Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)

Опубликована: Сен. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Язык: Английский

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Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 167, С. 115464 - 115464

Опубликована: Сен. 15, 2023

Luteolin is a flavonoid widely present in various traditional Chinese medicines. In recent years, luteolin has received more attention due to its impressive liver protective effect, such as metabolic associated fatty disease, hepatic fibrosis and hepatoma. This article summarizes the pharmacological effects, pharmacokinetic characteristics, toxicity of against diseases, provides prospect. The results indicate that improves lesions through mechanisms, including inhibiting inflammatory factors, reducing oxidative stress, regulating lipid balance, slowing down excessive aggregation extracellular matrix, inducing apoptosis autophagy cancer cells. Pharmacokinetics research manifested bioavailability relatively low. It worth noting appropriate modification, new delivery systems, derivatives can enhance bioavailability. Although many studies have shown minimal, strict experiments are still needed evaluate safety promote reasonable development. addition, this study also discussed clinical applications related luteolin, indicating it key component commonly used drugs practice. view excellent expected become potential drug for treatment diseases.

Язык: Английский

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Luteolin: A promising multifunctional natural flavonoid for human diseases

Phytotherapy Research, Год журнала: 2024, Номер 38(7), С. 3417 - 3443

Опубликована: Апрель 26, 2024

Abstract Natural products are closely associated with human health. Luteolin (LUT), a flavonoid polyphenolic compound, is widely found in fruits, vegetables, flowers, and herbs. It noteworthy that LUT exhibits variety of beneficial pharmacological properties holds significant potential for clinical applications, particularly antitumor, anti‐convulsion, diabetes control, anti‐inflammatory, neuroprotection, anti‐oxidation, anti‐cardiovascular, other aspects. The mechanism action has been partially elucidated, including the mediation NF‐κB, toll‐like receptor, MAPK, Wnt/β‐catenin, PI3K/Akt, AMPK/mTOR, Nrf‐2, among others. review aimed to comprehensively consolidate essential information on natural sources, effects, therapeutic preventive potential, as well mechanisms LUT. objective establish theoretical basis continued development application

Язык: Английский

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The progression of inorganic nanoparticles and natural products for inflammatory bowel disease

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 3, 2024

Abstract There is a growing body of evidence indicating close association between inflammatory bowel disease (IBD) and disrupted intestinal homeostasis. Excessive production reactive oxygen species (ROS) nitrogen (RNS), along with an increase in M1 proinflammatory macrophage infiltration during the activation inflammation, plays pivotal role disrupting homeostasis IBD. The overabundance ROS/RNS can cause tissue damage disruption crucial gut proteins, which ultimately compromises integrity barrier. proliferation macrophages contributes to exaggerated immune response, further compromising Currently, nanomaterials have gained widespread attention context IBD due their notable characteristics, including ability specifically target regions interest, clear excess ROS/RNS, mimic biological enzymes. In this review, we initially elucidated microenvironment Subsequently, delineate therapeutic strategies involving two distinct types nanomedicine, namely inorganic nanoparticles natural product nanomaterials. Finally, present comprehensive overview promising prospects associated application nanomedicine future clinical settings for treatment (graphic abstract). Graphical

Язык: Английский

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The role and mechanism of flavonoid herbal natural products in ulcerative colitis

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 158, С. 114086 - 114086

Опубликована: Дек. 8, 2022

Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine that presents clinically with abdominal pain, mucopurulent stools, and posterior urgency. The lesions UC are mainly concentrated in rectal colonic mucosa submucosa. For patients mild to moderate UC, best pharmacological treatment includes glucocorticoids, immunosuppressants, antibiotics, biologics, but long-term application can have serious toxic side effects. Currently, nearly 40% treated herbal natural products combination traditional medications reduce incidence Flavonoid most widely distributed polyphenols plants fruits, which certain antioxidant anti-inflammatory activities. achieved remarkable efficacy UC. mechanisms related anti-inflammation, promotion mucosal healing, maintenance intestinal immune homeostasis, regulation flora. In this paper, we summarize flavonoid components anti-ulcerative their reported past 10 years, provide basis for rational clinical use development new drugs.

