Abstract
Nano‐immunotherapy
has
been
recognized
as
a
highly
promising
strategy
for
cancer
treatment
in
recent
decades,
which
combines
nanotechnology
and
immunotherapy
to
combat
against
tumors.
Hybrid
nanomaterials
consisting
of
at
least
two
constituents
with
distinct
compositions
properties,
usually
organic
inorganic,
have
engineered
integrated
functions
enormous
potential
boosting
immunotherapy.
This
review
provides
summary
hybrid
reported
immunotherapy,
including
nanoscale
metal–organic
frameworks,
metal–phenolic
networks,
mesoporous
organosilica
nanoparticles,
metallofullerene
nanomaterials,
polymer–lipid,
biomacromolecule‐based
nanomaterials.
The
combination
chemotherapy,
chemodynamic
therapy,
radiotherapy,
radiodynamic
photothermal
photodynamic
sonodynamic
therapy
based
on
is
also
discussed.
Finally,
the
current
challenges
prospects
designing
their
application
are
outlined.
Advanced Materials,
Год журнала:
2022,
Номер
35(19)
Опубликована: Сен. 19, 2022
Abstract
As
an
essential
micronutrient,
manganese
(Mn)
participates
in
various
physiological
processes
and
plays
important
roles
host
immune
system,
hematopoiesis,
endocrine
function,
oxidative
stress
regulation.
Mn‐based
nanoparticles
are
considered
to
be
biocompatible
show
versatile
applications
nanomedicine,
particular
utilized
tumor
immunotherapy
the
following
ways:
1)
acting
as
a
nanocarrier
deliver
immunotherapeutic
agents
for
immunotherapy;
2)
serving
adjuvant
regulate
microenvironment
enhance
3)
activating
host's
system
through
cGAS‐STING
pathway
trigger
4)
real‐time
monitoring
effect
by
magnetic
resonance
imaging
(MRI)
since
Mn
2+
ions
ideal
MRI
contrast
agent
which
can
significantly
T
1
‐weighted
signal
after
binding
proteins.
This
comprehensive
review
focuses
on
most
recent
progress
of
nanoplatforms
immunotherapy.
The
characteristics
first
discussed
guide
design
multifunctional
nanoplatforms.
Then
biomedical
nanoplatforms,
including
alone,
immunotherapy‐involved
multimodal
synergistic
therapy,
imaging‐guided
detail.
Finally,
challenges
future
developments
highlighted.
Cancer
immunotherapy
effect
can
be
greatly
enhanced
by
other
methods
to
induce
immunogenic
cell
death
(ICD),
which
has
profoundly
affected
as
a
highly
efficient
paradigm.
However,
these
treatments
have
significant
limitations,
either
causing
damage
of
the
immune
system
or
limited
superficial
tumors.
Sonodynamic
therapy
(SDT)
ICD
promote
without
affecting
because
its
excellent
spatiotemporal
selectivity
and
low
side
effects.
Nevertheless,
SDT
is
still
reactive
oxygen
species
yield
complex
tumor
microenvironment.
Recently,
some
emerging
SDT-based
nanomedicines
made
numerous
attractive
encouraging
achievements
in
field
cancer
due
high
immunotherapeutic
efficiency.
this
cross-cutting
research
far
from
being
widely
explored
huge
professional
barriers.
Herein,
characteristics
microenvironment
mechanisms
are
firstly
systematically
summarized.
Subsequently,
therapeutic
mechanism
fully
summarized,
advantages
limitations
discussed.
The
representative
advances
for
further
highlighted.
Finally,
application
prospects
challenges
future
clinical
translation
Advanced Materials,
Год журнала:
2023,
Номер
35(33)
Опубликована: Март 7, 2023
Abstract
Immunotherapy
has
made
remarkable
strides
in
cancer
therapy
over
the
past
decade.
However,
such
emerging
still
suffers
from
low
response
rates
and
immune‐related
adverse
events.
Various
strategies
have
been
developed
to
overcome
these
serious
challenges.
Therein,
sonodynamic
(SDT),
as
a
non‐invasive
treatment,
received
ever‐increasing
attention
especially
treatment
of
deep‐seated
tumors.
Significantly,
SDT
can
effectively
induce
immunogenic
cell
death
trigger
systemic
anti‐tumor
immune
response,
termed
immunotherapy.
The
rapid
development
nanotechnology
revolutionized
effects
with
robust
induction.
As
result,
more
innovative
nanosonosensitizers
synergistic
modalities
are
established
superior
efficacy
safe
profile.
In
this
review,
recent
advances
immunotherapy
summarized
particular
emphasis
on
how
be
explored
harness
for
amplifying
response.
Moreover,
current
challenges
field
prospects
its
clinical
translation
also
presented.
It
is
anticipated
that
review
provide
rational
guidance
facilitate
nanomaterials‐assisted
immunotherapy,
helping
pave
way
next‐generation
eventually
achieve
durable
patients.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(6), С. 2031 - 2081
Опубликована: Янв. 1, 2023
Bioactive
materials
are
a
special
class
of
biomaterials
that
can
react
in
vivo
to
induce
biological
response
or
regulate
functions,
thus
achieving
better
curative
effect
than
traditional
inert
biomaterials.
For
cancer
theranostics,
compared
with
organic
polymer
nanomaterials,
inorganic
nanomaterials
possess
unique
physical
and
chemical
properties,
have
stronger
mechanical
stability
on
the
basis
maintaining
certain
bioactivity,
easy
be
compounded
various
carriers
(polymer
carriers,
etc.),
so
as
achieve
specific
antitumor
efficacy.
