Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(25)
Опубликована: Июль 18, 2023
The
healing
of
infected
bone
defects
(IBD)
is
a
complex
physiological
process
involving
series
spatially
and
temporally
overlapping
events,
including
pathogen
clearance,
immunological
modulation,
vascularization,
osteogenesis.
Based
on
the
theory
that
regulated
by
both
biochemical
biophysical
signals,
in
this
study,
copper
doped
bioglass
(CuBGs)/methacryloyl-modified
gelatin
nanoparticle
(MA-GNPs)/methacrylated
silk
fibroin
(SilMA)
hybrid
hydrogel
developed
to
promote
IBD
healing.
This
demonstrates
dual-photocrosslinked
interpenetrating
network
mechanism,
wherein
photocrosslinked
SilMA
as
main
ensures
structural
integrity,
MA-GNPs
colloidal
increases
strength
dissipates
loading
forces.
In
an
model,
exhibits
excellent
characteristics,
such
adhesion,
adaptation
irregular
defect
shapes,
situ
physical
reinforcement.
At
same
time,
sequentially
releasing
bioactive
ions
Cu2+
,
Ca2+
Si2+
from
CuBGs
demand,
spatiotemporally
coordinates
antibacterial,
immunomodulatory
remodeling
efficiently
removing
infection
accelerating
repair
without
use
antibiotics
or
exogenous
recombinant
proteins.
Therefore,
can
be
used
simple
effective
method
for
treatment
IBD.
Advanced Materials,
Год журнала:
2023,
Номер
35(23)
Опубликована: Март 14, 2023
Abstract
Microneedles
provide
an
effective
strategy
for
transdermal
drug
delivery.
Many
endeavors
have
been
devoted
to
developing
smart
microneedles
that
can
respond
and
interact
with
pathophysiological
environments.
Here,
novel
bioinspired
adaptable
indwelling
therapeutic
exosome
encapsulation
are
presented
diabetic
wound
healing
by
a
combined
fabrication
of
template
replication
3D
transfer
printing.
Such
composed
mesenchymal
stem
cell
(MSC)‐exosomes‐encapsulated
adjustable
poly(vinyl
alcohol)
(PVA)
hydrogel
needle
tips
detachable
3M
medical
tape
supporting
substrate.
As
the
mechanical
strength
PVA
is
ionically
responsive
due
Hofmeister
effects,
hardness
resultant
microneedle
be
upregulated
sulfate
ions
ensure
skin
penetration
softened
nitrate
after
tip–substrate
detachment
adapt
surrounding
tissue
release
exosomes.
Because
MSC‐exosomes
effectively
activate
fibroblasts,
vascular
endothelial
cells,
macrophages,
demonstrated
function
promoting
regeneration
in
full‐thickness
cutaneous
wounds
rat
models.
These
features
indicate
practical
values
clinical
prospects
regeneration.
Advanced Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 11, 2023
Bioprinting
has
attracted
much
attention
due
to
its
suitability
for
fabricating
biomedical
devices.
In
particular,
bioprinting
become
one
of
the
growing
centers
in
field
wound
healing,
with
various
types
bioprinted
devices
being
developed,
including
3D
scaffolds,
microneedle
patches,
and
flexible
electronics.
Bioprinted
can
be
designed
specific
biostructures
biofunctions
that
closely
match
shape
sites
accelerate
regeneration
skin
through
approaches.
Herein,
a
comprehensive
review
smart
dressings
is
presented,
emphasizing
crucial
effect
determining
biofunctions.
The
begins
an
overview
techniques
devices,
followed
in-depth
discussion
polymer-based
inks,
modification
strategies,
additive
ingredients,
properties,
applications.
strategies
are
divided
into
seven
categories,
chemical
synthesis
novel
physical
blending,
coaxial
bioprinting,
multimaterial
absorption,
immobilization,
hybridization
living
cells,
examples
presented.
Thereafter,
frontiers
4D
artificial
intelligence-assisted
situ
discussed
from
perspective
interdisciplinary
sciences.
Finally,
current
challenges
future
prospects
this
highlighted.
ACS Nano,
Год журнала:
2023,
Номер
17(21), С. 22106 - 22120
Опубликована: Окт. 30, 2023
Diabetic
wounds
represent
a
persistent
global
health
challenge
with
substantial
impact
on
patients'
and
overall
well-being.
Herein,
hydrogel
system
that
integrates
functionalized
gold
nanorods
(AuNRs)
M2
macrophage-derived
exosomes
(M2-Exos)
was
developed
to
achieve
an
efficient
synergistic
therapy
for
diabetic
wounds.
We
introduced
ion-cross-linked
dissipative
network
into
prefabricated
covalent
cross-linked
(long-chain
polymer
network),
which
prepared
using
AuNRs
as
specific
cross-linker.
The
ion
then
the
long-chain
in
situ
form
structure,
imparting
antiswelling
photothermal
effects
hydrogel.
This
integrated
effectively
scavenged
reactive
oxygen
species
levels,
inhibited
inflammation,
promoted
angiogenesis,
stimulated
antibacterial
activity
through
near-infrared
(NIR)
irradiation.
To
demonstrate
potential
of
hydrogel,
we
established
experimental
animal
models
oral
mucosa
ulceration
full-thickness
skin
defects.
In
vivo
results
confirmed
M2-Exos
released
from
hydrogels
played
crucial
role
wound
closure.
