Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 9, 2023
Abstract
The
present
study
aimed
to
develop
a
composite
material
using
sodium
alginate
and
hydroxypropyl
methylcellulose
in
combination
with
hydroxyapatite.
was
doped
zinc
developed
into
nanocomposite
by
ionic
gelation
solvent
precipitation
methods.
prepared
characterized
scanning
electron
microscopy,
atomic
force
dynamic
light
scattering,
FTIR,
XRD
studies.
In
vivo
pharmacological
studies
were
carried
out
establish
the
bone
targeting
tissue
regeneration
efficacy
of
nanocomposite.
checked
for
cell
toxicity
performing
an
MTT
assay
MG63
line
molecular
mechanism
efficiency
assessed
silico
evaluation
method.
results
confirmed
polymeric
interlinking
successful
preparation
biodegradable
excipients.
SEM
AFM
indicated
that
within
80-200
nm
size
range.
not
cytotoxic
well
tolerated
line.
validation
docking
suggested
effectively
targeted
as
had
osteogenesis
properties
following
whereby
it
could
block
Farnesyl
Diphosphate
Synthetase
mevalonate
pathway
which
is
essential
inhibiting
osteoclastic
activity
promoting
osteogenesis.
Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: July 31, 2023
Most
bone-related
injuries
to
grassroots
troops
are
caused
by
training
or
accidental
injuries.
To
establish
preventive
measures
reduce
all
kinds
of
trauma
and
improve
the
combat
effectiveness
troops,
it
is
imperative
develop
new
strategies
scaffolds
promote
bone
regeneration.
BMEMat,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 24, 2024
Abstract
With
high
biocompatibility
and
degradability,
polysaccharide‐based
hydrogels
are
favorable
healthcare
materials.
However,
in
many
biomedical
applications,
these
materials
inconvenient
to
handle
with
fixed
morphology,
unable
closely
match
the
wounds,
easy
detach
due
insufficient
adhesion.
Inspired
by
superior
wet
adhesive
properties
of
marine
mussels,
researchers
have
used
mussel‐inspired
chemistry
create
mussel‐mimetic
injectable
that
simple
operate,
controllable
shape,
highly
adhesive,
significantly
extended
their
applications
such
as
tissue
adhesives,
delivery
vehicles,
engineering
scaffolds,
wearable
sensors.
there
few
comprehensive
reviews
on
both
adhesion
injectability,
critical
analyses
hydrogels'
preparation
methods
applications.
This
review
fills
this
gap
systematically
summarizes
strategies
for
novel
hydrogels,
including
modifying
polysaccharides
catechol‐
or
pyrogallol‐containing
small
molecules
leveraging
different
interactions
between
catechol‐/pyrogallol‐modified
other
substances
form
crosslinked
hydrogels.
Furthermore,
recent
discussed,
future
challenges
research
trends
proposed.
Materials & Design,
Journal Year:
2023,
Volume and Issue:
233, P. 112268 - 112268
Published: Aug. 22, 2023
The
bio-inertness
of
titanium
(Ti)
and
the
accompanying
severe
inflammation
can
extremely
inhibit
coupled
osteogenesis-angiogenesis
regulation
result
in
undesirable
osseointegration
peri-implant
during
implantation
process.
Herein,
three
types
TiO2
nanotubes
(TNT)
were
prepared
on
native
Ti
substrates
using
anodic
oxidation
approach,
including
TNT
with
a
diameter
30
nm
(TNT-30),
70
(TNT-70),
110
(TNT-110).
Among
four
substrates,
TNT-70
was
most
prominent
to
induce
differentiation
macrophages
pro-healing
M2
phenotype
via
significant
down-regulation
pro-inflammation
genes
(CD86,
iNOS,
CD11c)
cytokines
(TNF-α,
IL-6),
as
well
up-regulation
anti-inflammation
(CD206,
Arg-1,
IL-10)
(TGF-β,
IL-10).
Furthermore,
could
stimulate
osteogenic
potential
mesenchymal
stem
cells
(MSCs)
angiogenic
ability
human
umbilical
vein
endothelial
(HUVECs)
through
multiple
paracrine
signaling.
In
vivo
experiments
suggested
that
significantly
relieved
early
inflammatory
response
around
implant
facilitated
osteogenesis
angiogenesis,
effectively
promoted
peri-implant.
This
study
provided
reference
for
fabricating
surface
topography
implants
improving
relieving
associated
excessive
responses.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 9100 - 9100
Published: Aug. 22, 2024
The
impressive
adhesive
capacity
of
marine
mussels
has
inspired
various
fascinating
designs
in
biomedical
fields.
Mussel-inspired
injectable
hydrogels,
as
a
type
promising
mussel-inspired
material,
have
attracted
much
attention
due
to
their
minimally
invasive
property
and
desirable
functions
provided
by
components.
In
recent
decades,
hydrogels
been
designed
widely
applied
numerous
rational
incorporation
catechol
groups
endows
the
with
potential
exhibit
many
properties,
including
tissue
adhesiveness
self-healing,
antimicrobial,
antioxidant
capabilities,
broadening
applications
this
review,
we
first
give
brief
introduction
adhesion
mechanism
characteristics
hydrogels.
Further,
typical
design
strategies
are
summarized.
methodologies
for
integrating
into
polymers
crosslinking
methods
discussed
section.
addition,
systematically
overview
applications,
focus
on
how
unique
properties
these
benefit
challenges
perspectives
last
This
review
may
provide
new
inspiration
novel
bioinspired
facilitate
application
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(15), P. 19391 - 19410
Published: April 9, 2024
Nowadays,
bone
systems
have
a
series
of
consequences
that
compromise
the
quality
life
mainly
due
to
wear
and
decreased
bioactivity,
generally
in
elderly
people
children.
In
this
context,
combination
montmorillonite
(MMT-NPs)
vitreous
system
such
as
nanobioglass
facilitates
adsorption
biomolecules
on
surface
within
interlamellar
spaces,
enabling
entry
ions
by
cation
exchange
process
focusing
increasing
rate
formation.
This
work
aims
synthesize
characterize
an
eco-friendly
hybrid
reinforcement
containing
MMT-NPs
with
doped
magnesium
nanoparticles
(MgNPs-BV).
way,
MMT-NPs@MgNPs-BV
was
synthesized
impregnation
method,
where
experimental
design
used
verify
synthesis
conditions.
The
ideal
condition
carried
out
terms
characterization
biological
activity,
we
demonstrated
30%
w
