубликована: Фев. 12, 2022

Obesity is a risk factor that leads to the development of other diseases such as dyslipidemia and diabetes. These three metabolic disorders can occur simultaneously, hence, treatment requires many drugs. Antioxidant compounds have been reported activities against obesity, diabetes via several mechanisms. This review aims discuss antioxidant activity together with their molecular signaling mechanism. The literature discussed in this was obtained from PUBMED database. Based on collection obtained, having (obesity, diabetes) were identified. supported by various pathways are influenced these compounds, further study which would be useful predicting drug targets for more optimal effect. provides insights utilizing one opposed It hoped future, number drugs treating altogether minimized consequently reducing side effects.

Язык: Английский

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The Role of Resveratrol Administration in Human Obesity

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(9), С. 4362 - 4362

Опубликована: Апрель 22, 2021

Obesity is a widespread disease that associated with numerous and serious comorbidities. These include metabolic syndrome, diabetes mellitus, cardiovascular-cerebrovascular disease, hypertension, obstructive sleep apnea cancer, sexual hormonal disorders. The treatment of obesity has therefore become goal great clinical social relevance. Among the therapeutic strategies against obesity, resveratrol aroused interest. This polyphenol anticancer antioxidant properties cytoprotective anti-inflammatory effects. Other favorable effects attributed to are anti-lipid, anti-aging, anti-bacterial, anti-viral, neuroprotective actions. Administration appears improve profile in obese and/or insulin-resistant patients. article aims review main results studies evaluating administering alone overweight/obese

Язык: Английский

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Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Cancers, Год журнала: 2021, Номер 13(10), С. 2317 - 2317

Опубликована: Май 12, 2021

Glioblastoma (GBM) is an aggressive, often fatal astrocyte-derived tumor of the central nervous system. Conventional medical and surgical interventions have greatly improved survival rates; however, heterogeneity, invasiveness, chemotherapeutic resistance continue to pose clinical challenges. As such, dietary natural substances—an integral component lifestyle medicine approach chronic diseases—are examined as potential agents. These heterogenous substances exert anti-GBM effects by upregulating apoptosis autophagy, inducing cell cycle arrest, interfering with metabolism, inhibiting proliferation, neuroinflammation, chemoresistance, angiogenesis, metastasis. Although these beneficial are promising, substances’ efficacy in GBM constrained their bioavailability blood–brain barrier permeability; various chemical formulations proposed improve pharmacological properties. Many reviewed available over-the-counter supplements, underscoring viability interventions. However, trials remain necessary substantiate vitro vivo properties substances.

Язык: Английский

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A Review on Rhubarb-Derived Substances as Modulators of Cardiovascular Risk Factors—A Special Emphasis on Anti-Obesity Action

Nutrients, Год журнала: 2022, Номер 14(10), С. 2053 - 2053

Опубликована: Май 13, 2022

The currently available anti-obesity therapies encounter many associated risks and side effects often causing the ineffectiveness of treatment. Therefore, various plant-derived substances have been extensively studied as a promising support or even an alternative for existing therapies. This review is dealing with potential edible ethnomedicinal rhubarb species emerging possible role rhubarb-derived extracts individual compounds in prevention obesity perspectives their use A special emphasis put on most popular specimens, i.e., Rheum rhabarbarum L. (garden rhubarb) rhaponticum (rhapontic rhubarb, Siberian rhubarb); however, other (e.g., R. officinale, palmatum, emodi) presented well. significance low-molecular specialized metabolites diversified chemical background, e.g., anthraquinones stilbenes, modulators human metabolism highlighted, including context cardiovascular disease prevention. reports present multiple encouraging properties starting from anti-lipidemic action fibre its purgative medicines, through actions compounds: inhibition enzymes cholesterol lipid metabolism, targeting key molecular regulators adipogenesis, cell energy ability to inhibit pro-inflammatory signalling pathways regulate glucose homeostasis contributing overall vivo clinical effects.

Язык: Английский

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Resveratrol in disease prevention and health promotion: A role of the gut microbiome

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер 64(17), С. 5878 - 5895

Опубликована: Янв. 2, 2023

Resveratrol is a bioactive polyphenolic compound mainly present in grapes and red wine. It known to exert beneficial effects various experimental settings, such as antioxidant, anti-inflammatory, anti-proliferative, immunoregulatory. Accumulating evidence suggests these health benefits might be, at least partially, attributed resveratrol's role protecting the intestinal barrier, regulating gut microbiome, inhibiting inflammation. The purpose of this review examine bioactivities resveratrol disease prevention promotion from standpoint microbiome. article aims provide additional insight into potential applications food nutraceutical industry.

