Advancements and Challenges in Stem Cell Transplantation for Regenerative Medicine
Heliyon,
Год журнала:
2024,
Номер
10(16), С. e35836 - e35836
Опубликована: Авг. 1, 2024
Stem
cell
transplantation
has
emerged
as
a
promising
avenue
in
regenerative
medicine,
potentially
facilitating
tissue
repair
degenerative
diseases
and
injuries.
This
review
comprehensively
examines
recent
developments
challenges
stem
transplantation.
It
explores
the
identification
isolation
of
various
types,
including
embryonic,
induced
pluripotent,
adult
cells
derived
from
multiple
sources.
Additionally,
highlights
tissue-specific
applications
these
cells,
focusing
on
bone
cartilage
regeneration,
treatment
neurological
disorders,
management
hematological
conditions.
Future
advancements
effective
resolution
current
will
be
crucial
fully
realizing
potential
medicine.
With
responsible
ethical
practices,
field
can
transform
disease
injury
treatment,
ultimately
improving
quality
life
for
countless
individuals.
Язык: Английский
TCP80-1, a new levan-neoseries fructan from Tupistra chinensis Baker rhizomes alleviates ulcerative colitis induced by dextran sulfate sodium in Drosophila melanogaster model
Food Research International,
Год журнала:
2025,
Номер
203, С. 115860 - 115860
Опубликована: Янв. 31, 2025
Язык: Английский
MOLECULAR MECHANISM AND THERAPEUTIC POTENTIAL OF BERBERINE, BAICALEIN, ORIDONIN IN THE TREATMENT OF COLORECTAL CANCER – A REVIEW
Sonia Ramamoorthy,
Jegadeesh Ramasamy,
GOPINATH SAMBASIVAM
и другие.
Asian Journal of Pharmaceutical and Clinical Research,
Год журнала:
2025,
Номер
unknown, С. 31 - 43
Опубликована: Апрель 7, 2025
The
aim
of
this
research
is
to
assess
the
effect
berberine
and
baicalein
oridonin
(ORI)
treatment
on
colorectal
cancer
(CRC)
cells.
examines
how
these
compounds
bring
about
cellular
alterations,
stop
cell
cycle
progression,
trigger
death.
cancer-fighting
agents
together
with
ORI
demonstrate
strong
anticancer
properties
against
CRC
tissues
through
metabolic
instability
arrest
leading
apoptosis.
affects
activation
TP53/TCF4
mechanisms
which
creates
endoplasmic
reticulum
stress
then
leads
higher
reactive
oxygen
species
production
alongside
calcium
ion
imbalances.
retinoid
X
receptor
alpha
mechanism
performs
better
than
in
colon
growth
inhibition.
Berberine
suppresses
progression
its
ability
influence
transforming
factor-beta
signaling
pathway
inhibitory
action
epithelial-mesenchymal
transition
weakening
liver
metastasis.
altered
composition
gut
microbes
reduces
tissue
tumorigenesis
as
well
total
microbial
abundance.
shows
anti-metastatic
capabilities
by
blocking
actions
matrix
metallopeptidase
(MMP)-2
MMP-9
enzymes
play
important
roles
cells
spreading
during
suppression
occurs
berberine-mediated
G2/M
death
that
results
cyclin
B1
cdc2
cdc25c
protein
downregulation.
anti-inflammatory
agent
acts
a
major
element
developing
tumorous
lesions
associated
colitis.
compound
speeds
up
phase
role
regulating
toll-like
4/nuclear
factor-kappa
B
HT-29
regulatory
process
decrease
stems
from
inflammation
while
also
restricting
multiplication.
Язык: Английский
M64HCl, a focal adhesion kinase activator, promotes intestinal mucosal healing in rats
BMC Gastroenterology,
Год журнала:
2025,
Номер
25(1)
Опубликована: Май 8, 2025
Intestinal
mucosal
injury
may
arise
from
various
factors.
While
many
drugs
target
the
causative
factors,
none
directly
stimulate
wound
healing.
We
found
that
specific
focal
adhesion
kinase
(FAK)
activator,
M64HCl,
promotes
intestinal
healing
in
mice.
This
study
aims
to
further
validate
therapeutic
impact
of
M64HCl
on
repair
rats
as
a
second
species.
Wistar
were
assigned
one
four
groups:
normal
control,
1-day
+
vehicle,
4-day
or
M64HCl.
was
induced
by
serosally
applying
75%
acetic
acid.
Immediately
after
injury,
received
either
continuous
infusion
(25
mg/kg/day)
its
vehicle
(saline).
Four
days
post-injury,
blood
drawn
measure
levels
and
assess
liver
kidney
function.
The
intestines
removed
opened,
ulcer
areas
photographed
for
size
quantification,
tissues
fixed
histological
immunohistochemical
analysis.
substantially
reduced
area
gross
examination,
while
analysis
showed
alleviation
pathological
changes
with
treatment.
