Tumor Microenvironment‐Responsive Nanoparticles Amplifying STING Signaling Pathway for Cancer Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 36(6)

Опубликована: Сен. 19, 2023

Abstract Insufficient activation of the stimulator interferon genes (STING) signaling pathway and profoundly immunosuppressive microenvironment largely limits effect cancer immunotherapy. Herein, tumor (TME)‐responsive nanoparticles (PMM NPs) are exploited that simultaneously harness STING Toll‐like receptor 4 (TLR4) to augment via TLR4‐mediated nuclear factor‐kappa B stimulation, leading increased secretion type I interferons (i.e., 4.0‐fold enhancement IFN‐β) pro‐inflammatory cytokines promote a specific T cell immune response. Moreover, PMM NPs relieve immunosuppression TME by decreasing percentage regulatory cells, polarizing M2 macrophages M1 type, thus creating an immune‐supportive unleash cascade adaptive Combined with anti‐PD‐1 antibody, synergistic efficacy is achieved in both inflamed colorectal noninflamed metastatic breast models. rechallenging tumor‐free animals homotypic cells induced complete rejection, indicating generation systemic antitumor memory. These TME‐responsive may open new avenue achieve spatiotemporal orchestration activation, providing promising clinical candidate for next‐generation

Язык: Английский

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Metal‐based smart nanosystems in cancer immunotherapy

Exploration, Год журнала: 2024, Номер 4(6)

Опубликована: Март 22, 2024

Abstract Metals are an emerging topic in cancer immunotherapy that have shown great potential modulating immunity cycle and promoting antitumor by activating the intrinsic immunostimulatory mechanisms which been identified recent years. The main challenge of metal‐assisted lies fact free metals as ion forms easily cleared during circulation, even cause systemic metal toxicity due to off‐target effects. With rapid development nanomedicine, metal‐based smart nanosystems (MSNs) with unique controllable structure become one most promising delivery carriers solve issue, owing their various endogenous/external stimuli‐responsiveness release ions for metalloimmunotherapy. In this review, state‐of‐the‐art research progress metal‐related is comprehensively summarized. First, mainstream MSNs‐assisted will be delineated. immunological effects certain categorization MSNs different characters compositions then provided, followed representative exemplar applications treatment, synergistic combination immunotherapy. Finally, we conclude review a summary remaining challenges associated provide authors' perspective on further advances.

Язык: Английский

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2D Catalytic Nanozyme Enables Cascade Enzyodynamic Effect‐Boosted and Ca²⁺ Overload‐Induced Synergistic Ferroptosis/Apoptosis in Tumor

Advanced Materials, Год журнала: 2024, Номер 36(24)

Опубликована: Март 19, 2024

Abstract The introduction of glucose oxidase, exhibiting characteristics consumption and H 2 O production, represents an emerging antineoplastic therapeutic approach that disrupts nutrient supply promotes efficient generation reactive oxygen species (ROS). However, the instability natural enzymes their low efficacy significantly impede broader application. In this context, 2D Ca Mn 8 16 nanosheets (CMO NSs) designed engineered to serve as a high‐performance nanozyme, enhancing enzyodynamic effect for ferroptosis–apoptosis synergistic tumor therapy, are presented. addition mimicking activities glutathione peroxidase, catalase, CMO NSs exhibit oxidase‐mimicking activities. This feature contributes antitumor performance through cascade catalytic reactions, involving disruption supply, self‐supply , subsequent ROS generation. exogenous 2+ released from NSs, along with endogenous enrichment induced by peroxidase‐ collectively mediate overload, leading apoptosis. Importantly, ferroptosis process is triggered synchronously output consumption. application ultrasound stimulation further enhances efficiency treatment. work underscores crucial role in therapy against tumors.

Язык: Английский

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Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis

Science Advances, Год журнала: 2024, Номер 10(26)

Опубликована: Июнь 28, 2024

Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task mitigating excessive ROS inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)-coated Janus nanomotors (denominated Motor@M2M) targeted treatment UC. SAM provides protective barrier, ensuring that Motor@M2M withstands harsh gastric milieu exhibits controlled release. M2M enhances targeting precision to tissues acts decoy neutralization Catalytic decomposition H

Язык: Английский

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Immunological nanomaterials to combat cancer metastasis

Chemical Society Reviews, Год журнала: 2024, Номер 53(12), С. 6399 - 6444

Опубликована: Янв. 1, 2024

This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.

