ACS Nano,
Год журнала:
2024,
Номер
18(33), С. 22153 - 22171
Опубликована: Авг. 9, 2024
cGAS/STING
pathway,
which
is
highly
related
to
tumor
hypoxia,
considered
as
a
potential
target
for
remodeling
the
immunosuppressive
microenvironment
of
solid
tumors.
Metal
ions,
such
Mn2+,
activate
but
their
efficacy
in
cancer
therapy
limited
by
insufficient
effect
on
immunogenic
cell
death
single
ion.
Here,
we
evaluate
association
between
hypoxia
and
inhibition
report
polymetallic-immunotherapy
strategy
based
large
mesoporous
trimetal-based
nanozyme
(AuPdRh)
coordinated
with
Mn2+
(Mn2+@AuPdRh)
signaling
robust
adaptive
antitumor
immunity.
Specifically,
inherent
CAT-like
activity
this
polymetallic
Mn2+@AuPdRh
decomposes
endogenous
H2O2
into
O2
relieve
induced
suppression
signaling.
Moreover,
displays
potent
near-infrared-II
photothermal
strong
POD-mimic
activity;
generated
hyperthermia
•OH
radicals
synergistically
trigger
tumors,
releasing
abundant
dsDNA,
while
delivered
augments
sensitivity
cGAS
dsDNA
activates
cGAS-STING
thereby
triggering
downstream
immunostimulatory
signals
kill
primary
distant
metastatic
Our
study
demonstrates
metal-based
STING-mediated
may
inspire
development
more
effective
strategies
immunotherapy.
Advanced Materials,
Год журнала:
2023,
Номер
36(6)
Опубликована: Сен. 19, 2023
Abstract
Insufficient
activation
of
the
stimulator
interferon
genes
(STING)
signaling
pathway
and
profoundly
immunosuppressive
microenvironment
largely
limits
effect
cancer
immunotherapy.
Herein,
tumor
(TME)‐responsive
nanoparticles
(PMM
NPs)
are
exploited
that
simultaneously
harness
STING
Toll‐like
receptor
4
(TLR4)
to
augment
via
TLR4‐mediated
nuclear
factor‐kappa
B
stimulation,
leading
increased
secretion
type
I
interferons
(i.e.,
4.0‐fold
enhancement
IFN‐β)
pro‐inflammatory
cytokines
promote
a
specific
T
cell
immune
response.
Moreover,
PMM
NPs
relieve
immunosuppression
TME
by
decreasing
percentage
regulatory
cells,
polarizing
M2
macrophages
M1
type,
thus
creating
an
immune‐supportive
unleash
cascade
adaptive
Combined
with
anti‐PD‐1
antibody,
synergistic
efficacy
is
achieved
in
both
inflamed
colorectal
noninflamed
metastatic
breast
models.
rechallenging
tumor‐free
animals
homotypic
cells
induced
complete
rejection,
indicating
generation
systemic
antitumor
memory.
These
TME‐responsive
may
open
new
avenue
achieve
spatiotemporal
orchestration
activation,
providing
promising
clinical
candidate
for
next‐generation
Abstract
Metals
are
an
emerging
topic
in
cancer
immunotherapy
that
have
shown
great
potential
modulating
immunity
cycle
and
promoting
antitumor
by
activating
the
intrinsic
immunostimulatory
mechanisms
which
been
identified
recent
years.
The
main
challenge
of
metal‐assisted
lies
fact
free
metals
as
ion
forms
easily
cleared
during
circulation,
even
cause
systemic
metal
toxicity
due
to
off‐target
effects.
With
rapid
development
nanomedicine,
metal‐based
smart
nanosystems
(MSNs)
with
unique
controllable
structure
become
one
most
promising
delivery
carriers
solve
issue,
owing
their
various
endogenous/external
stimuli‐responsiveness
release
ions
for
metalloimmunotherapy.
In
this
review,
state‐of‐the‐art
research
progress
metal‐related
is
comprehensively
summarized.
First,
mainstream
MSNs‐assisted
will
be
delineated.
immunological
effects
certain
categorization
MSNs
different
characters
compositions
then
provided,
followed
representative
exemplar
applications
treatment,
synergistic
combination
immunotherapy.
Finally,
we
conclude
review
a
summary
remaining
challenges
associated
provide
authors'
perspective
on
further
advances.
Oral
medication
for
ulcerative
colitis
(UC)
is
often
hindered
by
challenges
such
as
inadequate
accumulation,
limited
penetration
of
mucus
barriers,
and
the
intricate
task
mitigating
excessive
ROS
inflammatory
cytokines.
Here,
we
present
a
strategy
involving
sodium
alginate
microspheres
(SAMs)
incorporating
M2
macrophage
membrane
(M2M)-coated
Janus
nanomotors
(denominated
Motor@M2M)
targeted
treatment
UC.
SAM
provides
protective
barrier,
ensuring
that
Motor@M2M
withstands
harsh
gastric
milieu
exhibits
controlled
release.
M2M
enhances
targeting
precision
to
tissues
acts
decoy
neutralization
Catalytic
decomposition
H
Advanced Materials,
Год журнала:
2024,
Номер
36(24)
Опубликована: Март 19, 2024
Abstract
The
introduction
of
glucose
oxidase,
exhibiting
characteristics
consumption
and
H
2
O
production,
represents
an
emerging
antineoplastic
therapeutic
approach
that
disrupts
nutrient
supply
promotes
efficient
generation
reactive
oxygen
species
(ROS).
However,
the
instability
natural
enzymes
their
low
efficacy
significantly
impede
broader
application.
