Biomedical applications and prospects of temperature‐orchestrated photothermal therapy DOI Creative Commons
Nuo Xu, Xu Zhang, Tingting Qi

и другие.

MedComm – Biomaterials and Applications, Год журнала: 2022, Номер 1(2)

Опубликована: Сен. 1, 2022

Abstract Photothermal therapy (PTT) has been regarded as a promising strategy considering its advantages of high inherent specificity and lower invasive burden. Since the photothermal killing cells/bacteria showed different patterns death depending on varying temperature in PTT, change PTT is vital to cell/tissue response scientific research clinical application. On one hand, mild received substantial attention treatment cancer soft/hard tissue repair. other induced by capable antibacterial capacity, which better than conventional antibiotic with drug resistance. Herein, we summarize recent developments application temperature‐dependent biomaterials, mainly covering ranges 40–42°C, 43–50°C, over 50°C. We highlight biological mechanism latest progress diseases. Finally, conclude discussing challenges perspectives biomaterials addressing temperature‐orchestrated PTT. Given deep understanding interaction between biology, rationally designed sophisticated responsiveness will benefit outcomes personalized toward various

Язык: Английский

Bioinspired polydopamine hydrogels: Strategies and applications DOI
Yuanting Xu, Junfei Hu, Jingjing Hu

и другие.

Progress in Polymer Science, Год журнала: 2023, Номер 146, С. 101740 - 101740

Опубликована: Сен. 17, 2023

Язык: Английский

Процитировано

110
Smart/stimuli-responsive hydrogels: State-of-the-art platforms for bone tissue engineering DOI

Hussein M. El‐Husseiny,

Eman A. Mady, Walaa A. El‐Dakroury

и другие.

Applied Materials Today, Год журнала: 2022, Номер 29, С. 101560 - 101560

Опубликована: Июнь 22, 2022

Язык: Английский

Процитировано

86
Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment DOI Creative Commons

Weikai Chen,

Hao Zhang,

Qirong Zhou

и другие.

Research, Год журнала: 2023, Номер 6

Опубликована: Янв. 1, 2023

Rapid and effective repair of injured or diseased bone defects remains a major challenge due to shortages implants. Smart hydrogels that respond internal external stimuli achieve therapeutic actions in spatially temporally controlled manner have recently attracted much attention for therapy regeneration. These can be modified by introducing responsive moieties embedding nanoparticles increase their capacity repair. Under specific stimuli, smart variable, programmable, controllable changes on demand modulate the microenvironment promoting healing. In this review, we highlight advantages summarize materials, gelation methods, properties. Then, overview recent advances developing biochemical signals, electromagnetic energy, physical including single, dual, multiple types enable physiological pathological modulating microenvironment. discuss current challenges future perspectives regarding clinical translation hydrogels.

Язык: Английский

Процитировано

58
Leveraging the Recent Advancements in GelMA Scaffolds for Bone Tissue Engineering: An Assessment of Challenges and Opportunities DOI
Narsimha Mamidi,

Fatemeh Ijadi,

Mohammad Hadi Norahan

и другие.

Biomacromolecules, Год журнала: 2023, Номер 25(4), С. 2075 - 2113

Опубликована: Июль 5, 2023

The field of bone tissue engineering has seen significant advancements in recent years. Each year, over two million transplants are performed globally, and conventional treatments, such as grafts metallic implants, have their limitations. Tissue offers a new level treatment, allowing for the creation living within biomaterial framework. Recent advances biomaterials provided innovative approaches to rebuilding function after damage. Among them, gelatin methacryloyl (GelMA) hydrogel is emerging promising supporting cell proliferation regeneration, GelMA exhibited exceptional physicochemical biological properties, making it viable option clinical translation. Various methods classes additives been used application with incorporation nanofillers or other polymers enhancing its resilience functional performance. Despite results, fabrication complex structures that mimic architecture provision balanced physical properties both vasculature growth proper stiffness load bearing remain challenges. In terms utilizing osteogenic additives, priority should be on versatile components promote angiogenesis osteogenesis while reinforcing structure applications. This review focuses efforts advantages GelMA-based composite engineering, covering literature from last five

Язык: Английский

Процитировано

48
Strategies of functionalized GelMA-based bioinks for bone regeneration: Recent advances and future perspectives DOI Creative Commons

Yaru Zhu,

Xingge Yu,

Hao Liu

и другие.

Bioactive Materials, Год журнала: 2024, Номер 38, С. 346 - 373

Опубликована: Май 9, 2024

Gelatin methacryloyl (GelMA) hydrogels is a widely used bioink because of its good biological properties and tunable physicochemical properties, which has been in variety tissue engineering regeneration. However, pure GelMA limited by the weak mechanical strength lack continuous osteogenic induction environment, difficult to meet needs bone repair. Moreover, are unable respond complex stimuli therefore adapt physiological pathological microenvironments. This review focused on functionalization strategies hydrogel based bioinks for The synthesis process was described details, various functional methods requirements regeneration, including strength, porosity, vascularization, differentiation, immunoregulation patient specific repair, etc. In addition, response smart GelMA-based external physical stimulation internal microenvironment stimulation, as well achieve both disease treatment regeneration presence common diseases (such inflammation, infection, tumor) also briefly reviewed. Finally, we emphasized current challenges possible exploration directions

Язык: Английский

Процитировано

30
Biomaterials for diabetic bone repair: Influencing mechanisms, multi-aspect progress and future prospects DOI
Bingbing Wang, Yong Huang,

Qiang Cai

и другие.