Язык: Английский

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NADPH Oxidase‐Like Nanozyme for High‐Efficiency Tumor Therapy Through Increasing Glutathione Consumption and Blocking Glutathione Regeneration

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(11)

Опубликована: Янв. 12, 2024

Abstract To counteract the high level of reactive oxygen species (ROS) caused by rapid growth, tumor cells resist oxidative stress accelerating production and regeneration intracellular glutathione (GSH). Numerous studies focus on consumption GSH, but GSH will enhance reduction to stress. Therefore, inhibiting GSH; while, consuming is great significance for breaking redox balance cells. Herein, a simple termed MnO x ‐coated Au (AMO) nanoflower, as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) nanoenzyme, reported efficient therapy. nanoparticles exhibit capability catalyze oxidation NADPH, hindering regeneration; concurrently functioning photothermal agent. During process eliminating releases Mn 2+ that subsequently engages in Fenton‐like reactions, ultimately facilitating implementation chemodynamic therapy (CDT). Overall, this NOX enzyme‐based nanoplatform enhances ROS generation disrupts state equilibrium, inducing apoptosis ferroptosis blocking increasing consumption, thereby achieving collaborative treatments involving (PTT), CDT, catalytic This research contributes NADPH targeted showcases potential nanozymes.

Язык: Английский

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Carrier-free nanoparticles for cancer theranostics with dual-mode magnetic resonance imaging/fluorescence imaging and combination photothermal and chemodynamic therapy

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125285 - 125285

Опубликована: Янв. 1, 2025

Язык: Английский

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Nanomaterials: small particles show huge possibilities for cancer immunotherapy

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Ноя. 16, 2022

Abstract With the economy's globalization and population's aging, cancer has become leading cause of death in most countries. While imposing a considerable burden on society, high morbidity mortality rates have continuously prompted researchers to develop new oncology treatment options. Anti-tumor regimens evolved from early single surgical combined (or not) chemoradiotherapy then current stage tumor immunotherapy. Tumor immunotherapy undoubtedly pulled some patients back death. However, this strategy activating or boosting body's immune system hardly benefits patients. It is limited by low bioavailability, response rate severe side effects. Thankfully, rapid development nanotechnology broken through bottleneck problem anti-tumor Multifunctional nanomaterials can not only kill tumors combining drugs but also be designed enhance immunity thus achieve multi-treatment effect. worth noting that variety nanomaterials, their modifiability, diversity combinations allow them shine antitumor In paper, several nanobiotics commonly used at are discussed, they activate with unique advantages. conclusion, we reviewed recent advances based such as biological cell membrane modification, self-assembly, mesoporous, metal hydrogels, explore directions strategies for

Язык: Английский

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Nanoenabled Intracellular Metal Ion Homeostasis Regulation for Tumor Therapy

Advanced Science, Год журнала: 2023, Номер 11(7)

Опубликована: Дек. 8, 2023

Abstract Endogenous essential metal ions play an important role in many life processes, especially tumor development and immune response. The approval of various metallodrugs for therapy brings more attention to the antitumor effect ions. With deepening understanding regulation mechanisms ion homeostasis vivo, breaking intracellular becomes a new means inhibit proliferation cells activate Diverse nanomedicines with loading small molecular regulators or have been developed disrupt cells, higher safety efficiency than free compounds. This comprehensive review focuses on latest progress regulation‐based including calcium (Ca 2+ ), ferrous (Fe cuprous (Cu + managanese (Mn zinc (Zn ). physiological functions processes are summarized guide design nanomedicines. Then ions‐based some efficient synergistic therapies highlighted. Finally, challenges future developments also discussed, hoping provide reference finding effective therapies.

Язык: Английский

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“Spark” PtMnIr Nanozymes for Electrodynamic‐Boosted Multienzymatic Tumor Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 36(13)

Опубликована: Дек. 18, 2023

Abstract Multienzyme‐mimicking redox nanozymes capable of efficient reactive oxygen species (ROS) generation and cellular homeostasis disruption are highly pursued for cancer therapy. However, it still faces challenges from the complicate tumor microenvironment (TME) high chance metastasis. Herein, well‐dispersed PtMnIr designed with multiple enzymatic activities, including catalase (CAT), oxidase (OXD), superoxide dismutase (SOD), peroxidase (POD), glutathione (GPx), which continuously produce ROS deplete (GSH) concurrently in an “inner catalytic loop” way. With help electrodynamic stimulus, active “spark” (Ir 3+ Mn ) significantly increased, resulting effective cascade Moreover, cyclic can also facilitate ferroptosis apoptosis cells, boosting synergistic Importantly, lung metastasis inhibition is found, confirms immunotherapy by combined effect immunogenic cell death (ICD) 2+ ‐induced guanosine monophosphate (GMP)–adenosine (AMP) synthase (cGAS)–stimulator interferon genes (cGAS–STING) pathway, contributing great potential treatment malignant tumors.

Язык: Английский

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