In
this
context,
2D
Ca
Mn
8
16
nanosheets
(CMO
NSs)
designed
engineered
to
serve
as
a
high‐performance
nanozyme,
enhancing
enzyodynamic
effect
for
ferroptosis–apoptosis
synergistic
tumor
therapy,
are
presented.
addition
mimicking
activities
glutathione
peroxidase,
catalase,
CMO
NSs
exhibit
oxidase‐mimicking
activities.
This
feature
contributes
antitumor
performance
through
cascade
catalytic
reactions,
involving
disruption
supply,
self‐supply
,
subsequent
ROS
generation.
exogenous
2+
released
from
NSs,
along
with
endogenous
enrichment
induced
by
peroxidase‐
collectively
mediate
overload,
leading
apoptosis.
Importantly,
ferroptosis
process
is
triggered
synchronously
output
consumption.
application
ultrasound
stimulation
further
enhances
efficiency
treatment.
work
underscores
crucial
role
in
therapy
against
tumors.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(12), С. 6399 - 6444
Опубликована: Янв. 1, 2024
This
review
highlights
recent
advances
in
immunological
nanomaterials
against
metastasis
and
summarizes
various
nanomaterial-mediated
immunotherapy
strategies.
Medicinal Research Reviews,
Год журнала:
2024,
Номер
44(4), С. 1768 - 1799
Опубликована: Фев. 7, 2024
Adjuvants
are
of
critical
value
in
vaccine
development
as
they
act
on
enhancing
immunogenicity
antigen
and
inducing
long-lasting
immunity.
However,
there
only
a
few
adjuvants
that
have
been
approved
for
clinical
use,
which
highlights
the
need
exploring
developing
new
to
meet
growing
demand
vaccination.
Recently,
emerging
evidence
demonstrates
cGAS-STING
pathway
orchestrates
innate
adaptive
immunity
by
generating
type
I
interferon
responses.
Many
agonists
developed
tested
preclinical
research
treatment
cancer
or
infectious
diseases
with
promising
results.
As
adjuvants,
demonstrated
their
potential
activate
robust
defense
various
diseases,
including
COVID-19
infection.
This
review
summarized
current
developments
field
special
focus
latest
applications
Potential
challenges
were
also
discussed
hope
sparking
future
interests
further
adjuvants.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Metal‐protein
hybrid
materials
represent
a
novel
class
of
functional
that
exhibit
exceptional
physicochemical
properties
and
tunable
structures,
rendering
them
remarkable
applications
in
diverse
fields,
including
engineering,
biocatalysis,
biosensing,
biomedicine.
The
design
development
multifunctional
biocompatible
metal‐protein
have
been
the
subject
extensive
research
key
aspiration
for
practical
clinical
settings.
This
review
provides
comprehensive
analysis
strategies,
intrinsic
properties,
biomedical
these
materials,
with
specific
emphasis
on
their
potential
cancer
therapy,
drug
vaccine
delivery,
antibacterial
treatments,
tissue
regeneration.
Through
rational
design,
stable
can
be
synthesized
using
straightforward
methods,
enabling
therapeutic,
immunomodulatory,
other
desired
functionalities.
Finally,
outlines
existing
limitations
challenges
associated
evaluates
translation,
providing
insights
into
implementation
within
applications.
Biometallic
ions
play
a
crucial
role
in
regulating
the
immune
system.
In
recent
years,
cancer
immunotherapy
has
become
breakthrough
treatment,
achieving
good
efficacy
wide
range
of
cancers
with
its
specificity
and
durability
advantages.
However,
existing
therapies
still
face
challenges,
such
as
tolerance
escape.
(e.g.
zinc,
copper,
magnesium,
manganese,
etc.)
can
assist
enhancing
through
activation
cells,
enhancement
tumor
antigen
presentation,
improvement
microenvironment.
addition,
biometallic
derivatives
directly
inhibit
cell
progression
offer
possibility
effectively
overcoming
limitations
current
by
promoting
responses
reducing
immunosuppressive
signals.
This
review
explores
potential
application
prospects
immunotherapy,
providing
new
ideas
for
future
clinical
metal
part
helping
to
guide
development
more
effective
safe
therapeutic
regimens.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Ноя. 16, 2022
Abstract
With
the
economy's
globalization
and
population's
aging,
cancer
has
become
leading
cause
of
death
in
most
countries.
While
imposing
a
considerable
burden
on
society,
high
morbidity
mortality
rates
have
continuously
prompted
researchers
to
develop
new
oncology
treatment
options.
Anti-tumor
regimens
evolved
from
early
single
surgical
combined
(or
not)
chemoradiotherapy
then
current
stage
tumor
immunotherapy.
Tumor
immunotherapy
undoubtedly
pulled
some
patients
back
death.
However,
this
strategy
activating
or
boosting
body's
immune
system
hardly
benefits
patients.
It
is
limited
by
low
bioavailability,
response
rate
severe
side
effects.
Thankfully,
rapid
development
nanotechnology
broken
through
bottleneck
problem
anti-tumor
Multifunctional
nanomaterials
can
not
only
kill
tumors
combining
drugs
but
also
be
designed
enhance
immunity
thus
achieve
multi-treatment
effect.
worth
noting
that
variety
nanomaterials,
their
modifiability,
diversity
combinations
allow
them
shine
antitumor
In
paper,
several
nanobiotics
commonly
used
at
are
discussed,
they
activate
with
unique
advantages.
conclusion,
we
reviewed
recent
advances
based
such
as
biological
cell
membrane
modification,
self-assembly,
mesoporous,
metal
hydrogels,
explore
directions
strategies
for