Язык: Английский

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pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance “One Stone Four Birds” Effect of Rhein on Ulcerative Colitis

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(45), С. 50692 - 50709

Опубликована: Ноя. 3, 2022

Rhein (RH), a natural anthraquinone compound, is considered an effective treatment candidate for ulcerative colitis (UC), whose multiple biological activities contribute to UC, including anti-inflammation, antioxidation, intestinal barrier repair, and microflora regulation. However, the application of RH severely limited by its low water solubility, bioavailability, poor colonic targeting. Although some nanoparticles have been developed oral delivery RH, most them mainly highlighted only one effect drug strategies but above activities. Therefore, polysaccharide-based nanodelivery system, comprising chitosan (CS) fucoidan (FU), with pH/reactive oxygen species (ROS) sensitivity mucosal adhesion, was first used load as comprehensive UC. Briefly, RH-F/C-NPs were prepared using polyelectrolyte self-assembly method; average size 233.1 ± 5.7 nm, encapsulation rate 93.67 1.60%. And it could maintain gastric stability release in colon designed pH/ROS contributed structures. Cellular uptake experiments showed that both NCM 460 cells RAW 264.7 had good RH-F/C-NPs. Importantly, effects vivo experiments, results which significantly reduce DSS-induced inflammation inhibiting TLR4/NF-κB-mediated anti-inflammatory pathway, Nrf2/HO-1-mediated antioxidant In addition, pharmacokinetic studies shown F/C-NPs increase plasma concentration accumulation extent. short, this study develop nanosystem dual "one stone four birds" therapeutic on

Язык: Английский

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Self-Homeostasis Immunoregulatory Strategy for Implant-Related Infections through Remodeling Redox Balance

ACS Nano, Год журнала: 2023, Номер 17(5), С. 4574 - 4590

Опубликована: Фев. 22, 2023

Implant-related infections (IRIs) are catastrophic complications after orthopedic surgery. Excess reactive oxygen species (ROS) accumulated in IRIs create a redox-imbalanced microenvironment around the implant, which severely limits curing of by inducing biofilm formation and immune disorders. However, current therapeutic strategies commonly eliminate infection utilizing explosive generation ROS, exacerbates redox imbalance, aggravating disorders promoting chronicity. Herein, self-homeostasis immunoregulatory strategy based on luteolin (Lut)-loaded copper (Cu2+)-doped hollow mesoporous organosilica nanoparticle system (Lut@Cu-HN) is designed to cure remodeling balance. In acidic environment, Lut@Cu-HN continuously degraded release Lut Cu2+. As both an antibacterial immunomodulatory agent, Cu2+ kills bacteria directly promotes macrophage pro-inflammatory phenotype polarization activate response. Simultaneously, scavenges excessive ROS prevent Cu2+-exacerbated imbalance from impairing activity function, thus reducing immunotoxicity. The synergistic effect confers excellent properties Lut@Cu-HN. demonstrated vitro vivo, self-regulates homeostasis through balance remodeling, ultimately facilitating IRI eradication tissue regeneration.

Язык: Английский

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Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Июль 20, 2023

Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because an improperly managed immunological reactivity intestinal microbiota found in GIT. The immune response common commensal microbes plays essential role inflammation related UC synbiotics, and it important element optimal therapy UC. Therefore, i.e., mixture prebiotics probiotics, help control diseased state. Synbiotics alleviate colon by lowering reactive oxygen species (ROS) improving level antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD). Prebiotic supplementation not practice at moment, despite numerous research findings proving that benefits both probiotics encourage their continued existence positioning GIT, with positive effects on human health managing response. However, fact there have been fewer studies treatment different coupled selected prebiotics, outcomes these very favorable. This evidence-based study explores possible ROS, SOD, synbiotics proposed review also focuses alteration gut microbiota, defense tract, management Thus, current article emphasizes oxidative stress signaling GI stress-based pathomechanisms patients, therapies inhibiting stress’ effects.

Язык: Английский

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Oral delivery of porous starch-loaded bilayer microgels for controlled drug delivery and treatment of ulcerative colitis

Carbohydrate Polymers, Год журнала: 2023, Номер 314, С. 120887 - 120887

Опубликована: Апрель 11, 2023

Язык: Английский

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Nanomedicine for T‐Cell Mediated Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 36(22)

Опубликована: Март 25, 2023

T-cell immunotherapy offers outstanding advantages in the treatment of various diseases, and with selection appropriate targets, efficient disease can be achieved. has made great progress, but clinical results show that only a small proportion patients benefit from immunotherapy. The extensive mechanistic work outlines blueprint for using T cells as new option immunotherapy, also presents challenges, including balance between different fractions cells, inherent suppression patterns microenvironment, acquired loss decline viability. diversity, flexibility, intelligence nanomedicines give them potential enhancing Here, how strategies adapted nanomaterials to enhance therapeutic efficacy is discussed. For two pathological states, immunosuppression immune activation, recent advances diseases such cancers, rheumatoid arthritis, systemic lupus erythematosus, ulcerative colitis, diabetes are summarized. With focus on this review highlights treatment, helps advance one's understanding use nanotechnology

Язык: Английский

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