Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(5), P. 2118 - 2147

Published: April 25, 2024

The various kinds of nanocarriers (NCs) have been explored for the delivery therapeutics designed management skin manifestations. NCs are considered as one promising approaches attributable to sustained release and enhanced penetration. Despite extensive applications NCs, challenges in their via barrier (majorly stratum corneum) persisted. To overcome all associated with microneedle (MN) technology has emerged a beacon hope. Programmable drug release, being painless, its minimally invasive nature make it an intriguing strategy circumvent multiple systems. integration positive traits MNs boosts therapeutic effectiveness by evading corneum, facilitating through enhancing targeted delivery. This review discusses function skin, importance MNs, types superiority NC-loaded MNs. We highlighted NC-integrated ailments, combinational delivery, active targeting, vivo imaging, theranostics. clinical trials, patent portfolio, marketed products drug/NC-integrated covered. Finally, regulatory hurdles toward benchtop-to-bedside translation, along prospects needed scale up MN technology, deliberated. current is anticipated deliver thoughtful visions researchers, clinicians, formulation scientists successful development MN-technology-based product carefully optimizing variables.

Language: Английский

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Fabrication of Hybrid Coated Microneedles with Donepezil Utilizing Digital Light Processing and Semisolid Extrusion Printing for the Management of Alzheimer’s Disease

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(9), P. 4450 - 4464

Published: Aug. 20, 2024

Microneedle (MN) patches are gaining increasing attention as a cost-effective technology for delivering drugs directly into the skin. In present study, two different 3D printing processes were utilized to produce coated MNs, namely, digital light processing (DLP) and semisolid extrusion (SSE). Donepezil (DN), cholinesterase inhibitor administered treatment of Alzheimer's disease, was incorporated coating material. Physiochemical characterization MNs confirmed successful incorporation donepezil well stability suitability materials transdermal delivery. Optical microscopy SEM studies validated uniform weight distribution precise dimensions MN arrays, while mechanical testing ensured MNs' robustness, ensuring efficient skin penetration. vitro conducted evaluate produced patches, indicating their potential use in clinical treatment. Permeation revealed significant increase DN permeation compared plain material, affirming effectiveness enhancing drug Confocal laser scanning (CLSM) elucidated API, within layers, demonstrating sustained release transcellular transport pathways. Finally, cell also on NIH3T3 fibroblasts biocompatibility safety printed objects applications.

Language: Английский

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Spiderweb‐Shaped Iron‐Coordinated Polymeric Network as the Novel Coating on Microneedles for Transdermal Drug Delivery Against Infectious Wounds

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 12, 2024

Abstract Coated microneedles (CMNs) are a minimally invasive platform for immediate‐release transdermal drug delivery. However, the practical applications of CMNs have been significantly hindered by challenges associated with complex formulations, single function, and limited loading capacity. This study has developed spiderweb‐shaped iron‐coordinated polymeric nanowire network (Fe‐IDA NWs). The resulting Fe‐IDA NWs endowed certain viscosity due to synergy multiple supramolecular interactions. allows them replace traditional thickeners as microneedle coatings. NWs‐coated MNs) display rapid disintegration in skin model, which also enables swift diffusion their payloads into deeper layers. Additionally, MNs exhibit desirable enzymatic activity potential antibacterial ability. Thus, can enhance therapeutic efficacy against wound infection through synergistic effects, avoid overly complicated formulation release nontherapeutic molecules conventional CMNs. As proof‐of‐concept, loaded chlorin e6 showed chemodynamic‐photodynamic effect methicillin‐resistant Staphylococcus aureus‐infected model mice. Collectively, this work significant implications future CMNs‐based delivery systems expands application fields metal coordination polymer (MCP) materials.

Language: Английский

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Multiple strategies approach: A novel crosslinked hydrogel forming chitosan-based microneedles chemowrap patch loaded with 5-fluorouracil liposomes for chronic wound cancer treatment

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 134973 - 134973

Published: Aug. 24, 2024

Language: Английский

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Targeting inflammation with hyaluronic acid-based micro- and nanotechnology: A disease-oriented review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 135923 - 135923

Published: Sept. 23, 2024

Language: Английский

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Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: 15(2), P. 1126 - 1142

Published: Jan. 7, 2025

Recently, photodynamic therapy (PDT) has gained considerable attention as a promising therapeutic approach for the treatment of psoriasis. Unfortunately, activation high mobility group box 1 protein (HMGB1) by PDT triggers innate and adaptive immune responses, which exacerbate skin inflammation. Herein, we combined glycyrrhizic acid (GA), natural anti-inflammatory compound immunomodulator derived from herb Glycyrrhiza uralensis Fisch., with actuated photosensitizer chlorin e6 (Ce6) co-loading them in GA-based lipid nanoparticles coated catechol-modified quaternary chitosan salt (GC NPs/QCS-C). GC NPs/QCS-C exhibited drug loading efficacy, uniform size distribution, an ideal topical adhesive property, enhanced retention penetration psoriasis-like lesions, intracellular uptake epidermal cells compared counterparts. Subsequently, transdermal administration followed near-infrared laser radiation imiquimod-induced mouse model significantly ameliorated psoriasis symptoms, promoted apoptosis hyperproliferative cells, alleviated inflammatory cascade. The significant outcomes were attributed to synergistic effects GA on modulating cell recruitment inhibiting dendritic maturation. Our results demonstrated that bio-adhesive nanosystem combines Ce6 offers chemo-phototherapeutic strategy treatment.

Language: Английский

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Nanocarriers and their Integrated Microneedle Systems-Mediated Drug Delivery for the Treatment of Moderate-Severe Dermatological Diseases: Recent Progress, Applications and Future Perspectives

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106748 - 106748

Published: Feb. 22, 2025

Language: Английский

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A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125385 - 125385

Published: Feb. 1, 2025

Language: Английский

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Advances in dissolving microneedles-based drug delivery system for treating dermatological diseases

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106785 - 106785

Published: March 1, 2025

Language: Английский

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Development and comparative analysis of clobetasol-loaded microneedle patches versus clobetasol propionate ointment in experimental induced-psoriasis model

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125423 - 125423

Published: March 1, 2025

Language: Английский

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