Current Issues in Molecular Biology,
Год журнала:
2022,
Номер
44(8), С. 3413 - 3427
Опубликована: Июль 30, 2022
Excessive
lipid
deposition
in
layer
chickens
due
to
inappropriate
feeding
adversely
affects
egg
production;
however,
nutritional
manipulation
methods
deal
with
this
issue
are
still
limited.
β-hydroxy-β-methylbutyrate
(HMB),
a
metabolite
of
L-leucine,
was
recently
reported
as
lipid-lowering
nutrient
mice
and
pigs,
although
its
role
layers
had
not
been
investigated.
Here,
we
employed
high-fat
high-cholesterol
diet
(HFHCD)-challenged
growing
an
obese
model
explore
HMB
function
the
regulation
metabolism
potential
mechanisms
involved.
We
found
that
dietary
supplementation
(0.05%
or
0.10%)
significantly
reduced
HFHCD-induced
bodyweight
growth
layers,
mainly
reduction
abdominal
fat
deposition.
Mechanistically,
enhanced
hepatic
bile
acid
synthesis
from
cholesterol
through
elevating
expression
Cyp7a1,
gene
coding
key
enzyme
synthesis.
Furthermore,
16S
rRNA
sequencing
revealed
remodeled
diversity
composition
layers'
cecal
microbiota,
abundance
Bacteroidetes
at
phylum
level
were
especially
affected.
Correlation
analysis
further
indicated
strong
negative
association
between
metabolism-related
parameters.
Taken
together,
these
data
suggest
could
improve
probably
modulating
gut
microbiota
function.
Microorganisms,
Год журнала:
2022,
Номер
10(7), С. 1368 - 1368
Опубликована: Июль 7, 2022
There
is
increasing
evidence
that
diet
influences
the
relationship
between
gut
microbiota
and
individual
health
outcomes.
Nutrient
intake
affects
composition
of
microbial
community
provides
metabolites
influence
host
physiology.
Dietary
patterns,
including
macronutrient
balance
feeding/fasting
cycles
which
may
be
manipulated
with
dietary
regimens
based
on
caloric
restriction
periods,
homeostasis
through
its
impact
ecosystem.
Along
same
line,
prebiotic
probiotic
ingredients
additives
in
foods,
as
well
degree
food
processing
have
consequences
related
immune
metabolic
response
human
host.
Acquiring
knowledge
these
aspects,
especially
an
-omics-integral
approach,
might
provide
basis
for
personalized
nutritional
interventions
directed
to
avoid
dysbiosis
contribute
prevention
major
chronic
degenerative
diseases.
Despite
vast
scientific
supporting
factors
function,
underlying
mechanisms
their
potential
are
far
from
clear.
a
lack
well-designed
longitudinal
studies
performed
target
population
groups
whose
patterns
can
particularly
relevant
future
health,
case
infants,
pregnant
women,
or
athletes.
Cells,
Год журнала:
2022,
Номер
11(12), С. 1883 - 1883
Опубликована: Июнь 10, 2022
Obesity
is
characterized
by
an
increase
in
body
weight
associated
with
exaggerated
enlargement
of
the
adipose
tissue.
has
serious
negative
effects
because
it
multiple
pathological
complications
such
as
type
2
diabetes
mellitus,
cardiovascular
diseases,
cancer,
and
COVID-19.
Nowadays,
39%
world
population
obese
or
overweight,
making
obesity
21st
century
epidemic.
also
a
mild,
chronic,
systemic
inflammation.
Accumulation
fat
tissue
causes
stress
malfunction
adipocytes,
which
then
initiate
Next,
infiltrated
cells
innate
immune
system.
Recently,
become
evident
that
neutrophils,
most
abundant
leukocytes
blood,
are
first
infiltrating
Neutrophils
get
activated
release
inflammatory
factors
recruit
macrophages
other
cells.
These
cells,
turn,
perpetuate
inflammation
state
producing
cytokines
chemokines
can
reach
parts
body,
creating
condition.
In
this
review,
we
described
recent
findings
on
role
neutrophils
during
initiation
addition,
discuss
involvement
generation
obesity-related
using
prime
example.