Furthermore,
effect
NIR
eradicated
bacterial
infections
area.
Overall,
our
is
promising
tool
accelerating
chronic
healing
tissue
regeneration.
study
highlights
benefits
combining
bioactive
platform
satisfactory
patients
diabetes.
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 95 - 108
Опубликована: Апрель 23, 2024
Androgenetic
alopecia
(AGA),
the
most
prevalent
clinical
hair
loss,
lacks
safe
and
effective
treatments
due
to
downregulated
angiogenic
genes
insufficient
vascularization
in
perifollicular
microenvironment
of
bald
scalp
AGA
patients.
In
this
study,
a
hyaluronic
acid
(HA)
based
hydrogel-formed
microneedle
(MN)
was
designed,
referred
as
V-R-MNs,
which
simultaneously
loaded
with
vascular
endothelial
growth
factor
(VEGF)
novel
loss
drug
Ritlecitinib,
latter
is
encapsulated
slowly
biodegradable
polyhydroxyalkanoates
(PHAs)
nanoparticles
(R-PHA
NPs)
for
minimally
invasive
treatment.
The
integration
HA
hydrogel
alongside
PHA
significantly
bolstered
mechanical
characteristics
microneedles
enhanced
skin
penetration
efficiency.
Due
biosafety,
strength,
controlled
degradation
properties
formed
microneedles,
V-R-MNs
can
effectively
penetrate
skin's
stratum
corneum,
facilitating
direct
delivery
VEGF
Ritlecitinib
invasive,
painless
long-term
sustained
release
manner.
not
only
promoted
angiogenesis
improve
immune
around
follicle
promote
proliferation
development
cells,
but
also
application
MNs
produce
certain
stimulation
could
angiogenesis.
comparison
minoxidil
treatment,
regeneration
effect
V-R-MN
model
mice
characterized
by
rapid
onset
anagen
phase,
improved
quality,
greater
coverage.
This
introduces
new,
clinically
safer,
more
efficient
strategy
serving
reference
treatment
other
related
diseases.
Abstract
The
healing
process
at
a
wound
is
made
up
of
many
types
cells,
growth
factors,
the
extracellular
matrix,
nerves
and
blood
vessels
all
interacting
with
each
other
in
complex
changing
ways.
Microbial
colonization
proliferation
are
possible
place
injury,
which
makes
infection
more
likely.
Because
this,
any
cut
has
chance
getting
an
infection.
Researchers
have
found
that
infections
make
patients
upset
cost
healthcare
system
lot
money.
Surgical
site
happen
to
people
who
recently
had
surgery.
This
study
shows
such
surgical
linked
high
rate
illness
death.
shown
by
fact
25%
get
serious
sepsis
need
be
transferred
intensive
care
unit.
In
both
animal
models
people,
mesenchymal
stem
cells
(MSCs)
play
active
role
stages
positive
effects.
Exosomes
one
main
things
MSCs
release.
They
effects
similar
those
parent
MSCs.
Various
effector
proteins,
messenger
RNA
microRNAs
can
transported
vesicles
control
activity
target
cells.
big
impact
on
process.
These
results
suggest
using
MSC-exosomes
as
new
type
cell-free
therapy
could
better
safer
option
than
whole
cell
therapy.
review
mostly
about
how
use
parts
help
heal.
Materials Today Bio,
Год журнала:
2024,
Номер
24, С. 100945 - 100945
Опубликована: Янв. 4, 2024
Cell
growth
and
metabolism
require
an
adequate
supply
of
oxygen.
However,
obtaining
sufficient
oxygen
from
the
blood
circulating
around
diabetic
wounds
is
challenging.
Nevertheless,
achieving
a
continuous
stable
required
for
these
to
heal.
Hence,
in
this
study,
we
report
novel
antibacterial
oxygen-producing
silk
fibroin
methacryloyl
hydrogel
microneedle
(MN)
patch
comprising
tips
encapsulated
with
calcium
peroxide
catalase
base
coated
Ag
nanoparticles
(AgNPs).
The
tip
MN
continuously
releases
inhibits
production
reactive
species.
This
accelerates
wound
healing
by
promoting
cellular
accretion
migration,
macrophage
M2
polarization,
angiogenesis.
AgNPs
at
effectively
combat
microbial
infection,
further
facilitating
repair.
These
findings
suggest
that
using
multifunctional
may
be
promising
strategy
clinical
settings.
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 1 - 30
Опубликована: Апрель 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
ACS Sensors,
Год журнала:
2024,
Номер
9(3), С. 1149 - 1161
Опубликована: Март 13, 2024
Interstitial
fluid
(ISF)
has
attracted
extensive
attention
in
an
extremely
wide
range
of
areas
due
to
its
unique
advantages,
such
as
portability,
high
precision,
comfortable
operation,
and
superior
stability.
In
recent
years,
the
microneedle
(MN)
technique
been
considered
be
excellent
tool
for
extracting
ISF
because
it
is
painless
noninvasive.
Recent
reports
have
shown
that
MN
good
application
prospects
extraction.
this
review,
we
provide
comprehensive
in-depth
insight
into
integrated
devices
detection,
covering
basic
structure
well
fabrication
various
applications
Challenges
are
highlighted,
with
a
discussion
on
how
transition
MN-integrated
toward
personalized
healthcare
monitoring
systems.
