The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence

Cell Host & Microbe, Год журнала: 2020, Номер 28(2), С. 180 - 189

Опубликована: Авг. 1, 2020

Язык: Английский

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Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases

Nutrients, Год журнала: 2018, Номер 10(6), С. 708 - 708

Опубликована: Июнь 1, 2018

In recent years evidence has emerged that neurodegenerative diseases (NDs) are strongly associated with the microbiome composition in gut. Parkinson’s disease (PD) is most intensively studied this context. review, we performed a systematic evaluation of published literature comparing changes colonic PD to ones observed other NDs including Alzheimer’s (AD), multiple system atrophy (MSA), sclerosis (MS), neuromyelitis optica (NMO) and amyotrophic lateral (ALS). To enhance comparability different studies, only human case-control studies were included. Several showed an increase Lactobacillus, Bifidobacterium, Verrucomicrobiaceae Akkermansia PD. A decrease Faecalibacterium spp., Coprococcus Blautia Prevotella spp. Prevotellaceae was On low taxonomic resolution, like phylum level, not disease-specific inconsistent. However, on higher resolution genus or species minor overlap between MSA, both alpha synucleinopathies. We show standardization sample collection analysis necessary for ensuring reproducibility data. also provide assessing microbiota at high reveals relative abundance may be specific characteristic one group, might evolve discriminative power. The interactions bacterial strains co-abundances must investigated before assumptions about effects bacteria host can made certainty.

Язык: Английский

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Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies

Journal of Functional Foods, Год журнала: 2017, Номер 33, С. 194 - 201

Опубликована: Март 29, 2017

Язык: Английский

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Potential for enriching next-generation health-promoting gut bacteria through prebiotics and other dietary components

Gut Microbes, Год журнала: 2019, Номер 11(1), С. 1 - 20

Опубликована: Май 22, 2019

The human intestinal commensal microbiota and associated metabolic products have long been regarded as contributors to host health. As the identity activities of various members this community become clearer, newly identified health-associated bacteria, such Faecalibacterium prausnitzii, Akkermansia muciniphila, Ruminococcus bromii Roseburia species, emerged. Notably, abundance many these bacteria is inversely correlated several disease states. While technological regulatory hurdles may limit use strains from taxa probiotics, it should be possible utilize prebiotics other dietary components selectively enhance their growth in situ. Dietary potential relevance include well-established prebiotics, galacto-oligosaccharides, fructo-oligosaccharides inulin, while putative oligosaccharides, polyphenols, resistant starch, algae seaweed well gut metabolites lactate acetate, also applied with aim and/or differentially affecting beneficial bacterial within gastrointestinal environment. present review provides an overview that could manner.

Язык: Английский

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Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice

Science Translational Medicine, Год журнала: 2020, Номер 12(567)

Опубликована: Окт. 28, 2020

High-sugar diet promotes the growth of mucolytic bacteria, leading to reduction mucus layer and predisposition colitis in mice.

Язык: Английский

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