Reactive Oxygen Species and NRF2 Signaling, Friends or Foes in Cancer?

Biomolecules, Год журнала: 2023, Номер 13(2), С. 353 - 353

Опубликована: Фев. 11, 2023

The imbalance between reactive oxygen species (ROS) production and clearance causes oxidative stress ROS, which play a central role in regulating cell tissue physiology pathology. Contingent upon concentration, ROS influence cancer development contradictory ways, either stimulating survival growth or causing death. Cells developed evolutionarily conserved programs to sense adapt redox the fluctuations regulate as signaling molecules toxic insults. transcription factor nuclear erythroid 2-related 2 (NRF2)-KEAP1 system is master regulator of cellular metabolic homeostasis. NRF2 has Janus-like roles carcinogenesis development. Short-term activation suppresses injury, inflammation, initiation. However, cells often exhibit constitutive due genetic mutations oncogenic signaling, conferring advantages for cells' growth. Emerging evidence suggests that hyperactivation, an adaptive phenotype under stressful tumor environments, regulates all hallmarks cancer. In this review, we summarized source regulation sensors (O2), reviewed recent progress on generation with focus new functions reach beyond what originally envisioned, including metabolism, autophagy, macropinocytosis, unfolded protein response, proteostasis, circadian rhythm, which, together anti-oxidant drug detoxification enzymes, contributes development, metastasis, anticancer therapy resistance.

Язык: Английский

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Regulation of antioxidants in cancer

Molecular Cell, Год журнала: 2023, Номер 84(1), С. 23 - 33

Опубликована: Ноя. 28, 2023

Язык: Английский

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Nanozyme‐Based Regulation of Cellular Metabolism and Their Applications

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Апрель 5, 2023

Metabolism is the sum of enzyme-dependent chemical reactions, which produces energy in catabolic process and synthesizes biomass anabolic process, exhibiting high similarity mammalian cell, microbial plant cell. Consequently, loss or gain metabolic enzyme activity greatly affects cellular metabolism. Nanozymes, as emerging mimics with diverse functions adjustable catalytic activities, have shown attractive potential for regulation. Although basic tasks are highly similar cells from different species, concrete pathway varies intracellular structure species. Here, metabolism living organisms described similarities differences pathways among mammalian, microbial, regulation mechanism discussed. The recent progress on mainly including nutrient uptake utilization, production, accompanied redox reactions by kinds oxidoreductases their applications field disease therapy, antimicrobial sustainable agriculture systematically reviewed. Furthermore, prospects challenges nanozymes regulating cell also discussed, broaden application scenarios.

Язык: Английский

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Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo

ACS Nano, Год журнала: 2024, Номер 18(5), С. 3916 - 3968

Опубликована: Янв. 23, 2024

Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.

Язык: Английский

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ROS Balance Autoregulating Core–Shell CeO2@ZIF-8/Au Nanoplatform for Wound Repair

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Март 21, 2024

Reactive oxygen species (ROS) plays important roles in living organisms. While ROS is a double-edged sword, which can eliminate drug-resistant bacteria, but excessive levels cause oxidative damage to cells. A core-shell nanozyme, CeO

Язык: Английский

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