Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 17
Опубликована: Май 15, 2025
For
proper
cellular
growth,
to
prepare
tissue
scaffold
mimicking
the
properties
is
a
significant
challenge.
Bone
vital
organ
supporting
whole
human
body
for
its
function.
The
efficiencies
in
structure
variety
of
reasons
should
properly
be
remedied.
engineering
(BTE)
an
emerging
field
addressing
develop
or
repair
bone
naturally
piezoelectric
material
and
generates
electrical
stimuli
because
mechanical
stress.
Thus,
use
materials
build
great
interest
BTE.
Both
polymers
nanomaterials
(NMs)
are
investigated
this
goal.
In
review,
we
give
overview
recent
advances
NMs
construct
scaffolds
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 19, 2024
There
has
been
increasing
attention
to
produce
porous
scaffolds
that
mimic
human
bone
properties
for
enhancement
of
tissue
ingrowth,
regeneration,
and
integration.
Additive
manufacturing
(AM)
technologies,
i.e.,
three
dimensional
(3D)
printing,
have
played
a
substantial
role
in
engineering
clinical
applications
owing
their
high
level
design
fabrication
flexibility.
To
this
end,
review
article
attempts
provide
detailed
overview
on
the
main
considerations
such
as
permeability,
adhesion,
vascularisation,
interfacial
features
interplay
affect
regeneration
osseointegration.
Physiology
was
initially
explained
followed
by
analysing
impacts
porosity,
pore
size,
permeability
surface
chemistry
defects.
Importantly,
major
3D
printing
methods
employed
substitutes
were
also
discussed.
Advancements
MA
technologies
allowed
production
with
complex
geometries
polymers,
composites
metals
well-tailored
architectural,
mechanical,
mass
transport
features.
In
way,
particular
devoted
reviewing
printed
triply
periodic
minimal
(TPMS)
hierarchical
structure
bones.
overall,
enlighten
pathway
patient-specific
3D-printed
substitutions
osseointegration
capacity
repairing
large
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Abstract
Bacterial
infection
has
become
the
most
dangerous
factor
in
tissue
repair,
which
strongly
affects
regeneration
efficiency
and
wellness
of
patients.
Piezoelectric
materials
exhibit
outstanding
advantage
producing
electrons
without
external
power
supply.
The
ability
electron
enrichment
reactive
oxygen
species
generation
through
noninvasive
stimulations
enables
piezoelectric
potential
applications
antibacterial.
Many
studies
have
proved
feasibility
as
a
functional
addition
antibacterial
biomaterial.
In
fact,
numerous
with
ingenious
designs
are
reported
to
be
effective
processes.
This
review
summarizes
mechanisms
piezoelectric,
illuminating
their
combating
bacteria.
Recent
advancement
design
construction
biomaterial
including
defect
engineering,
heterojunction,
synergy
metal
composite
scaffold
configuration
thoroughly
reviewed.
Moreover,
therapeutic
effects
common
tissues
requirements
introduced,
such
orthopedics,
dental,
wound
healing.
Finally,
development
prospects
points
deserving
further
exploration
listed.
is
expected
provide
valuable
insight
into
relationship
between
processes
materials,
inspiring
constructive
this
emerging
scientific
discipline.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(26)
Опубликована: Фев. 22, 2024
Abstract
Bioceramics
are
vital
for
treating
bone
defects,
and
bioactive
glasses
(exemplified
by
45S5)
calcium
phosphate
ceramics
(CaPs,
exemplified
tricalcium
[β‐TCP])
extensively
explored.
β‐TCP
exhibits
superior
biocompatibility,
degradability,
osteoconductive
properties
than
45S5;
however,
it
lacks
bioactivity,
such
as
mineralization
capability.
To
harness
the
synergies
of
both,
four
3D
printing
bioceramic
scaffolds:
45S5,
70%
45S5
+
30%
TCP,
manufactured.
Furthermore,
investigation
elucidates
correlation
between
their
in
situ
capabilities
intracellular
oscillations
within
macrophages
determines
how
they
impact
macrophage
phenotypic
transitions.
Notably,
during
degradation,
there
is
an
initial
rise
followed
a
decline
ion
concentration,
which
results
macrophages.
In
TCP
group,
early
release
ions
promotes
M1
polarization.
Subsequently,
rapid
causes
decrease
extracellular
ions,
thus
accelerating
transition
to
M2
facilitating
repair.
The
present
study
reveals
novel
mechanism
through
bioceramics
modulate
polarization,
offers
new
insights
into
foreign
body
response
presents
perspective
on
expeditious
progression
toward
tissue
Advanced Materials Technologies,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 13, 2024
Abstract
Piezoelectric
composites
have
received
widespread
attentions
in
the
fields
of
biomedicine
and
vitro
wearable
devices
due
to
their
ability
convert
mechanical
forces
into
charge
signals.
The
preparation
piezoelectric
with
complex
structures
through
3D
printing
technology
can
not
only
effectively
improve
output,
but
also
enable
customized
therapeutic
applications.
This
paper
first
introduces
types
reviews
commonly
used
preparation,
analyzing
advantages
disadvantages
each
technology.
Then,
state‐of‐the‐art
biomedical
applications
composites,
including
drug
sustained‐release,
wound
healing
promotion,
bone
tissue
cells
growth
promoting,
neurorehabilitation
stimulating,
ultrasonic
diagnosis,
vivo
biosensing
sensing,
are
emphasized.
Finally,
main
factors
affecting
printed
outlooked,
an
in‐depth
discussion
on
challenges
toward
analyzed.
review
is
believed
provide
some
fundamental
knowledge
composites.
Tissue Engineering Part B Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Synthetic
bone
transplantation
has
emerged
in
recent
years
as
a
highly
promising
strategy
to
address
the
major
clinical
challenge
of
tissue
defects.
In
this
field,
bioactive
glasses
(BGs)
have
been
widely
recognized
viable
alternative
traditional
substitutes
due
their
unique
advantages,
including
favorable
biocompatibility,
pronounced
bioactivity,
excellent
biodegradability,
and
superior
osseointegration
properties.
This
article
begins
with
comprehensive
overview
development
success
BGs
engineering,
then
focuses
on
composite
reinforcement
systems
biodegradable
metals,
calcium-phosphorus
(Ca-P)-based
bioceramics,
medical
polymers,
respectively.
Moreover,
outlines
some
frequently
used
manufacturing
methods
for
three-dimensional
BG-based
bioscaffolds
highlights
remarkable
achievements
these
scaffolds
field
defect
repair
years.
Lastly,
based
many
potential
challenges
encountered
preparation
application
BGs,
brief
outlook
future
directions
is
presented.
review
may
help
provide
new
ideas
researchers
develop
ideal
reconstruction
functional
recovery.
