Multifaceted Carbonized Metal–Organic Frameworks Synergize with Immune Checkpoint Inhibitors for Precision and Augmented Cuproptosis Cancer Therapy

ACS Nano, Год журнала: 2024, Номер 18(27), С. 17852 - 17868

Опубликована: Июнь 28, 2024

The discovery of cuproptosis, a copper-dependent mechanism programmed cell death, has provided way for cancer treatment. However, cuproptosis inherent limitations, including potential cellular harm, the lack targeting, and insufficient efficacy as standalone Therefore, exogenously controlled combination treatments have emerged key strategies cuproptosis-based oncotherapy. In this study, Cu2–xSe@cMOF nanoplatform was constructed combined sonodynamic/cuproptosis/gas therapy. This platform enabled precise cotreatment, with external control allowing selective induction in cells. approach effectively prevented metastasis recurrence. Furthermore, antiprogrammed death protein ligand-1 antibody (aPD-L1), maximized advantages immune checkpoint Additionally, under ultrasound irradiation, H2Se gas generated from induced cytotoxicity Further, it reactive oxygen species, which hindered survival proliferation. study reports an externally system that combines carbonized metal–organic framework aPD-L1 to enhance precision reinforced therapy could be valuable effective therapeutic agent reduce mortality morbidity future.

Язык: Английский

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Single Atom Catalysts Remodel Tumor Microenvironment for Augmented Sonodynamic Immunotherapy

Advanced Materials, Год журнала: 2024, Номер 36(25)

Опубликована: Март 16, 2024

The immunosuppressive tumor microenvironment (TME) is a huge hurdle in immunotherapy. Sono-immunotherapy new treatment modality that can reverse TME, but the sonodynamic effects are compromised by overexpressed glutathione (GSH) and hypoxia TME. Herein, this work reports sono-immunotherapy strategy using Pd

Язык: Английский

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Gradient‐Tuned VO₄ Vacancies in BiVO₄ Photoanode for Boosting Bulk Hole Transport and Oxygen Evolution Reaction Performance

Advanced Functional Materials, Год журнала: 2024, Номер 34(30)

Опубликована: Фев. 29, 2024

Abstract Although bismuth vanadate (BiVO 4 ) photoanode has been widely used, the solar‐driven oxygen evolution reaction (OER) performance is constrained due to substantial bulk recombination and poor mobility of charge carriers. Herein, a facile solvothermal post‐treatment approach that employs N,N‐dimethylformamide (DMF) developed induce VO vacancy gradient from surface BiVO film, which not only improves diffusion but also establishes an advantageous upward band promote hole transport. Under Air Mass 1.5 Global (AM1.5G) simulated solar illumination, optimized with (denoted as B(VO) 1‐δ exhibits excellent OER separation efficiency 74.4% at 1.23 V versus reversible hydrogen electrode (RHE) incident‐photon‐to‐current conversion 30.7% 445 nm, 1.2 1.4 times higher than pristine , respectively. After loading nickel‐iron hydroxyl oxide (NiFeOOH) cocatalyst, photocurrent density escalates 5.92 mA cm −2 in scavenger (Na 2 SO 3 solution 5.07 potassium borate buffer RHE, far superior . This work highlights gradient‐tuned vacancies can effectively modulate structure transfer photoanode, providing new strategy for boosting water splitting performance.

Язык: Английский

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An Enzyme‐Engineered Coppery Nanozyme for High‐Efficiency Mild Photothermal/Chemodynamic/Starvation Therapy Through Self‐Reinforcing Cancer Energy Metabolism Regulation

Advanced Functional Materials, Год журнала: 2024, Номер 34(22)

Опубликована: Фев. 5, 2024

Abstract Photothermal therapy (PTT) has a great prospect in further improving tumor therapeutic outcomes, whereas its efficiency is restrained by low light penetration, excessive heat damage to normal tissues, up‐regulated shock proteins (HSPs), and limited effect of single treatment. Herein, an enzyme‐engineered coppery nanozyme based on dendritic mesoporous carbon nanosphere as the cornerstone load with glucose oxidase (GOx) followed modification hyaluronic acid constructed. Density functional theory calculations indicate that obtained exhibits peroxidase glutathione mimicking activities improve hydroxyl radicals (•OH) production. Furthermore, both generation •OH production GOx‐induced energy supply blockade can reduce HSPs expression enhance mild PTT (η = 34.9 %) upon irradiation 1064 nm laser, turn, accelerate catalytic processes for more •OH. Last but not least, introduction copper induce lipoylated protein dihydrolipoamide S‐acetyltransferase aggregation cause cellular cuproptosis. Due synergy multiple therapies, inhibition rate reach 93.4%. Overall, this work provides effective strategy potential treatment basis synergistic therapies.

Язык: Английский

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Single-Atom-Based Nanoenzyme in Tissue Repair

ACS Nano, Год журнала: 2024, Номер 18(20), С. 12639 - 12671

Опубликована: Май 8, 2024

Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.

Язык: Английский

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Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Biomaterials, Год журнала: 2023, Номер 303, С. 122391 - 122391

Опубликована: Ноя. 15, 2023

Язык: Английский

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Piezoelectric Effect Modulates Nanozyme Activity: Underlying Mechanism and Practical Application

Small, Год журнала: 2023, Номер 19(52)

Опубликована: Авг. 27, 2023

Abstract Nanozyme activity relies on surface electron transfer processes. Notably, the piezoelectric effect plays a vital role in influencing nanozyme by generating positive and negative charges materials' surfaces. This article comprehensively reviews potential mechanisms practical applications of regulating through effect. The first elucidates how enables nanozymes to exhibit catalytic activity. It is highlighted that produced this directly participate redox reactions, leading conversion materials from an inactive active state. Moreover, field generated can enhance accelerating rates or reducing binding energy between substrates. Practical are explored subsequent section, including water pollutant degradation, bacterial disinfection, biological detection, tumor therapy, which demonstrate versatile potentials applications. review concludes emphasizing need for further research into nanozymes, suggesting expanding scope types exploring new application areas. Furthermore, promising direction synergistic therapy discussed as inspiring avenue future research.

Язык: Английский

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Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

Small, Год журнала: 2024, Номер 20(44)

Опубликована: Июль 6, 2024

Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.

Язык: Английский

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Steering Piezocatalytic Therapy for Optimized Tumoricidal Effect

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Май 16, 2024

Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.

Язык: Английский

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Язык: Английский

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