The molecular determinants of phenotypic plasticity in homeostasis and neoplasia DOI Creative Commons

Bradley Balk,

David W. Goodrich

Published: Dec. 13, 2024

Phenotypic plasticity, the capacity of cells to transition between distinct phenotypic and lineage states over time, is a genetically epigenetically encoded trait essential for normal development adult tissue homeostasis. In cancer, plasticity programs can be deployed aberrantly enable disease progression acquired therapeutic resistance. Cancer current barrier achieving cures advanced cancers using available molecularly targeted therapies. This review summarizes complex interconnected molecular pathways implicated in both context homeostasis cancer. Molecular convergent these contexts are highlighted while enabling distinguished from those that specify phenotype already plastic cells. Key unresolved questions field discussed along with emerging technologies may used help answer them.

Language: Английский

Advancements and Challenges in Stem Cell Transplantation for Regenerative Medicine DOI Creative Commons

Lingxi Wei,

Wenqi Yan,

Wahid Shah

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e35836 - e35836

Published: Aug. 1, 2024

Stem cell transplantation has emerged as a promising avenue in regenerative medicine, potentially facilitating tissue repair degenerative diseases and injuries. This review comprehensively examines recent developments challenges stem transplantation. It explores the identification isolation of various types, including embryonic, induced pluripotent, adult cells derived from multiple sources. Additionally, highlights tissue-specific applications these cells, focusing on bone cartilage regeneration, treatment neurological disorders, management hematological conditions. Future advancements effective resolution current will be crucial fully realizing potential medicine. With responsible ethical practices, field can transform disease injury treatment, ultimately improving quality life for countless individuals.

Language: Английский

Citations

9
TCP80-1, a new levan-neoseries fructan from Tupistra chinensis Baker rhizomes alleviates ulcerative colitis induced by dextran sulfate sodium in Drosophila melanogaster model DOI

Tanggan Wang,

Zhong‐Nan Wu,

Meifeng Li

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 203, P. 115860 - 115860

Published: Jan. 31, 2025

Language: Английский

Citations

1
MOLECULAR MECHANISM AND THERAPEUTIC POTENTIAL OF BERBERINE, BAICALEIN, ORIDONIN IN THE TREATMENT OF COLORECTAL CANCER – A REVIEW DOI Open Access

Sonia Ramamoorthy,

Jegadeesh Ramasamy,

GOPINATH SAMBASIVAM

et al.

Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2025, Volume and Issue: unknown, P. 31 - 43

Published: April 7, 2025

The aim of this research is to assess the effect berberine and baicalein oridonin (ORI) treatment on colorectal cancer (CRC) cells. examines how these compounds bring about cellular alterations, stop cell cycle progression, trigger death. cancer-fighting agents together with ORI demonstrate strong anticancer properties against CRC tissues through metabolic instability arrest leading apoptosis. affects activation TP53/TCF4 mechanisms which creates endoplasmic reticulum stress then leads higher reactive oxygen species production alongside calcium ion imbalances. retinoid X receptor alpha mechanism performs better than in colon growth inhibition. Berberine suppresses progression its ability influence transforming factor-beta signaling pathway inhibitory action epithelial-mesenchymal transition weakening liver metastasis. altered composition gut microbes reduces tissue tumorigenesis as well total microbial abundance. shows anti-metastatic capabilities by blocking actions matrix metallopeptidase (MMP)-2 MMP-9 enzymes play important roles cells spreading during suppression occurs berberine-mediated G2/M death that results cyclin B1 cdc2 cdc25c protein downregulation. anti-inflammatory agent acts a major element developing tumorous lesions associated colitis. compound speeds up phase role regulating toll-like 4/nuclear factor-kappa B HT-29 regulatory process decrease stems from inflammation while also restricting multiplication.

Language: Английский

Citations

0
M64HCl, a focal adhesion kinase activator, promotes intestinal mucosal healing in rats DOI Creative Commons
Guiming Liu, Ahmed M. Elsayed, Louis Boafo Kwantwi

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 8, 2025

Intestinal mucosal injury may arise from various factors. While many drugs target the causative factors, none directly stimulate wound healing. We found that specific focal adhesion kinase (FAK) activator, M64HCl, promotes intestinal healing in mice. This study aims to further validate therapeutic impact of M64HCl on repair rats as a second species. Wistar were assigned one four groups: normal control, 1-day + vehicle, 4-day or M64HCl. was induced by serosally applying 75% acetic acid. Immediately after injury, received either continuous infusion (25 mg/kg/day) its vehicle (saline). Four days post-injury, blood drawn measure levels and assess liver kidney function. The intestines removed opened, ulcer areas photographed for size quantification, tissues fixed histological immunohistochemical analysis. substantially reduced area gross examination, while analysis showed alleviation pathological changes with treatment. Immunohistochemical confirmed increased immunoreactivity phosphorylated FAK epithelium adjacent M64HCl-treated rats. However, there no change percentage Ki67-positive cells each crypt at edge area. Serum creatinine, ALT, AST did not differ between groups without water-soluble acid-induced be useful treating gastrointestinal injury.

Language: Английский

Citations

0
Nisin A elevates adenosine to achieve anti-inflammatory activity DOI
Yonglu Li, Yadi Wang, Shihai Yan

et al.

Food & Function, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This study uncovers that nisin A achieves excellent anti-inflammatory activity via enhancing the level of adenosine, followed by up-regulation sphingolipid signaling pathway and down-regulation purine metabolism.

Language: Английский

Citations

0
Understanding how the immune system environment is controlled in high myopia cases DOI

Xin Qiao,

Wahid Shah,

Xiaoqin Gao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113138 - 113138

Published: Oct. 2, 2024

Language: Английский

Citations

0
The molecular determinants of phenotypic plasticity in homeostasis and neoplasia DOI Creative Commons

Bradley Balk,

David W. Goodrich

Published: Dec. 13, 2024

Phenotypic plasticity, the capacity of cells to transition between distinct phenotypic and lineage states over time, is a genetically epigenetically encoded trait essential for normal development adult tissue homeostasis. In cancer, plasticity programs can be deployed aberrantly enable disease progression acquired therapeutic resistance. Cancer current barrier achieving cures advanced cancers using available molecularly targeted therapies. This review summarizes complex interconnected molecular pathways implicated in both context homeostasis cancer. Molecular convergent these contexts are highlighted while enabling distinguished from those that specify phenotype already plastic cells. Key unresolved questions field discussed along with emerging technologies may used help answer them.

Language: Английский

Citations

0