Biomedical Technology, Journal Year: 2024, Volume and Issue: 9, P. 100068 - 100068
Published: Dec. 25, 2024
Language: Английский
Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(4), P. 113208 - 113208
Published: June 1, 2024
Language: Английский
Citations
16
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 172, P. 116238 - 116238
Published: Feb. 3, 2024
Intervertebral disc degeneration (IDD) is a disease that severely affects spinal health and prevalent worldwide. Mesenchymal stem cells (MSCs) their derived extracellular vesicles (EVs) have regenerative potential emerged as promising therapeutic tools for treating degenerative discs. However, challenges such the harsh microenvironment of degenerated intervertebral discs EVs' limited stability efficacy hindered clinical application. In recent years, hydrogels attracted much attention in field IDD therapy because they can mimic physiologic provide solution by providing suitable growth environment MSCs EVs. This review introduced biological properties EVs, summarized research on application EVs IDD, current trial studies also explored mechanism action addition, plenty elaborated different classified tissue engineering, synergistic effect promoting regeneration, wide IDD. Finally, problems still faced hydrogel-loaded treatment are summarized, solutions proposed. paper outlines effects combination with aims to theoretical references future related studies.
Language: Английский
Citations
11
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131337 - 131337
Published: April 2, 2024
Language: Английский
Citations
10
Polymers, Journal Year: 2024, Volume and Issue: 16(2), P. 281 - 281
Published: Jan. 19, 2024
Infected bone defects represent a common clinical condition involving tissue, often necessitating surgical intervention and antibiotic therapy. However, conventional treatment methods face obstacles such as resistance susceptibility to postoperative infections. Hydrogels show great potential for application in the field of tissue engineering due their advantageous biocompatibility, unique mechanical properties, exceptional processability, degradability. Recent interest has surged employing hydrogels novel therapeutic infected repair. This article aims comprehensively review existing literature on anti-microbial osteogenic approaches utilized by repairing bones, encompassing fabrication techniques, antimicrobial efficacy, biological activities. Additionally, opportunities practical implementation will be explored. Lastly, limitations presently encountered prospective avenues further investigation realm hydrogel materials management deliberated. provides theoretical foundation advanced design strategies defects.
Language: Английский
Citations
9
Science China Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Language: Английский
Citations
1
Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101428 - 101428
Published: Jan. 9, 2025
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162191 - 162191
Published: March 1, 2025
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)
Published: April 22, 2024
Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli-responsive hydrogels have great potential treatment IDD by facilitating localized controlled drug delivery. Herein, an injectable drug-loaded dual stimuli-responsive adhesive hydrogel for microenvironmental regulation IDD, is developed. The gelatin methacryloyl functionalized with phenylboronic acid groups to enhance loading capacity enable behavior, while incorporation oxidized hyaluronic further improves properties. prepared exhibits enhanced diol-containing drugs, pH- reactive oxygen species (ROS)-responsive behaviors, excellent radical scavenging efficiency, potent antibacterial activity, favorable biocompatibility. Furthermore, shows a beneficial protective efficacy on NP cells within vitro oxidative stress microenvironment. vivo results demonstrate hydrogel's therapeutic effect treating maintaining water retention, restoring height, promoting regeneration, indicating that this holds as promising approach regulating microenvironment alleviating progression IDD.
Language: Английский
Citations
7
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 30, 2024
Chronic low back pain (LBP) is an increasingly prevalent issue, especially among aging populations. A major underlying cause of LBP intervertebral disc degeneration (IDD), often triggered by (IVD) inflammation. Inflammation the IVD divided into Septic and Aseptic Conservative therapy surgical treatment fail to address root IDD. Recent advances in infection inflammation range from antibiotics small-molecule drugs cellular therapies, biological agents, innovative biomaterials. This review sheds light on complex mechanisms physiological biochemical processes Furthermore, it provides overview recent research developments this area, intending identify novel therapeutic targets guide future clinical strategies for effectively treating IVD-related conditions.
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134609 - 134609
Published: Aug. 11, 2024
Language: Английский
Citations
4