SIRT1, resveratrol and aging

Frontiers in Genetics, Год журнала: 2024, Номер 15

Опубликована: Май 9, 2024

Aging is linked to a time-associated decline in both cellular function and repair capacity leading malfunction on an organismal level, increased frailty, higher incidence of diseases, death. As the population grows older, there need reveal mechanisms associated with aging that could spearhead treatments postpone onset age-associated decline, extend healthspan lifespan. One possibility targeting sirtuin SIRT1, founding member family, highly conserved family histone deacetylases have been metabolism, stress response, protein synthesis, genomic instability, neurodegeneration, DNA damage repair, inflammation. Importantly, sirtuins also implicated promote health lifespan extension, while their dysregulation has cancer, neurological processes, heart disorders. SIRT1 one seven members family; each requiring nicotinamide adenine dinucleotide (NAD + ) as co-substrate for catalytic activity. Overexpression yeast, worm, fly, mice homologs animal, respectively. Moreover, extension due calorie restriction are These findings led search mimetic, which revealed compound resveratrol; (3, 5, 4′-trihydroxy-trans-stilbene) belonging stilbenoids group polyphenols. Following this finding, resveratrol other sirtuin-activating compounds extensively studied ability affect variety species, including humans via clinical studies.

Язык: Английский

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Food-Derived Micronutrients as Alleviators of Age-Related Dysfunction: A Dive into Their Effects and Cellular Mechanisms

Indian Journal of Clinical Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Язык: Английский

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Resveratrol—A Promising Therapeutic Agent with Problematic Properties

Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 134 - 134

Опубликована: Янв. 19, 2025

Resveratrol is a natural polyphenol (stilbenoid), which can be found in grape skin, red wine, blueberries, peanuts and others. The biological properties of resveratrol, particular antioxidant, anti-inflammatory, anticancer, estrogenic, vasorelaxant cardioprotective activity, are the main reason for its importance medicine pharmacy. Despite all advantages, however, there many problems related to this polyphenolic substance, such as low stability, water insolubility, poor bioavailability fast metabolism. For reason, scientists currently searching different approaches dealing with these problematic improving therapeutic usage resveratrol. This review summarizes mechanisms effects determined vitro vivo, limitations drug. article emphasizes new improvement resveratrol delivery, nanoencapsulation, formation nanocrystals, prodrugs structure analogues.

Язык: Английский

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Dietary Phenolic Compounds—Wellbeing and Perspective Applications

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4769 - 4769

Опубликована: Апрель 27, 2024

Contemporary living is continuously leading to poor everyday choices resulting in the manifestation of various diseases. The benefits plant-based nutrition are undeniable and research on topic rising. Modern man now aware possibilities that plant can provide seeking ways benefit from it. Dietary phenolic compounds among easily accessible beneficial substances exhibit antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, antifungal, antiparasitic, analgesic, anti-diabetic, anti-atherogenic, antiproliferative, as well cardio-and neuroprotective activities. Several industries exploring incorporate biologically active their produce. This review concentrated presenting current information about dietary contribution maintaining good health. Additionally, this content will demonstrate importance prosperity natural for fields, i.e., food industry, cosmetology, biotechnology, others.

Язык: Английский

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Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 13, 2025

Resveratrol, a polyphenolic compound known for its diverse biological activities, has demonstrated multiple pharmacological effects, including anti-inflammatory, anti-aging, anti-diabetic, anti-cancer, and cardiovascular protective properties. Recent studies suggest that these effects are partly mediated through the regulation of macrophage polarization, wherein macrophages differentiate into pro-inflammatory M1 or anti-inflammatory M2 phenotypes. Our review highlights how resveratrol modulates polarization various signaling pathways to achieve therapeutic effects. For example, can activate senescence-associated secretory phenotype (SASP) pathway inhibit signal transducer activator transcription (STAT3) sphingosine-1-phosphate (S1P)-YAP axes, promoting suppressing thereby inhibiting tumor growth. Conversely, it promote suppress by NF-κB activating PI3K/Akt AMP-activated protein kinase (AMPK) pathways, thus alleviating inflammatory responses. Notably, effect on is concentration-dependent; moderate concentrations tend while higher may favor polarization. This concentration dependence offers new perspectives clinical treatment but also underscores necessity precise dosage control when using resveratrol. In summary, exhibits significant potential in regulating treating related diseases.

