Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Abstract
Bacterial
infection
has
become
the
most
dangerous
factor
in
tissue
repair,
which
strongly
affects
regeneration
efficiency
and
wellness
of
patients.
Piezoelectric
materials
exhibit
outstanding
advantage
producing
electrons
without
external
power
supply.
The
ability
electron
enrichment
reactive
oxygen
species
generation
through
noninvasive
stimulations
enables
piezoelectric
potential
applications
antibacterial.
Many
studies
have
proved
feasibility
as
a
functional
addition
antibacterial
biomaterial.
In
fact,
numerous
with
ingenious
designs
are
reported
to
be
effective
processes.
This
review
summarizes
mechanisms
piezoelectric,
illuminating
their
combating
bacteria.
Recent
advancement
design
construction
biomaterial
including
defect
engineering,
heterojunction,
synergy
metal
composite
scaffold
configuration
thoroughly
reviewed.
Moreover,
therapeutic
effects
common
tissues
requirements
introduced,
such
orthopedics,
dental,
wound
healing.
Finally,
development
prospects
points
deserving
further
exploration
listed.
is
expected
provide
valuable
insight
into
relationship
between
processes
materials,
inspiring
constructive
this
emerging
scientific
discipline.
Engineered Regeneration,
Год журнала:
2023,
Номер
5(1), С. 21 - 44
Опубликована: Окт. 27, 2023
Bone
fractures
are
common
occurrence
in
clinical
settings,
creating
a
high
demand
for
effective
repair
material.
Unfortunately,
limited
graft
availability,
donor
site
morbidities,
unpredictable
outcomes,
immunologic
reactions,
infection
risks,
and
geometrical
mismatching
concerns
hampered
tissue
use
underscored
the
need
scaffolds
more
bone
reconstructions
due
to
their
tunable
properties.
Significant
progress
has
been
carried
out
past
decade
fields
of
nanoceramics
synthesis,
bioconjugate
chemistry,
composite
material
processing.
This
review
outlines
hierarchical
structures
biology
tissue,
materialistic
components
(bioceramics,
polymers,
bioactive
drugs),
featured
scaffolding
strategies
(nanofibers,
hydrogels,
aerogels,
bioprinting,
fiber-reinforced
composite),
emphasis
that
physiochemical
characteristics
should
be
used
as
an
inspiration
scaffold
design.
discussed
how
differences
materiobiological
aspects
scaffolds,
such
polymer/bioceramic
nanocomposite,
mineralized
matrix-rich
3D
microenvironmental
cues,
pore
space
mechanical
usage
physical
stimulation
(magnetic,
electroactive,
photoactivated
cues),
surface
cues
(wettability,
roughness,
textured,
charge),
biointerface
(cell–biomaterial
interactions,
cell-selective
homing,
cell
regulatory
strategies)
modulate
cellular
biological
response
engineering.
study
further
challenges
benefits
integrating
Alexandria Engineering Journal,
Год журнала:
2023,
Номер
87, С. 277 - 299
Опубликована: Дек. 28, 2023
Conjugated
polymers
such
as
polypyrrole,
polyaniline,
and
polythiophene
have
developed
capable
candidates
for
scaffold
fabrication
due
to
their
electrical
conductivity,
tunable
surface
properties,
ability
deliver
bioactive
molecules.
When
blended
with
other
biomaterials
nanoparticles
enables
the
formation
of
composites
that
leverage
advantages
both
components.
The
main
focus
areas
review
include
use
conjugated
polymer-based
(CPCs)
tissue
engineering
e.g.,
neural,
cardiac,
bone,
skin.
Within
each
section,
specific
examples
are
provided
polymer-biomolecule
composite
systems
been
explored
along
a
discussion
composition,
fabrication,
performance
supporting
cell
growth
regeneration.
Finally,
current
challenges
future
perspectives
discussed
in
applying
CPCs
toward
clinically
relevant
tissues
organs.
Overall,
this
comprehensive
covers
fundamental
design
considerations
developing
polymer
scaffolds
emerging
applications
engineering.
Advanced Materials,
Год журнала:
2024,
Номер
36(45)
Опубликована: Сен. 13, 2024
Abstract
Osteochondral
injury
is
a
prevalent
condition
for
which
no
specific
treatment
currently
available.
This
study
presents
piezoelectric‐conductive
scaffold
composed
of
piezoelectric
cartilage‐decellularized
extracellular
matrix
(dECM)
and
modified
gelatin
(Gel‐PC).
