Manganese‐Based Tumor Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(19)

Published: Sept. 19, 2022

Abstract As an essential micronutrient, manganese (Mn) participates in various physiological processes and plays important roles host immune system, hematopoiesis, endocrine function, oxidative stress regulation. Mn‐based nanoparticles are considered to be biocompatible show versatile applications nanomedicine, particular utilized tumor immunotherapy the following ways: 1) acting as a nanocarrier deliver immunotherapeutic agents for immunotherapy; 2) serving adjuvant regulate microenvironment enhance 3) activating host's system through cGAS‐STING pathway trigger 4) real‐time monitoring effect by magnetic resonance imaging (MRI) since Mn 2+ ions ideal MRI contrast agent which can significantly T 1 ‐weighted signal after binding proteins. This comprehensive review focuses on most recent progress of nanoplatforms immunotherapy. The characteristics first discussed guide design multifunctional nanoplatforms. Then biomedical nanoplatforms, including alone, immunotherapy‐involved multimodal synergistic therapy, imaging‐guided detail. Finally, challenges future developments highlighted.

Language: Английский

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Emerging Sonodynamic Therapy‐Based Nanomedicines for Cancer Immunotherapy

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 27, 2022

Cancer immunotherapy effect can be greatly enhanced by other methods to induce immunogenic cell death (ICD), which has profoundly affected as a highly efficient paradigm. However, these treatments have significant limitations, either causing damage of the immune system or limited superficial tumors. Sonodynamic therapy (SDT) ICD promote without affecting because its excellent spatiotemporal selectivity and low side effects. Nevertheless, SDT is still reactive oxygen species yield complex tumor microenvironment. Recently, some emerging SDT-based nanomedicines made numerous attractive encouraging achievements in field cancer due high immunotherapeutic efficiency. this cross-cutting research far from being widely explored huge professional barriers. Herein, characteristics microenvironment mechanisms are firstly systematically summarized. Subsequently, therapeutic mechanism fully summarized, advantages limitations discussed. The representative advances for further highlighted. Finally, application prospects challenges future clinical translation

Language: Английский

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Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: March 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Language: Английский

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Bioactive inorganic nanomaterials for cancer theranostics

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081

Published: Jan. 1, 2023

Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication

Language: Английский

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The promising interplay between sonodynamic therapy and nanomedicine

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 189, P. 114495 - 114495

Published: Aug. 17, 2022

Language: Английский

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Reactive oxygen species-powered cancer immunotherapy: Current status and challenges

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 356, P. 623 - 648

Published: March 21, 2023

Language: Английский

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Manganese Coordination Micelles That Activate Stimulator of Interferon Genes and Capture In Situ Tumor Antigens for Cancer Metalloimmunotherapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(10), P. 16909 - 16923

Published: Oct. 6, 2022

Cancer immunotherapy holds great promise but is generally limited by insufficient induction of anticancer immune responses. Here, a metal micellar nanovaccine developed the self-assembly manganese (Mn), stimulator interferon genes (STING) agonist (ABZI) and naphthalocyanine (ONc) coordinated nanoparticles (ONc-Mn-A) in maleimide-modified Pluronic F127 (malF127) micelles. Owing to synergy between Mn ABZI, nanovaccine, termed ONc-Mn-A-malF127, elevates levels interferon-β (IFNβ) 324- 8-fold vivo, compared use or ABZI alone. As such, activation cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-STING pathway induces sufficient dendritic cell (DC) maturation, eventually resulting death CD8+ T cell-sensitive tumors cell-resistant simultaneously promoting cytotoxic cells NK cells, respectively. Furthermore, with ONc used as chelator an efficient photosensitizer, photoinduced immunogenic (ICD) tumor releases damage-associated molecular patterns (DAMPs) neoantigens from dying primary upon laser irradiation, which are captured situ malF127 then transported DCs. After treatment, addition photothermal therapy, responses characterized level IFNβ further elevated another 4-fold. In murine cancer models, ICD-based metalloimmunotherapy using ONc-Mn-A-malF127 single dose intravenous injection achieved eradication distant tumors. Taken together, offers nanoplatform enhance efficacy ICD based strong abscopal effect.

Language: Английский

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Biomineralized MnO₂ Nanoplatforms Mediated Delivery of Immune Checkpoint Inhibitors with STING Pathway Activation to Potentiate Cancer Radio-Immunotherapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 4495 - 4506

Published: Feb. 27, 2023

Radiotherapy (RT), as one of the main methods in clinical treatment various malignant tumors, would induce systemic immunotherapeutic effects by triggering immunogenic cell death (ICD) cancer cells. However, antitumor immune responses produced RT-induced ICD alone usually are not robust enough to eliminate distant tumors and thus ineffective against metastases. Herein, a biomimetic mineralization method for facile synthesis MnO2 nanoparticles with high anti-programmed ligand 1 (αPDL1) encapsulation efficiency (αPDL1@MnO2) is proposed reinforce responses. This therapeutic nanoplatforms-mediated RT can significantly improve killing tumor cells effectively evoke overcoming hypoxia-induced radio-resistance reprogramming immunosuppressive microenvironment (TME). Furthermore, released Mn2+ ions from αPDL1@MnO2 under acidic pH activate cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway facilitate dendritic (DCs) maturation. Meanwhile, αPDL1 further promote intratumoral infiltration cytotoxic T lymphocytes (CTLs) trigger responses, resulting strong abscopal effect inhibit Overall, biomineralized MnO2-based nanoplatforms offer simple strategy TME modulation activation, which promising enhanced immunotherapy.

Language: Английский

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Cancer cell membrane-coated C-TiO2 hollow nanoshells for combined sonodynamic and hypoxia-activated chemotherapy

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 152, P. 562 - 574

Published: Sept. 5, 2022

Language: Английский

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Hybrid Nanomaterials for Cancer Immunotherapy

Advanced Science, Journal Year: 2022, Volume and Issue: 10(6)

Published: Dec. 25, 2022

Abstract Nano‐immunotherapy has been recognized as a highly promising strategy for cancer treatment in recent decades, which combines nanotechnology and immunotherapy to combat against tumors. Hybrid nanomaterials consisting of at least two constituents with distinct compositions properties, usually organic inorganic, have engineered integrated functions enormous potential boosting immunotherapy. This review provides summary hybrid reported immunotherapy, including nanoscale metal–organic frameworks, metal–phenolic networks, mesoporous organosilica nanoparticles, metallofullerene nanomaterials, polymer–lipid, biomacromolecule‐based nanomaterials. The combination chemotherapy, chemodynamic therapy, radiotherapy, radiodynamic photothermal photodynamic sonodynamic therapy based on is also discussed. Finally, the current challenges prospects designing their application are outlined.

Language: Английский

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