Immunohistochemical
confirmed
increased
immunoreactivity
phosphorylated
FAK
epithelium
adjacent
M64HCl-treated
rats.
However,
there
no
change
percentage
Ki67-positive
cells
each
crypt
at
edge
area.
Serum
creatinine,
ALT,
AST
did
not
differ
between
groups
without
water-soluble
acid-induced
be
useful
treating
gastrointestinal
injury.
Язык: Английский
Unraveling the cross-talk between a highly virulent PEDV strain and the host via single-cell transcriptomic analysis
Journal of Virology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
ABSTRACT
Porcine
epidemic
diarrhea
virus
(PEDV)
causes
severe
intestinal
damage
and
high
mortality
in
neonatal
piglets.
The
continuous
emergence
of
new
strains
has
brought
challenges
to
prevention
control.
In
this
study,
we
isolated
characterized
a
prevalent
PEDV
virulent
strain
analyzed
19,612
jejunal
cells
from
PEDV-infected
control
piglets
using
single-cell
sequencing,
revealing
significant
changes
cellular
composition,
gene
expression,
intercellular
communication.
response
infection,
epithelial
repair
was
enhanced
through
increased
proliferation
differentiation
stem
cells,
transit-amplifying
(TA)
progenitor
into
enterocytes.
Additionally,
disrupted
communication,
compromising
functionality
while
triggering
immune
responses,
with
IFN-γ
IL-10
signaling
activation
acting
as
critical
regulators
balance
tissue
homeostasis.
Beyond
enterocytes,
viral
genes
were
detected
various
other
cell
types.
Further
experiments
confirmed
that
could
initiate
replication
B
T
lymphocytes
but
unable
produce
infectious
progeny,
additionally
undergoing
virus-induced
apoptosis.
These
findings
provide
insights
tropism,
evasion,
repair,
complex
host-pathogen
interactions
shape
disease
progression
regeneration,
thereby
contributing
better
understanding
enteric
coronavirus
pathogenesis.
IMPORTANCE
persistent
circulation
porcine
poses
major
threat
the
swine
industry,
emerging
complicating
efforts.
Currently,
no
effective
measures
completely
prevent
transmission,
highlighting
need
understand
PEDV-host
interactions.
used
sequencing
identify
types
explore
interplay
between
host
PEDV.
essential
pathogenesis
facilitate
design
targeted
antiviral
interventions.
Язык: Английский
Intestinal epithelial cells in health and disease
Tissue Barriers,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 22, 2025
This
comprehensive
review
delves
into
the
pivotal
role
of
intestinal
epithelial
cells
in
context
various
diseases.
It
provides
an
in-depth
analysis
diverse
types
and
functions
these
cells,
explores
influence
multiple
signaling
pathways
on
their
differentiation,
elucidates
critical
roles
a
spectrum
The
significance
gastrointestinal
tract
maintaining
overall
health
is
extremely
important
cannot
be
exaggerated.
complex
elongated
organ
acts
as
crucial
link
between
internal
external
environments,
making
it
vulnerable
to
harmful
influences.
Preserving
normal
structure
function
gut
essential
for
well-being.
Intestinal
serve
primary
defense
mechanism
within
play
preventing
substances
from
infiltrating
body.
As
main
components
digestive
system,
they
not
only
participate
absorption
secretion
nutrients
maintenance
barrier
but
also
immune
defense.
Therefore,
vital
importance
health.
Язык: Английский
Nisin A elevates adenosine to achieve anti-inflammatory activity
Food & Function,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
study
uncovers
that
nisin
A
achieves
excellent
anti-inflammatory
activity
via
enhancing
the
level
of
adenosine,
followed
by
up-regulation
sphingolipid
signaling
pathway
and
down-regulation
purine
metabolism.
Язык: Английский
Understanding how the immune system environment is controlled in high myopia cases
Xin Qiao,
Wahid Shah,
Xiaoqin Gao
и другие.
International Immunopharmacology,
Год журнала:
2024,
Номер
143, С. 113138 - 113138
Опубликована: Окт. 2, 2024
Язык: Английский
The molecular determinants of phenotypic plasticity in homeostasis and neoplasia
Опубликована: Дек. 13, 2024
Phenotypic
plasticity,
the
capacity
of
cells
to
transition
between
distinct
phenotypic
and
lineage
states
over
time,
is
a
genetically
epigenetically
encoded
trait
essential
for
normal
development
adult
tissue
homeostasis.
In
cancer,
plasticity
programs
can
be
deployed
aberrantly
enable
disease
progression
acquired
therapeutic
resistance.
Cancer
current
barrier
achieving
cures
advanced
cancers
using
available
molecularly
targeted
therapies.
This
review
summarizes
complex
interconnected
molecular
pathways
implicated
in
both
context
homeostasis
cancer.
Molecular
convergent
these
contexts
are
highlighted
while
enabling
distinguished
from
those
that
specify
phenotype
already
plastic
cells.
Key
unresolved
questions
field
discussed
along
with
emerging
technologies
may
used
help
answer
them.
Язык: Английский