Biomedical Technology, Год журнала: 2024, Номер 9, С. 100068 - 100068
Опубликована: Дек. 25, 2024
Язык: Английский
Journal of environmental chemical engineering, Год журнала: 2024, Номер 12(4), С. 113208 - 113208
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
16
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 172, С. 116238 - 116238
Опубликована: Фев. 3, 2024
Intervertebral disc degeneration (IDD) is a disease that severely affects spinal health and prevalent worldwide. Mesenchymal stem cells (MSCs) their derived extracellular vesicles (EVs) have regenerative potential emerged as promising therapeutic tools for treating degenerative discs. However, challenges such the harsh microenvironment of degenerated intervertebral discs EVs' limited stability efficacy hindered clinical application. In recent years, hydrogels attracted much attention in field IDD therapy because they can mimic physiologic provide solution by providing suitable growth environment MSCs EVs. This review introduced biological properties EVs, summarized research on application EVs IDD, current trial studies also explored mechanism action addition, plenty elaborated different classified tissue engineering, synergistic effect promoting regeneration, wide IDD. Finally, problems still faced hydrogel-loaded treatment are summarized, solutions proposed. paper outlines effects combination with aims to theoretical references future related studies.
Язык: Английский
Процитировано
11
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 266, С. 131337 - 131337
Опубликована: Апрель 2, 2024
Язык: Английский
Процитировано
10
Polymers, Год журнала: 2024, Номер 16(2), С. 281 - 281
Опубликована: Янв. 19, 2024
Infected bone defects represent a common clinical condition involving tissue, often necessitating surgical intervention and antibiotic therapy. However, conventional treatment methods face obstacles such as resistance susceptibility to postoperative infections. Hydrogels show great potential for application in the field of tissue engineering due their advantageous biocompatibility, unique mechanical properties, exceptional processability, degradability. Recent interest has surged employing hydrogels novel therapeutic infected repair. This article aims comprehensively review existing literature on anti-microbial osteogenic approaches utilized by repairing bones, encompassing fabrication techniques, antimicrobial efficacy, biological activities. Additionally, opportunities practical implementation will be explored. Lastly, limitations presently encountered prospective avenues further investigation realm hydrogel materials management deliberated. provides theoretical foundation advanced design strategies defects.
Язык: Английский
Процитировано
9
Science China Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
1
Progress in Materials Science, Год журнала: 2025, Номер 151, С. 101428 - 101428
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162191 - 162191
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)
Опубликована: Апрель 22, 2024
Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli-responsive hydrogels have great potential treatment IDD by facilitating localized controlled drug delivery. Herein, an injectable drug-loaded dual stimuli-responsive adhesive hydrogel for microenvironmental regulation IDD, is developed. The gelatin methacryloyl functionalized with phenylboronic acid groups to enhance loading capacity enable behavior, while incorporation oxidized hyaluronic further improves properties. prepared exhibits enhanced diol-containing drugs, pH- reactive oxygen species (ROS)-responsive behaviors, excellent radical scavenging efficiency, potent antibacterial activity, favorable biocompatibility. Furthermore, shows a beneficial protective efficacy on NP cells within vitro oxidative stress microenvironment. vivo results demonstrate hydrogel's therapeutic effect treating maintaining water retention, restoring height, promoting regeneration, indicating that this holds as promising approach regulating microenvironment alleviating progression IDD.
Язык: Английский
Процитировано
7
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Янв. 30, 2024
Chronic low back pain (LBP) is an increasingly prevalent issue, especially among aging populations. A major underlying cause of LBP intervertebral disc degeneration (IDD), often triggered by (IVD) inflammation. Inflammation the IVD divided into Septic and Aseptic Conservative therapy surgical treatment fail to address root IDD. Recent advances in infection inflammation range from antibiotics small-molecule drugs cellular therapies, biological agents, innovative biomaterials. This review sheds light on complex mechanisms physiological biochemical processes Furthermore, it provides overview recent research developments this area, intending identify novel therapeutic targets guide future clinical strategies for effectively treating IVD-related conditions.
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134609 - 134609
Опубликована: Авг. 11, 2024
Язык: Английский
Процитировано
4