Integrative Roles of Functional Foods, Microbiotics, Nutrigenetics, and Nutrigenomics in Managing Type 2 Diabetes and Obesity

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 608 - 608

Published: Feb. 7, 2025

Diabetes and obesity are globally prevalent metabolic disorders posing significant public health challenges. The effective management of these conditions requires integrated personalized strategies. This study conducted a systematic literature review, identifying 335 relevant papers, with 129 core articles selected after screening for duplicates irrelevant studies. focus the is on synergistic roles functional foods, microbiotics, nutrigenomics. Functional including phytochemicals (e.g., polyphenols dietary fibers), zoochemicals essential fatty acids), bioactive compounds from macrofungi, exhibit potential in enhancing insulin sensitivity, regulating lipid metabolism, reducing inflammatory responses, improving antioxidant capacity. Additionally, critical role gut microbiota highlighted, as its interaction foods facilitates modulation pathways. Nutrigenomics, encompassing nutrigenetics genomics, reveals how genetic variations single-nucleotide polymorphisms (SNPs)) influence responses gene expression, forming feedback loop between habits, variations, microbiota, health. review integrates insights to propose comprehensive sustainable nutrition interventions, offering novel perspectives preventing managing type 2 diabetes obesity. Future clinical studies warranted validate long-term efficacy safety

Language: Английский

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Influence of gut bacteria on type 2 diabetes: Mechanisms and therapeutic strategy

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 29, 2024

The onset and progression of type 2 diabetes mellitus (T2DM) are strongly associated with imbalances in gut bacteria, making the microbiome a new potential therapeutic focus. This commentary examines recent publication World Journal Diabetes . article explores association between T2DM microbiota, focus on pathophysiological changes related to dysbiosis. It proposes innovative microbiome-targeted strategies evaluates challenges future directions such approaches. editorial summarizes key points their discussion role elaborates influence specific microbial species disease through host–microbiota metabolic axis. provides insights for research gut-microbiota-based interventions T2DM.

Language: Английский

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Urobiome of patients with diabetic kidney disease in different stages is revealed by 2bRAD-M

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 10, 2025

Knowledge of the urinary microbiome (urobiome) in diabetic kidney disease (DKD) remains limited. The most commonly used 16S rRNA sequencing technique can only provide bacterial identification at genus level. As a novel technique, 2bRAD for (2bRAD-M) be to identify low-biomass species In this study, we 2bRAD-M compare urobiome composition patients with DKD different stages healthy individuals and those type 2 diabetes mellitus (T2DM), expectation that would find discriminative correlated DKD. Healthy controls, microalbuminuria (DKD1 group) or macroalbuminuria (DKD2 group), T2DM were recruited (n = 20 each group). first-morning urine was collected testing. albumin-to-creatinine ratio (ACR) also measured samples. Serum samples detecting clinical indicators. microbial diversity based on abundance calculated. Differential bacteria groups identified. Besides, correlation between indices analyzed. Urobiome significantly reduced groups. DKD1 group, dominant genus, followed by Pseudomonas_E, whereas DKD2 Pseudomonas_E became Escherichia notably reduced. Both Bifidobacterium Streptococcus, which top genera control substantially decreased included coli Acinetobacter johnsonii, while DKD2, oleovorans, Enterococcus faecalis, Morganella morganii showed strong renal function indicators protein levels. markedly from patients. These findings valuable insights into onset progression DKD, driven changes community structure.

Language: Английский

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Organic arabic coffee husk: Antioxidant and cytoprotective properties and potential impacts on selected human intestinal bacterial populations of individuals with diabetes

Food Research International, Journal Year: 2024, Volume and Issue: 192, P. 114730 - 114730

Published: July 4, 2024

Language: Английский

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Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 3, 2024

Diphenyl diselenide (DPDS) ameliorates nephropathy in streptozotocin (STZ)-induced type 1 diabetic rats by inhibiting oxidative stress and inflammatory reactions. However, it has not been clarified whether DPDS alleviates kidney disease (DKD) is related to the inhibition of extracellular matrix (ECM) production regulation intestinal flora disorder.