Язык: Английский

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Effects of resveratrol supplementation on cardiac remodeling in hypertensive patients: a randomized controlled clinical trial

Hypertension Research, Год журнала: 2023, Номер 46(6), С. 1493 - 1503

Опубликована: Фев. 28, 2023

Язык: Английский

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Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review

Frontiers in Physiology, Год журнала: 2022, Номер 13

Опубликована: Март 31, 2022

Background Lipids are ubiquitous metabolites with diverse functions. Excessive lipid accumulation can trigger redistribution among metabolic organs such as adipose, liver and muscle, thus altering the metabolism. It has been revealed that disturbed metabolism would cause multiple disease complications is highly correlated human morbidity. Resveratrol (RSV), a phytoestrogen antioxidant, modulate insulin resistance profile. Recently, research on RSV supplementation to improve glucose controversial. A meta-analysis may provide scientific reference for relationship between supplementation. Methods Analysis We searched PubMed, Cochrane Library, Web of Science, Embase databases from inception October 2021 using relevant keywords. comprehensive search randomized controlled trials (RCTs) was performed. For calculating pooled effects, continuous data were by mean difference (MD) 95% confidence interval (CI). Adopting method inverse-variance random-effect, all related statistical analyses performed Rev Man V.5.3 STATA V.15 software. Results total 25 articles incorporated into final after removal duplicates checking titles abstracts excluding non-relevant articles. The selected had 1,171 participants, including 578 in placebo group 593 intervention group. According current meta-analysis, which demonstrated there significant decrease waist circumference (SMD = –0.36; CI: –0.59, –0.14; P 0.002; I 2 88%), hemoglobin A1c (–0.48; –0.69, –0.27; ≤ 0.001; 94%), cholesterol (–0.15; –0.3, –0.01; 0.003; low density lipoprotein (–0.42; –0.57, 92%), high (0.16; –0.31, –0.02; 0.03; 81%) following resveratrol administration. Conclusion These results suggest dramatic impact regulating metabolism, major clinical value intake obese diabetic patients. hope this study could more options clinicians RSV. Furthermore, future, large-scale well-designed will be warranted confirm these results. Systematic Review Registration Website [ https://www.crd.york.ac.uk/prospero/#recordDetails ], identifier [CRD42021244904].

Язык: Английский

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Pharmacological Therapy Determines the Gut Microbiota Modulation by a Pomegranate Extract Nutraceutical in Metabolic Syndrome: A Randomized Clinical Trial

Molecular Nutrition & Food Research, Год журнала: 2021, Номер 65(6)

Опубликована: Янв. 18, 2021

Scope Poly‐pharmacological therapy shapes the gut microbiota (GM) in metabolic syndrome (MetS) patients. The effects of polyphenols poly‐medicated MetS patients are unknown. Methods and results A randomized, placebo‐controlled, double‐blinded, crossover trial ( n =50) explored whether a pomegranate extract nutraceutical (PE, 320 mg phenolics/day for 1 month) affected by drug therapy. Considering lipid‐lowering (LL‐), anti‐hypertensive (HP‐) and(or) anti‐diabetic (AD‐) treatments: GM (16S rRNA sequencing), short‐chain fatty acids, 40 inflammatory‐metabolic endotoxemia‐related biomarkers, associations between biomarkers with 53 cardiometabolic dysfunctions‐related single‐nucleotide polymorphisms (SNPs), urolithin metabotypes (UMs) influence evaluated. Representative SNPs‐GM after PE include Lactococcus ClostridiumXIVa rs5443‐ GNB3 (G‐protein‐β‐polypeptide‐3) rs7903146 ‐TCF7L2 (transcription‐factor‐7‐like‐2) rs1137101‐ LEPR (leptin‐receptor). decreases sICAM‐1 LL‐patients lipopolysaccharide‐binding protein all does not affect other patients’ markers as group or stratifying UMs. After PE, increases AD‐, LL‐, HP‐patients, Bifidobacterium LL‐ while Clostridium XIVa non‐LL‐ non‐HP‐patients. Conclusion prebiotic effect depends on medication, mainly HP‐treatments. Targeting can complement therapy, but should be considered individually.

Язык: Английский

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