After
entering
nanoscale,
due
nano-size
effect,
high
surface
area
nanostructures,
exhibit
effects,
which
significantly
influence
interaction
organisms.
Therefore,
research
applications
bioactive
theranostics
attracted
wide
attention.
In
this
review,
we
mainly
summarize
recent
progress
also
introduce
definition,
synthesis
modification
strategies
nanomaterials.
Thereafter,
tumor
imaging
therapy,
including
microenvironment
(TME)
regulation,
catalytic
gas
regulatory
cell
death
immunotherapy,
discussed.
Finally,
biosafety
challenges
mentioned,
their
future
development
opportunities
prospected.
This
review
highlights
bioapplication
ACS Nano,
Год журнала:
2023,
Номер
17(5), С. 4495 - 4506
Опубликована: Фев. 27, 2023
Radiotherapy
(RT),
as
one
of
the
main
methods
in
clinical
treatment
various
malignant
tumors,
would
induce
systemic
immunotherapeutic
effects
by
triggering
immunogenic
cell
death
(ICD)
cancer
cells.
However,
antitumor
immune
responses
produced
RT-induced
ICD
alone
usually
are
not
robust
enough
to
eliminate
distant
tumors
and
thus
ineffective
against
metastases.
Herein,
a
biomimetic
mineralization
method
for
facile
synthesis
MnO2
nanoparticles
with
high
anti-programmed
ligand
1
(αPDL1)
encapsulation
efficiency
(αPDL1@MnO2)
is
proposed
reinforce
responses.
This
therapeutic
nanoplatforms-mediated
RT
can
significantly
improve
killing
tumor
cells
effectively
evoke
overcoming
hypoxia-induced
radio-resistance
reprogramming
immunosuppressive
microenvironment
(TME).
Furthermore,
released
Mn2+
ions
from
αPDL1@MnO2
under
acidic
pH
activate
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
genes
(STING)
pathway
facilitate
dendritic
(DCs)
maturation.
Meanwhile,
αPDL1
further
promote
intratumoral
infiltration
cytotoxic
T
lymphocytes
(CTLs)
trigger
responses,
resulting
strong
abscopal
effect
inhibit
Overall,
biomineralized
MnO2-based
nanoplatforms
offer
simple
strategy
TME
modulation
activation,
which
promising
enhanced
immunotherapy.
ACS Nano,
Год журнала:
2022,
Номер
16(10), С. 16909 - 16923
Опубликована: Окт. 6, 2022
Cancer
immunotherapy
holds
great
promise
but
is
generally
limited
by
insufficient
induction
of
anticancer
immune
responses.
Here,
a
metal
micellar
nanovaccine
developed
the
self-assembly
manganese
(Mn),
stimulator
interferon
genes
(STING)
agonist
(ABZI)
and
naphthalocyanine
(ONc)
coordinated
nanoparticles
(ONc-Mn-A)
in
maleimide-modified
Pluronic
F127
(malF127)
micelles.
Owing
to
synergy
between
Mn
ABZI,
nanovaccine,
termed
ONc-Mn-A-malF127,
elevates
levels
interferon-β
(IFNβ)
324-
8-fold
vivo,
compared
use
or
ABZI
alone.
As
such,
activation
cyclic
guanosine
monophosphate-adenosine
monophosphate
synthase
(cGAS)-STING
pathway
induces
sufficient
dendritic
cell
(DC)
maturation,
eventually
resulting
death
CD8+
T
cell-sensitive
tumors
cell-resistant
simultaneously
promoting
cytotoxic
cells
NK
cells,
respectively.
Furthermore,
with
ONc
used
as
chelator
an
efficient
photosensitizer,
photoinduced
immunogenic
(ICD)
tumor
releases
damage-associated
molecular
patterns
(DAMPs)
neoantigens
from
dying
primary
upon
laser
irradiation,
which
are
captured
situ
malF127
then
transported
DCs.
After
treatment,
addition
photothermal
therapy,
responses
characterized
level
IFNβ
further
elevated
another
4-fold.
In
murine
cancer
models,
ICD-based
metalloimmunotherapy
using
ONc-Mn-A-malF127
single
dose
intravenous
injection
achieved
eradication
distant
tumors.
Taken
together,
offers
nanoplatform
enhance
efficacy
ICD
based
strong
abscopal
effect.
Advanced Materials,
Год журнала:
2023,
Номер
35(51)
Опубликована: Июнь 1, 2023
Sonodynamic
therapy
(SDT)
is
a
promising
non-invasive
therapeutic
modality
to
treat
deep-seated
tumors
owing
the
good
tissue
penetration
ability
and
spatiotemporal
controllability
of
ultrasound
(US);
however,
low
sonodynamic
activity
potential
side
effects
greatly
limit
its
clinical
translation.
Cancer
immunotherapy
that
leverages
immune
system
fight
against
cancer
has
great
synergize
with
SDT
for
treatment
high
efficiency
safety.
In
this
review,
convergence
exert
their
merits
break
through
limitations
combination
sono-immunotherapy
are
discussed.
The
focus
on
development
construction
organic
materials
immunotherapeutic
efficiency.
These
not
only
induce
immunogenic
cell
death
improve
tumor
immunogenicity
via
but
also
activate
antitumor
immunity
immuno-oncology
drug-mediated
pathway
modulation.
various
drugs
sonosensitizers
categorized
discussed
along
prospects
challenges