Language: Английский

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Bioinformatics analysis of the diversity of gut microbiota and different microbiota on insulin resistance in diabetes mellitus patients

Heliyon, Journal Year: 2023, Volume and Issue: 9(12), P. e22117 - e22117

Published: Nov. 10, 2023

It aimed to explore the diversity of gut microbiota (GM) and effect different on insulin resistance in diabetes mellitus (DM) patients through bioinformatics analysis.Microarray data were obtained from GEO database. GM samples DM healthy controls collected, 16S rRNA gene sequencing was carried out adopting high-throughput technology. The differential expression genes screened using Qlucore Omics Explorer 3.0 software. Subsequently, online tools such as STRING DAVID utilized for analysis genes. differences bacterial between evaluated by analyzing indicators microbiota, Shannon Chao1 indexes. Differential abundance functional prediction adopted its possible metabolic pathways controls. And specific taxa analyzed.GM had significant differences. lower compared with controls, indicated a decrease showed that there multiple communities including some at genus-level. Functional also revealed potential related patients. HEXB, ZC3H12A, CCR, CXCR3, GBR10, CDK9, TXN, IGFBP3, PDHA1, NDUFB3 may be targets treatment.There are occurrence development resistance.

Language: Английский

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Diabetic Kidney Disease: Contribution of Phenyl Sulfate Derived from Dietary Tyrosine upon Gut Microbiota Catabolism

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1153 - 1153

Published: Sept. 13, 2024

Deranged gut microbiota can release increased levels of uremic toxins leading to exacerbated kidney injury. In diabetic disease (DKD), phenyl sulfate (PS) derived from tyrosine catabolism by has been demonstrated be both an early diagnostic marker and a therapeutic target. this perspective article, we summarize PS generation pathways recent findings on injury in DKD. Increasing evidence shown that the underlying mechanisms PS-induced mainly involve oxidative stress, redox imbalance, mitochondrial dysfunction, which all may targeted attenuate For future research directions, think deeper understanding pathogenic role using variety animal models should investigated. Moreover, also suggest beneficial approaches could used mitigate deleterious effect kidney. These include caloric restriction, administration ketogenic drugs, diets or natural products; conducted under obese conditions.

Language: Английский

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Huperzine A as a Potential Therapeutic Drug for Diabetic Nephropathy: Insights from Transcriptome, Metabolome, Microbiome, and Network Pharmacology Analysis

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107392 - 107392

Published: Sept. 2, 2024

Diabetic nephropathy (DN) is a major complication of diabetes mellitus (DM) without curative interventions currently. Huperzine A (Hup A), natural alkaloid, has demonstrated significant hypoglycemic and anti-inflammatory effects. We aim to investigate the protective effects Hup on DN explore underlying mechanisms METHODS: applied STZ induced diabetic rats as model leveraged combination analysis transcriptome, metabolome, microbiome, network pharmacology (NP). The total effect was detected (i.e. urine protein, renal tissue structure) differential genes were further verified at level patients, db/db mice cells. Clinical data small interfering RNA (siRNA)-Apoe adopted.

Language: Английский

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Metabolites Potentially Derived from Gut Microbiota Associated with Podocyte, Proximal Tubule, and Renal and Cerebrovascular Endothelial Damage in Early Diabetic Kidney Disease in T2DM Patients

Metabolites, Journal Year: 2023, Volume and Issue: 13(8), P. 893 - 893

Published: July 28, 2023

Complications due to type 2 diabetes mellitus (T2DM) such as diabetic kidney disease (DKD) and cerebral small vessel (CSVD) have a powerful impact on mortality morbidity. Our current diagnostic markers become outdated T2DM-related complications continue develop. The aim of the investigation was point out relationship between previously selected metabolites which are potentially derived from gut microbiota indicators endothelial, proximal tubule (PT), podocyte dysfunction, neurosonological indices. study participants were 20 healthy controls 90 T2DM patients divided into three stages: normoalbuminuria, microalbuminuria, macroalbuminuria. Serum urine determined by untargeted targeted metabolomic techniques. PT dysfunction assessed ELISA technique, indices provided an ultrasound device with high resolution (MYLAB 8-ESAOTE Italy). descriptive statistical analysis followed univariable multivariable linear regression analyses. In conclusion, in serum, arginine (sArg), butenoylcarnitine (sBCA), indoxyl sulfate (sIS) expressed biomarker potential terms renal endothelial carotid atherosclerosis, whereas sorbitol (sSorb) may be blood-brain barrier (BBB) dysfunction. urine, BCA IS associated damage, PCS correlated

Language: Английский

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Diphenyl Diselenide Protects Against Diabetic Nephropathy Through Modulating Oxidative Stress and Gut Microbiota Dysbiosis in Streptozotocin-Induced Diabetic Rats

Published: Jan. 1, 2024

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Language: Английский

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