Additively manufactured porous scaffolds by design for treatment of bone defects

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 19, 2024

There has been increasing attention to produce porous scaffolds that mimic human bone properties for enhancement of tissue ingrowth, regeneration, and integration. Additive manufacturing (AM) technologies, i.e., three dimensional (3D) printing, have played a substantial role in engineering clinical applications owing their high level design fabrication flexibility. To this end, review article attempts provide detailed overview on the main considerations such as permeability, adhesion, vascularisation, interfacial features interplay affect regeneration osseointegration. Physiology was initially explained followed by analysing impacts porosity, pore size, permeability surface chemistry defects. Importantly, major 3D printing methods employed substitutes were also discussed. Advancements MA technologies allowed production with complex geometries polymers, composites metals well-tailored architectural, mechanical, mass transport features. In way, particular devoted reviewing printed triply periodic minimal (TPMS) hierarchical structure bones. overall, enlighten pathway patient-specific 3D-printed substitutions osseointegration capacity repairing large

Language: Английский

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Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 51, P. 94 - 107

Published: Feb. 4, 2025

Language: Английский

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Macrophage Intracellular “Calcium Oscillations” Triggered Through In Situ Mineralization Regulate Bone Immunity to Facilitate Bone Repair

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)

Published: Feb. 22, 2024

Abstract Bioceramics are vital for treating bone defects, and bioactive glasses (exemplified by 45S5) calcium phosphate ceramics (CaPs, exemplified tricalcium [β‐TCP]) extensively explored. β‐TCP exhibits superior biocompatibility, degradability, osteoconductive properties than 45S5; however, it lacks bioactivity, such as mineralization capability. To harness the synergies of both, four 3D printing bioceramic scaffolds: 45S5, 70% 45S5 + 30% TCP, manufactured. Furthermore, investigation elucidates correlation between their in situ capabilities intracellular oscillations within macrophages determines how they impact macrophage phenotypic transitions. Notably, during degradation, there is an initial rise followed a decline ion concentration, which results macrophages. In TCP group, early release ions promotes M1 polarization. Subsequently, rapid causes decrease extracellular ions, thus accelerating transition to M2 facilitating repair. The present study reveals novel mechanism through bioceramics modulate polarization, offers new insights into foreign body response presents perspective on expeditious progression toward tissue

Language: Английский

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3D printed barium titanate/calcium silicate composite biological scaffold combined with structural and material properties

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 158, P. 213783 - 213783

Published: Jan. 26, 2024

Language: Английский

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3D Printing and Biomedical Applications of Piezoelectric Composites: A Critical Review

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Abstract Piezoelectric composites have received widespread attentions in the fields of biomedicine and vitro wearable devices due to their ability convert mechanical forces into charge signals. The preparation piezoelectric with complex structures through 3D printing technology can not only effectively improve output, but also enable customized therapeutic applications. This paper first introduces types reviews commonly used preparation, analyzing advantages disadvantages each technology. Then, state‐of‐the‐art biomedical applications composites, including drug sustained‐release, wound healing promotion, bone tissue cells growth promoting, neurorehabilitation stimulating, ultrasonic diagnosis, vivo biosensing sensing, are emphasized. Finally, main factors affecting printed outlooked, an in‐depth discussion on challenges toward analyzed. review is believed provide some fundamental knowledge composites.

Language: Английский

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Piezoelectric Biomaterial with Advanced Design for Tissue Infection Repair

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract Bacterial infection has become the most dangerous factor in tissue repair, which strongly affects regeneration efficiency and wellness of patients. Piezoelectric materials exhibit outstanding advantage producing electrons without external power supply. The ability electron enrichment reactive oxygen species generation through noninvasive stimulations enables piezoelectric potential applications antibacterial. Many studies have proved feasibility as a functional addition antibacterial biomaterial. In fact, numerous with ingenious designs are reported to be effective processes. This review summarizes mechanisms piezoelectric, illuminating their combating bacteria. Recent advancement design construction biomaterial including defect engineering, heterojunction, synergy metal composite scaffold configuration thoroughly reviewed. Moreover, therapeutic effects common tissues requirements introduced, such orthopedics, dental, wound healing. Finally, development prospects points deserving further exploration listed. is expected provide valuable insight into relationship between processes materials, inspiring constructive this emerging scientific discipline.

Language: Английский

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Elastic and failure characterization of hydroxyapatite TPMS scaffolds using a combined approach of ultrasound, compression tests and micro-CT based numerical models

Acta Materialia, Journal Year: 2025, Volume and Issue: 287, P. 120776 - 120776

Published: Jan. 31, 2025

Language: Английский

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Three‐Dimensional Printing Applications for Bone Tissue Engineering: A Review

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)

Published: March 31, 2025

ABSTRACT 3D printing technology has shown significant promise in bone tissue engineering, enabling the fabrication of intricate structures while controlling porosity and mechanical properties. Integrating into provides a vital benefit by allowing implants to precisely match an individual's anatomy, improving outcomes reducing risk rejection. Additionally, this approach supports inclusion bioactive substances growth factors enhance regeneration. This study examines most recent advances for production, stressing their potential regenerative medicine personalized healthcare. It also addresses challenges associated with current processes engineering explores possible avenues future research development. Furthermore, article investigates how biocompatibility bioactivity materials used facilitate effective Likewise, it evaluates scaffold design architecture can promote cell attachment, proliferation, differentiation, thereby encouraging successful restoration. In conclusion, thorough assessment offers critical insights progress obstacles proposes directions inquiry exciting field. By leveraging these advancements, clinicians researchers pioneer new therapies that address defects improve outcomes.

Language: Английский

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Enhanced osteogenic and ROS-scavenging MXene nanosheets incorporated gelatin-based nanocomposite hydrogels for critical-sized calvarial defect repair

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 131914 - 131914

Published: May 3, 2024

Language: Английский

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Micro-arranged ZnO particles and conductive fillers in PCL composites for enhanced piezoelectric and dielectric properties in bone tissue engineering applications

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113672 - 113672

Published: Jan. 1, 2025

Language: Английский

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