Composites Part B Engineering, Год журнала: 2024, Номер 274, С. 111282 - 111282

Опубликована: Фев. 5, 2024

Язык: Английский

Процитировано

17
Photothermal nanohybrid hydrogels for biomedical applications DOI Creative Commons
Fan Ding, Linlin Zhang, Xu Chen

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10

Опубликована: Ноя. 3, 2022

In the past decades, diseases such as wound infection, cancer, bone defect and osteoarthritis have constantly threatened public health. However, traditional treatment has many insufficiencies, high cost, easy recurrence biological toxicity. Hydrogel is a material with three-dimensional network structure, which series of advantages, injectability, self-heal ability, loading controllability drug release, excellent biocompatibility. Therefore, it extensively used in delivery, antibacterial, anti-cancer other fields. hydrogels single performance, therapeutic efficacy often rely on drugs loaded them to cure diseases, cannot achieve sustainable effect. order solve this problem, photothermal nano hydrogel agent (PTA) become an ideal due its physical chemical properties. Photothermal therapy (PTT) can exploit effect increase local temperature control sol-gel phase transition behavior hydrogels, so they are widely sterilization, inhibition cancer cells enhancement repair. To sum up, paper introduces preparation nanomaterials, discusses their applications fields cell enhanced

Язык: Английский

Процитировано

41
Materials‐Mediated In Situ Physical Cues for Bone Regeneration DOI
Shuo Liu,

Liguo Zhang,

Zhao Li

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 34(1)

Опубликована: Сен. 15, 2023

Abstract Physical cues like morphology, light, electric signal, mechanic magnetic and heat can be used as alternative regulators for expensive but short‐acting growth factors in bone tissue engineering to promote osteogenic differentiation regeneration. As physical stimulation applied directly the cannot focused on defect area regulate cell behaviors fate situ, this limits efficiency of precise Biomaterials‐mediated situ cues, an effective strategy combining synergistic effect materials themselves, are put forward studied widely repair efficiently precisely. Different types provide different choices better satisfy requirements targeted repair. In review, recent research about biomaterials‐mediated accelerating osteogenesis vitro promoting formation vivo is introduced. Meanwhile, corresponding possible mechanisms various regulating responses also discussed. This review provides useful enlightening guidance utilization intrinsically properties functional achieve efficient regeneration, leading design construction smart biomaterials practical applications, eventually clinical translation.

Язык: Английский

Процитировано

39
Injectable Biomimetic Hydrogel Guided Functional Bone Regeneration by Adapting Material Degradation to Tissue Healing DOI
Yamin Li, Lan Xiao, Dai‐Xu Wei

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 33(19)

Опубликована: Март 4, 2023

Abstract The treatment of irregular bone defects remains a clinical challenge since the current biomaterials (e.g., calcium phosphate cement (CPC)) mainly act as inert substitutes, which are incapable transforming into regenerated host (termed functional regeneration). Ideally, implant degradation rate should adapt to that regeneration, therefore providing sufficient physicochemical support and giving space for growth. This study aims develop an injectable biomaterial with regeneration‐adapted degradability, reconstruct biomimetic bone‐like structure can timely transform new bone, facilitating regeneration. To achieve this goal, hybrid (LP‐CPC@gelatin, LC) hydrogel is synthesized via one‐step incorporation laponite (LP) CPC gelatin hydrogel, LC gel controlled by adjusting LP/CPC ratio match regeneration rate. Such shows good osteoinduction, osteoconduction, angiogenesis effects, complete implant‐to‐new transformation capacity. 2D nanoclay‐based bionic induce ectopic promote ligament graft osseointegration in vivo inducing Therefore, provides advanced strategy skeletal muscle repair minimally invasive therapy.

Язык: Английский

Процитировано

35
Zinc based biodegradable metals for bone repair and regeneration: Bioactivity and molecular mechanisms DOI Creative Commons
Ping Li, Jingtao Dai, Yageng Li

и другие.

Materials Today Bio, Год журнала: 2023, Номер 25, С. 100932 - 100932

Опубликована: Дек. 28, 2023

Bone fractures and critical-size bone defects are significant public health issues, clinical treatment outcomes closely related to the intrinsic properties of utilized implant materials. Zinc (Zn)-based biodegradable metals (BMs) have emerged as promising bioactive materials because their exceptional biocompatibility, appropriate mechanical properties, controllable biodegradation. This review summarizes state art in terms Zn-based for repair regeneration, focusing on bridging gap between biological mechanism required bioactivity. The molecular underlying release Zn ions from BMs improvement regeneration is elucidated. By integrating considerations specific bioactivity materials, this current research status internal fixation promoting fracture healing, scaffolds regenerating defects, barrier membranes reconstituting alveolar defects. Considering progress made potential applications, challenges directions proposed discussed.

Язык: Английский

Процитировано

34