Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер 15(2), С. 1126 - 1142

Опубликована: Янв. 7, 2025

Recently, photodynamic therapy (PDT) has gained considerable attention as a promising therapeutic approach for the treatment of psoriasis. Unfortunately, activation high mobility group box 1 protein (HMGB1) by PDT triggers innate and adaptive immune responses, which exacerbate skin inflammation. Herein, we combined glycyrrhizic acid (GA), natural anti-inflammatory compound immunomodulator derived from herb Glycyrrhiza uralensis Fisch., with actuated photosensitizer chlorin e6 (Ce6) co-loading them in GA-based lipid nanoparticles coated catechol-modified quaternary chitosan salt (GC NPs/QCS-C). GC NPs/QCS-C exhibited drug loading efficacy, uniform size distribution, an ideal topical adhesive property, enhanced retention penetration psoriasis-like lesions, intracellular uptake epidermal cells compared counterparts. Subsequently, transdermal administration followed near-infrared laser radiation imiquimod-induced mouse model significantly ameliorated psoriasis symptoms, promoted apoptosis hyperproliferative cells, alleviated inflammatory cascade. The significant outcomes were attributed to synergistic effects GA on modulating cell recruitment inhibiting dendritic maturation. Our results demonstrated that bio-adhesive nanosystem combines Ce6 offers chemo-phototherapeutic strategy treatment.

Язык: Английский

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A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125385 - 125385

Опубликована: Фев. 1, 2025

Язык: Английский

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Delivery of nanocarriers with dissolvable microneedles for skin treatments: approaches and challenges

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106836 - 106836

Опубликована: Март 1, 2025

Язык: Английский

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Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Molecular Pharmaceutics, Год журнала: 2024, Номер 21(5), С. 2118 - 2147

Опубликована: Апрель 25, 2024

The various kinds of nanocarriers (NCs) have been explored for the delivery therapeutics designed management skin manifestations. NCs are considered as one promising approaches attributable to sustained release and enhanced penetration. Despite extensive applications NCs, challenges in their via barrier (majorly stratum corneum) persisted. To overcome all associated with microneedle (MN) technology has emerged a beacon hope. Programmable drug release, being painless, its minimally invasive nature make it an intriguing strategy circumvent multiple systems. integration positive traits MNs boosts therapeutic effectiveness by evading corneum, facilitating through enhancing targeted delivery. This review discusses function skin, importance MNs, types superiority NC-loaded MNs. We highlighted NC-integrated ailments, combinational delivery, active targeting, vivo imaging, theranostics. clinical trials, patent portfolio, marketed products drug/NC-integrated covered. Finally, regulatory hurdles toward benchtop-to-bedside translation, along prospects needed scale up MN technology, deliberated. current is anticipated deliver thoughtful visions researchers, clinicians, formulation scientists successful development MN-technology-based product carefully optimizing variables.

Язык: Английский

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Spiderweb‐Shaped Iron‐Coordinated Polymeric Network as the Novel Coating on Microneedles for Transdermal Drug Delivery Against Infectious Wounds

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 12, 2024

Abstract Coated microneedles (CMNs) are a minimally invasive platform for immediate‐release transdermal drug delivery. However, the practical applications of CMNs have been significantly hindered by challenges associated with complex formulations, single function, and limited loading capacity. This study has developed spiderweb‐shaped iron‐coordinated polymeric nanowire network (Fe‐IDA NWs). The resulting Fe‐IDA NWs endowed certain viscosity due to synergy multiple supramolecular interactions. allows them replace traditional thickeners as microneedle coatings. NWs‐coated MNs) display rapid disintegration in skin model, which also enables swift diffusion their payloads into deeper layers. Additionally, MNs exhibit desirable enzymatic activity potential antibacterial ability. Thus, can enhance therapeutic efficacy against wound infection through synergistic effects, avoid overly complicated formulation release nontherapeutic molecules conventional CMNs. As proof‐of‐concept, loaded chlorin e6 showed chemodynamic‐photodynamic effect methicillin‐resistant Staphylococcus aureus‐infected model mice. Collectively, this work significant implications future CMNs‐based delivery systems expands application fields metal coordination polymer (MCP) materials.

Язык: Английский

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Fabrication of Hybrid Coated Microneedles with Donepezil Utilizing Digital Light Processing and Semisolid Extrusion Printing for the Management of Alzheimer’s Disease

Molecular Pharmaceutics, Год журнала: 2024, Номер 21(9), С. 4450 - 4464

Опубликована: Авг. 20, 2024

Microneedle (MN) patches are gaining increasing attention as a cost-effective technology for delivering drugs directly into the skin. In present study, two different 3D printing processes were utilized to produce coated MNs, namely, digital light processing (DLP) and semisolid extrusion (SSE). Donepezil (DN), cholinesterase inhibitor administered treatment of Alzheimer's disease, was incorporated coating material. Physiochemical characterization MNs confirmed successful incorporation donepezil well stability suitability materials transdermal delivery. Optical microscopy SEM studies validated uniform weight distribution precise dimensions MN arrays, while mechanical testing ensured MNs' robustness, ensuring efficient skin penetration. vitro conducted evaluate produced patches, indicating their potential use in clinical treatment. Permeation revealed significant increase DN permeation compared plain material, affirming effectiveness enhancing drug Confocal laser scanning (CLSM) elucidated API, within layers, demonstrating sustained release transcellular transport pathways. Finally, cell also on NIH3T3 fibroblasts biocompatibility safety printed objects applications.

Язык: Английский

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Recent Advances in Nano and Micro formulations of Ginsenoside to Enhanced their Therapeutics Efficacy

Phytomedicine, Год журнала: 2024, Номер 134, С. 156007 - 156007

Опубликована: Авг. 30, 2024

Язык: Английский

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Targeting inflammation with hyaluronic acid-based micro- and nanotechnology: A disease-oriented review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 280, С. 135923 - 135923

Опубликована: Сен. 23, 2024

Язык: Английский

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Hyaluronic acid dissolving microneedle patch-assisted acupoint transdermal delivery of triptolide for effective rheumatoid arthritis treatment

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 24, 2024

Triptolide (TP), a major active component of the herb Tripterygium wilfordii Hook F, has been shown excellent pharmacological effects on rheumatoid arthritis. However, TP is prone to causing severe organ toxicity, which limits its clinical application. In recent years, microneedle technology provided new option for treatment arthritis due advantages efficient local transdermal drug delivery. this study, we constructed platform deliver locally joints, thereby enhancing penetration and reducing systemic toxicity. Additionally, investigated whether acupoint delivery can produce synergistic effect needles drugs. First, was loaded into microneedles using polyvinylpyrrolidone hyaluronic acid as matrix materials. Next, established rat adjuvant-induced (AIA) model evaluate therapeutic TP-loaded microneedles. The experiments showed that alleviated AIA rats' inflammatory response, joint swelling, bone erosion. there no significant difference in observed non-acupoint administration groups. conclusion, have safety, convenience, high efficacy over conventional routes, laying foundation system-based

Язык: Английский

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Augmented Transdermal Delivery of Curcumin for the Effective Management of Plaque Psoriasis – Design, Formulation, Characterisation, and In Vivo Studies

AAPS PharmSciTech, Год журнала: 2023, Номер 24(5)

Опубликована: Июнь 8, 2023

Язык: Английский

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