The
piezoelectricity
the
achieved
through
modification
diphenylalanine
(FF)
assembly
on
pore
surface,
while
conductive
properties
are
by
incorporating
poly(3,4‐ethylenedioxythiophene).
In
vitro
experiments
demonstrate
that
bone
marrow
mesenchymal
stem
cells
(BMSCs)
undergo
biphasic
division
during
differentiation.
vivo
studies
using
Parma
pig
model
osteochondral
defects
exhibits
superior
reparative
efficacy.
Notably,
generation
electrical
stimulation
linked
to
joint
movement.
During
activity,
mechanical
forces
compress
scaffold,
leading
deformation
subsequent
an
electric
potential
difference.
positive
charges
accumulated
upper
layer
attract
BMSCs,
promoting
their
migration
chondrogenic
Meanwhile,
negative
in
lower
induce
osteogenic
differentiation
BMSCs.
Overall,
this
piezoelectric‐conducive
provides
promising
platform
effective
repair
defects.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 12, 2024
Abstract
Background
Coordination
between
osteo-/angiogenesis
and
the
osteoimmune
microenvironment
is
essential
for
effective
bone
repair
with
biomaterials.
As
a
highly
personalized
precise
biomaterial
suitable
repairing
complex
defects
in
clinical
practice,
it
to
endow
3D-printed
scaffold
above
key
capabilities.
Results
Herein,
by
introducing
xonotlite
nanofiber
(Ca
6
(Si
O
17
)
(OH)
2
,
CS)
into
silk
fibroin/gelatin
basal
scaffold,
novel
system
named
SGC
was
fabricated.
It
noted
that
incorporation
of
CS
could
greatly
enhance
chemical
mechanical
properties
match
needs
regeneration.
Besides,
benefiting
from
addition
CS,
scaffolds
accelerate
osteo-/angiogenic
differentiation
mesenchymal
stem
cells
(BMSCs)
meanwhile
reprogram
macrophages
establish
favorable
microenvironment.
In
vivo
experiments
further
demonstrated
efficiently
stimulate
create
regeneration-friendly
Mechanistically,
we
discovered
may
achieve
immune
reprogramming
through
decrease
expression
Smad6
Smad7,
both
which
participate
transforming
growth
factor-β
(TGF-β)
signaling
pathway.
Conclusion
Overall,
this
study
potential
due
its
pro-osteo-/angiogenic
osteoimmunomodulatory
properties.
addition,
promising
strategy
develop
biomaterials
taking
osteoinduction
remodeling
functions
account.
Graphical
Materials Today Chemistry,
Год журнала:
2024,
Номер
37, С. 102016 - 102016
Опубликована: Апрель 1, 2024
Tissue-engineered
constructs
can
replicate
the
structural
and
physiological
properties
of
natural
tissues.
The
be
designed
to
address
transplantation
issues
affected
by
shortage
donor
tissues
organs.
One
major
concerns
in
tissue
engineering
is
design
development
structures
that
improve
interaction
between
materials
cells
provide
an
ideal
platform
for
form
functional
tissue.
Several
contributing
factors
need
considered
fabricate
constructs,
including
biomaterials,
biological,
topographical,
biophysical,
morphological
either
alone
or
combination.
Here,
we
review
application,
advancement,
future
directions
these
essential
designing
developing
regeneration.
In
particular,
focus
on
original
approaches
tools
construct
parameters
engineering.
Abstract
Nanoparticles
(NPs)
are
particles
with
unique
features
that
have
been
used
in
a
variety
of
fields,
including
healthcare,
farming,
and
the
food
industry.
Recent
research
has
shown
many
possible
uses
for
nanoparticles,
gas
sensors,
waste
management,
preservation,
high-temperature
superconductors,
field
emission
emitters,
processing,
packaging,
agriculture.
application
is
connected
nutritive,
coating,
sensory
properties
compounds.
specific
anticancer,
antibacterial,
antioxidant
activity,
making
them
an
attractive
tool
biomedical
applications.
Because
their
extraordinary
mechanical,
magnetic,
electric,
thermal,
electric
capabilities,
some
nanoparticles
more
important
than
others.
Numerous
sectors
agriculture,
industry,
environment,
medicine,
fungicidal,
nematicidal
therapy,
catalysis,
color
degradation.
Furthermore,
synthesis
method
crucial
final
nanosystem’s
characteristics.
Food
businesses
frequently
employ
nano-coating
to
prevent
spoiling.
The
various
NP
techniques
numerous
applications
relevant
sector
therefore
briefly
explored.
This
review
gives
us
overview
different
methods
fields
biotechnology
such
as
nanomedicine,
tissue
engineering,
Graphical
abstract