Язык: Английский

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Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

Age-related diseases have emerged as a global concern the population ages. Consequently, understanding underlying causes of aging and exploring potential anti-aging interventions is imperative. In females, ovaries serve principal organs responsible for ovulation production female hormones. The are related to infertility, menopause, associated menopausal syndromes, with menopause representing culmination ovarian aging. Current evidence indicates that may contribute dysfunction across multiple organ systems, including, but not limited to, cognitive impairment, osteoporosis, cardiovascular disease. Nevertheless, due widespread distribution sex hormone receptors throughout body, affects only these specific also influences broader spectrum age-related in women. Despite this, impact on overall has been largely neglected. This review provides thorough summary diseases, encompassing nervous, circulatory, locomotor, urinary, digestive, respiratory, endocrine systems. Additionally, we outlined prospective therapeutic approaches addressing both aim mitigating their impacts preserving women's fertility, physical health, psychological well-being.

Язык: Английский

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Maternal Resveratrol Supplementation Attenuates Prenatal Stress Impacts on Anxiety- and Depressive-like Behaviors by Regulating Bdnf Transcripts Expression in the Brains of Adult Male Offspring Rats

Brain Sciences, Год журнала: 2025, Номер 15(2), С. 210 - 210

Опубликована: Фев. 19, 2025

Prenatal stress has been reported to harm the physiological and biochemical functions of brain offspring, potentially resulting in anxiety- depression-like behaviors later life. Trans-Resveratrol (RESV) is known for its anti-inflammatory, anxiolytic, antidepressant properties. However, whether administering RESV during pregnancy can counteract induced by maternal unknown. This study aimed assess protective potential against molecular behavioral changes prenatal stress. During pregnancy, dams received 50 mg/kg BW/day orally. They underwent a movement restriction forty-five minutes, three times day, addition being exposed artificial light 24 h before delivery. The male offspring were left undisturbed until early adulthood, at which point they assessments, including open field test, elevated plus maze, forced swim test. Subsequently, euthanized, hippocampus prefrontal cortex extracted RT-qPCR analysis measure Bdnf mRNA expression. By weaning, results showed that led reduced weight gain and, increased these effects attenuated supplementation. findings suggest prevent modulating

Язык: Английский

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Certainty and uncertainty in the biological activities of resveratrol

Food Frontiers, Год журнала: 2024, Номер 5(3), С. 849 - 854

Опубликована: Март 26, 2024

Abstract Resveratrol is a nonflavonoid polyphenolic compound with chemical structure consisting of two aromatic rings linked by methylene bridge. It exists in primary isomers and has broad range desirable biological activities, including antioxidant, anti‐inflammatory, antidiabetic, cardioprotective, antitumor activities. Some antioxidant properties resveratrol are known certainty, such as its potential to positively impact cardiovascular health, inflammation, the metabolism. On other hand, many uncertainties controversies plague efficacy, issues related bioavailability, dosing, human clinical trial results, interactions food components drugs, individual variability. In brief, although promising results have been observed vitro vivo studies, translation these findings health remains uncertain. Many trials on ongoing or proven inconclusive, making it challenging definitively determine efficacy for specific conditions dose duration treatment. may interact medications varying effects individuals. conclusion, essential approach balanced perspective, consulting healthcare professionals, considering evolving scientific evidence when decisions regarding use.

Язык: Английский

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Dietary Polyphenols and Gut Microbiota Cross-Talk: Molecular and Therapeutic Perspectives for Cardiometabolic Disease: A Narrative Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 9118 - 9118

Опубликована: Авг. 22, 2024

The intricate interplay between the gut microbiota and polyphenols has emerged as a captivating frontier in understanding potentially harnessing therapeutic potential of these bioactive compounds. Phenolic compounds, renowned for their antioxidant, anti-inflammatory, antidiabetic, anticancer properties, are subject to transformations within milieu, where diverse microbial ecosystem exerts profound effects on metabolism bioavailability. Conversely, exhibit remarkable capacity modulate composition activity microbiota, fostering bidirectional relationship that extends beyond mere nutrient processing. This symbiotic interaction holds significant implications human health, particularly cardiometabolic diseases such diabetes mellitus, metabolic-dysfunction-associated steatotic liver disease, cardiovascular disease. Through comprehensive exploration molecular interactions, this narrative review elucidates reciprocal dynamics polyphenols, unveiling novel avenues intervention disorders. By unravelling cross-talk two entities, underscores multifaceted roles overall health pivotal role modulation promising strategy mitigating burden diseases.

Язык: Английский

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Multidimensional biological activities of resveratrol and its prospects and challenges in the health field

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 12, 2024

Resveratrol (RES) is a naturally occurring polyphenolic compound. Recent studies have identified multiple potential health benefits of RES, including antioxidant, anti-inflammatory, anti-obesity, anticancer, anti-diabetic, cardiovascular, and neuroprotective properties. The objective this review to summarize analyze the on biological activities RES in disease prevention treatment, as well its metabolism bioavailability. It also discusses challenges clinical application future research directions. exhibits significant treatment many diseases. direction should focus improving bioavailability, conducting more trials determine effectiveness humans, investigating mechanism action. Once these been overcome, expected become an effective intervention.

Язык: Английский

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