Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15962 - 15977

Опубликована: Авг. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Язык: Английский

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Sulfur-regulated defect engineering for enhanced ultrasonic piezocatalytic therapy of bacteria-infected bone defects

Chemical Engineering Journal, Год журнала: 2022, Номер 435, С. 134624 - 134624

Опубликована: Янв. 11, 2022

Язык: Английский

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Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 7326 - 7378

Опубликована: Март 13, 2023

Cancer thermal therapy, also known as hyperthermia has long been exploited to eradicate mass lesions that are now defined cancer. With the development of corresponding technologies and equipment, local therapies such radiofrequency ablation, microwave high-intensity focused ultrasound, have validated effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages adjacent normal tissues incomplete ablation particularly for large tumors, restricting their wide usage. Attributed versatile physiochemical properties, biomaterials specially designed potentiate treatments according unique working principles. Meanwhile, biomaterial-based delivery systems able bridge with other types treatment strategies chemotherapy, radiotherapy immunotherapy. Therefore, this review, we discuss recent progress functional reinforce by functioning sensitizers endow more efficient tumor-localized and/or vehicles synergize therapeutic modalities combined cancer treatments. Thereafter, provide a critical perspective on further biomaterial-assisted toward applications.

Язык: Английский

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An Intelligent Cell-Derived Nanorobot Bridges Synergistic Crosstalk Between Sonodynamic Therapy and Cuproptosis to Promote Cancer Treatment

Nano Letters, Год журнала: 2023, Номер 23(7), С. 3038 - 3047

Опубликована: Март 23, 2023

Recent progress in cuproptosis sheds light on the development of treatment approaches for advancing sonodynamic therapy (SDT) due to its unique cell death mechanism. Herein, we elaborately developed an intelligent cell-derived nanorobot (SonoCu), composed macrophage-membrane-camouflaged nanocarrier encapsulating copper-doped zeolitic imidazolate framework-8 (ZIF-8), perfluorocarbon, and sonosensitizer Ce6, synergistically triggering cuproptosis-augmented SDT. SonoCu not only improved tumor accumulation cancer-cell uptake through cell-membrane camouflaging but responded ultrasound stimuli enhance intratumor blood flow oxygen supply, which consequently overcame barriers activated cuproptosis. Importantly, SDT effectiveness could be further amplified by multiple mechanisms, including reactive species accumulation, proteotoxic stress, metabolic regulation, sensitized cancer death. Particularly, exhibited ultrasound-responsive cytotoxicity against cells healthy cells, endowing it with good biosafety. Therefore, present first anticancer combination cuproptosis, may inspire studies pursuing a rational multimodal strategy.

Язык: Английский

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Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet‐Based Sonosensitizers Via Crystalline‐to‐Amorphous Phase Transformation

Advanced Materials, Год журнала: 2023, Номер 35(17)

Опубликована: Фев. 13, 2023

Abstract Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other strategies. However, the current sonosensitizers used SDT normally exhibit low activity ultrasound (US)‐induced reactive oxygen species (ROS) generation. Herein, crystalline‐to‐amorphous phase transformation is reported as simple but powerful strategy to engineer ultrathin 2D CoW‐LDH and NiW‐LDH nanosheets highly efficient SDT. The from polycrystalline amorphous ones achieved through acid etching treatment. Importantly, one, (a‐CoW‐LDH) possess higher ROS generation under US irradiation, which ≈17 times commercial TiO 2 sonosensitizer. results suggest that enhanced performance a‐CoW‐LDH US‐induced may be attributed transformation‐induced defect electronic structure changes. After polyethylene glycol modification, can serve high‐efficiency sonosensitizer achieve cell death in vitro tumor eradication vivo irradiation.

Язык: Английский

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Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives

Military Medical Research, Год журнала: 2022, Номер 9(1)

Опубликована: Июнь 9, 2022

Abstract Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor, and it associated with poor prognosis. Its characteristics of being highly invasive undergoing heterogeneous genetic mutation, as well presence blood–brain barrier (BBB), have reduced efficacy GBM treatment. The emergence a novel therapeutic method, namely, sonodynamic therapy (SDT), provides promising strategy for eradicating tumors via activated sonosensitizers coupled low-intensity ultrasound. SDT can provide tumor killing effects deep-seated tumors, such tumors. However, conventional cannot effectively reach region kill additional cells, especially cells. Efforts should be made to develop method help agents pass through BBB accumulate in With development multifunctional nanosensitizers newly emerging combination strategies, ability selectivity greatly improved are accompanied fewer side effects. In this review, we systematically summarize findings previous studies on GBM, focus recent developments directions future research.

Язык: Английский

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Cancer cell membrane-coated C-TiO2 hollow nanoshells for combined sonodynamic and hypoxia-activated chemotherapy

Acta Biomaterialia, Год журнала: 2022, Номер 152, С. 562 - 574

Опубликована: Сен. 5, 2022

Язык: Английский

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Liquid exfoliation of ultrasmall zirconium carbide nanodots as a noninflammatory photothermal agent in the treatment of glioma

Biomaterials, Год журнала: 2022, Номер 292, С. 121917 - 121917

Опубликована: Ноя. 24, 2022

Язык: Английский

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Facile synthesis of 2D Al-TCPP MOF nanosheets for efficient sonodynamic cancer therapy

Materials Chemistry Frontiers, Год журнала: 2023, Номер 7(8), С. 1684 - 1693

Опубликована: Янв. 1, 2023

2D Al-TCPP MOF nanosheets were prepared via a simple solvothermal synthesis method without the need for any surfactants and found to be an effective sonosensitizer sonodynamic cancer therapy.

Язык: Английский

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Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100559 - 100559

Опубликована: Янв. 21, 2023

With the widespread prevalence of drug-resistant pathogens, traditional antibiotics have limited effectiveness and do not yield desired outcomes. Recently, alternative antibacterial therapies based on ultrasound (US) been explored to overcome crisis bacterial pathogens. Antimicrobial sonodynamic therapy (aSDT) offers an excellent solution that relies US irradiation produce reactive oxygen species (ROS) achieve antibiotic-free mediated antimicrobial effects. In addition, aSDT possesses advantage superior tissue penetrability compared light irradiation, demonstrating great feasibility in treating deep infections. Although existing conventional sonosensitizers can ROS for activity, some limitations, such as low penetration rate, nonspecific distribution poor production under hypoxic conditions, result suboptimal sterilization aSDT. emerging nanosonosensitizers enormous advantages high-performance agents aSDT, which deficiencies described above. Thus, nanosonosensitizer-mediated has a bright future management This review classifies current available provides overview mechanisms, biomedical applications, recent advances perspectives

Язык: Английский

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