Nutrients,
Год журнала:
2022,
Номер
14(19), С. 4116 - 4116
Опубликована: Окт. 3, 2022
A
polysaccharide
is
a
macromolecule
composed
of
more
than
ten
monosaccharides
with
wide
distribution
and
high
structural
diversity
complexity
in
nature.
Certain
polysaccharides
are
immunomodulators
play
key
roles
the
regulation
immune
responses
during
progression
some
diseases.
In
addition
to
stimulating
growth
certain
intestinal
bacteria,
may
also
promote
health
benefits
by
modulating
gut
microbiota.
last
years,
studies
about
triad
microbiota–polysaccharides–health
have
increased
exponentially.
consequence,
present
review,
we
aim
summarize
recent
knowledge
function
dietary
on
microbiota
composition
how
these
effects
affect
host
health.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Ноя. 9, 2022
Polysaccharides
are
the
most
diverse
molecules
and
can
be
extracted
from
abundant
edible
materials.
Increasing
research
has
been
conducted
to
clarify
structure
composition
of
polysaccharides
obtained
different
materials
their
effects
on
human
health.
Humans
only
directly
assimilate
very
limited
polysaccharides,
which
conveyed
distal
gut
fermented
by
intestinal
microbiota.
Therefore,
main
mechanism
underlying
bioactive
health
involves
interaction
between
Recently,
interest
in
role
health,
obesity,
related
disorders
increased
due
wide
range
valuable
biological
activities
polysaccharides.
The
known
roles
include
mechanisms
that
microbiota-dependent
involve
microbiota-derived
metabolites
microbiota-independent.
In
this
review,
we
discuss
metabolic
diseases
mechanisms.
findings
review
provide
information
functional
facilitate
dietary
recommendations
for
people
with
issues.
To
uncover
more
clinical
trials
should
confirm
therapeutic
disease.
Greater
attention
directed
toward
polysaccharide
extraction
by-products
or
derived
food
processing
unsuitable
direct
consumption,
rather
than
extracting
them
advanced
understanding
mutualistic
microbes,
microbiota-fermenting
subsequent
outcomes
insight
into
proper
application
improving
Circulation Research,
Год журнала:
2023,
Номер
132(12), С. 1674 - 1691
Опубликована: Июнь 8, 2023
Cardiometabolic
disease
comprises
cardiovascular
and
metabolic
dysfunction
underlies
the
leading
causes
of
morbidity
mortality,
both
within
United
States
worldwide.
Commensal
microbiota
are
implicated
in
development
cardiometabolic
disease.
Evidence
suggests
that
microbiome
is
relatively
variable
during
infancy
early
childhood,
becoming
more
fixed
later
childhood
adulthood.
Effects
microbiota,
development,
life,
may
induce
changes
host
metabolism
modulate
risk
mechanisms
predispose
toward
In
this
review,
we
summarize
factors
influence
gut
composition
function
life
explore
how
microbial
throughout
life.
We
highlight
limitations
current
methodology
approaches
outline
state-of-the-art
advances,
which
improving
research
building
refined
diagnosis
treatment
options
microbiome-targeted
therapies.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(6), С. 5369 - 5369
Опубликована: Март 10, 2023
The
metabolic
syndrome
(MS)
is
a
cluster
of
risk
factors,
such
as
central
obesity,
hyperglycemia,
dyslipidemia,
and
arterial
hypertension,
which
increase
the
probability
causing
premature
mortality.
consumption
high-fat
diets
(HFD),
normally
referred
to
high-saturated
fat
diets,
major
driver
rising
incidence
MS.
In
fact,
altered
interplay
between
HFD,
microbiome,
intestinal
barrier
being
considered
possible
origin
Consumption
proanthocyanidins
(PAs)
has
beneficial
effect
against
disturbances
in
However,
there
are
no
conclusive
results
literature
about
efficacy
PAs
improving
This
review
allows
comprehensive
validation
diverse
effects
on
dysfunction
HFD-induced
MS,
differentiating
preventive
therapeutic
actions.
Special
emphasis
placed
impact
gut
microbiota,
providing
system
facilitate
comparison
studies.
can
modulate
microbiome
toward
healthy
profile
strength
integrity.
Nevertheless,
date,
published
clinical
trials
verify
preclinical
findings
scarce.
Finally,
MS-associated
dysbiosis
induced
by
HFD
seems
more
successful
than
treatment
strategy.
