ACS Applied Nano Materials,
Год журнала:
2023,
Номер
6(23), С. 21934 - 21944
Опубликована: Ноя. 27, 2023
Bismuth
sulfide
(Bi2S3)
could
respond
to
near-infrared
light
generate
photocurrent,
demonstrating
tremendous
potential
in
constructing
self-powered
electrical
stimulation
accelerate
bone
regeneration.
Nevertheless,
the
facile
recombination
of
electron–hole
pairs
undermined
its
photoelectric
performance.
Herein,
a
sea-buckthorn-like
nanostructured
Bi2S3–BaTiO3
was
synthesized
by
loading
BaTiO3
nanoparticles
onto
Bi2S3
nanorods
through
self-assembly
method
and
then
integrated
into
poly-L-lactic
acid
(PLLA)
powders
fabricate
PLLA/Bi2S3–BaTiO3
scaffolds.
Piezoelectric
would
deform
under
stress
produce
instantaneous
polarization,
which
triggered
positive
negative
charges
presented
on
relative
surfaces
BaTiO3.
Thus,
photogenerated
electrons
holes
be,
respectively,
transferred
charged
BaTiO3,
thereby
achieving
separation.
Results
revealed
that
ultrasonic
irradiation,
photoluminescence
peak
intensity
significantly
reduced
compared
with
Bi2S3,
confirming
improved
pair
Accordingly,
photocurrent
increased
approximately
1.4
times
comparison
Bi2S3.
The
enhanced
effectively
promoted
cell
proliferation
differentiation
upregulating
alkaline
phosphatase
expression,
enhancing
calcium
nodule
deposition,
promoting
cellular
Ca2+
influx.
Consequently,
this
work
provided
perspective
for
establishing
stimulated
scaffold
repair.
Abstract
Nanozymes,
as
innovative
materials,
have
demonstrated
remarkable
potential
in
the
field
of
electrochemical
biosensors.
This
article
provides
an
overview
mechanisms
and
extensive
practical
applications
nanozymes
First,
definition
characteristics
are
introduced,
emphasizing
their
significant
role
constructing
efficient
sensors.
Subsequently,
several
common
categories
nanozyme
materials
delved
into,
including
metal‐based,
carbon‐based,
metal‐organic
framework,
layered
double
hydroxide
nanostructures,
discussing
Regarding
mechanisms,
two
key
roles
particularly
focused
biosensors:
selective
enhancement
signal
amplification,
which
crucially
support
sensor
performance.
In
terms
applications,
widespread
use
nanozyme‐based
biosensors
showcased
various
domains.
From
detecting
biomolecules,
pollutants,
nucleic
acids,
proteins,
to
cells,
providing
robust
means
for
high‐sensitivity
detection.
Furthermore,
insights
into
future
development
is
provided,
encompassing
improvements
optimizations
design
integration,
expansion
application
fields
through
interdisciplinary
collaboration.
conclusion,
this
systematically
presents
biosensors,
offering
valuable
references
prospects
research
field.
Abstract
Nanozyme
activity
relies
on
surface
electron
transfer
processes.
Notably,
the
piezoelectric
effect
plays
a
vital
role
in
influencing
nanozyme
by
generating
positive
and
negative
charges
materials'
surfaces.
This
article
comprehensively
reviews
potential
mechanisms
practical
applications
of
regulating
through
effect.
The
first
elucidates
how
enables
nanozymes
to
exhibit
catalytic
activity.
It
is
highlighted
that
produced
this
directly
participate
redox
reactions,
leading
conversion
materials
from
an
inactive
active
state.
Moreover,
field
generated
can
enhance
accelerating
rates
or
reducing
binding
energy
between
substrates.
Practical
are
explored
subsequent
section,
including
water
pollutant
degradation,
bacterial
disinfection,
biological
detection,
tumor
therapy,
which
demonstrate
versatile
potentials
applications.
review
concludes
emphasizing
need
for
further
research
into
nanozymes,
suggesting
expanding
scope
types
exploring
new
application
areas.
Furthermore,
promising
direction
synergistic
therapy
discussed
as
inspiring
avenue
future
research.
ACS Nano,
Год журнала:
2024,
Номер
18(35), С. 24469 - 24483
Опубликована: Авг. 22, 2024
Bacterial
infections
claim
millions
of
lives
every
year,
with
the
escalating
menace
microbial
antibiotic
resistance
compounding
this
global
crisis.
Nanozymes,
poised
as
prospective
substitutes
for
antibiotics,
present
a
significant
frontier
in
antibacterial
therapy,
yet
their
precise
enzymatic
origins
remain
elusive.
With
continuous
development
nanozymes,
applications
elemental
N-modulated
nanozymes
have
spanned
multiple
fields,
including
sensing
and
detection,
infection
cancer
treatment,
pollutant
degradation.
The
introduction
nitrogen
into
not
only
broadens
application
range
but
also
holds
importance
design
catalysts
biomedical
research.
synergistic
interplay
between
W
N
induces
pivotal
alterations
electronic
configurations,
endowing
tungsten
nitride
(WN)
peroxidase-like
functionality.
Furthermore,
vacancies
augments
nanozyme
activity,
thus
amplifying
catalytic
potential
WN
nanostructures.
Rigorous
theoretical
modeling
empirical
validation
corroborate
genesis
enzyme
activity.
meticulously
engineered
nanoflower
architecture
exhibits
an
exceptional
ability
traversing
bacterial
surfaces,
exerting
potent
bactericidal
effects
through
direct
physical
interactions.
Additionally,
topological
intricacies
these
nanostructures
facilitate
targeting
generated
radicals
on
culminating
efficacy
against
both
Gram-negative
Gram-positive
strains
along
notable
inhibition
biofilm
formation.
Importantly,
assessments
using
skin
model
underscore
proficiency
nanoflowers
effectively
clearing
fostering
wound
healing.
This
pioneering
research
illuminates
realm
pseudoenzyme
activity
capture-killing
strategies,
promising
fertile
ground
innovative,
high-performance
artificial
peroxidases.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(41)
Опубликована: Июль 22, 2024
Abstract
Synthetic
biohybrid
systems
by
coupling
artificial
system
with
nature's
machinery
may
offer
a
disruptive
solution
to
address
the
global
energy
crisis.
We
developed
versatile
electroenzymatic
pathway
for
continuous
synthesis
of
valuable
chemicals,
facilitated
formate‐driven
NADH
regeneration.
Utilizing
bismuth
electrocatalyst,
we
achieved
stable
CO
2
reduction
formate
approximately
90
%
Faraday
efficiency
at
current
density
150
mA
cm
−2
.
The
generated
acts
as
mediator
regenerate
NADH,
which
is
then
coupled
immobilized
redox
enzymes—alcohol
dehydrogenase
(ADH),
L
‐lactate
(LDH),
and
‐glutamate
(GDH)—to
produce
targeted
chemicals
significant
rates
exceptionally
high
turnover
numbers
(1.8×10
6
3.1×10
).
These
achievements
not
only
underscore
but
also
its
practical
applicability
in
industrial
settings.
By
leveraging
situ
formate,
this
innovative
approach
demonstrates
potential
integrating
electrocatalysis
enzymatic
reactions
sustainable
efficient
chemical
production
on
scale.
Heliyon,
Год журнала:
2024,
Номер
10(11), С. e32314 - e32314
Опубликована: Июнь 1, 2024
With
the
rapid
development
of
clinical
diagnosis
and
treatment,
many
traditional
conventional
in
vitro
technologies
are
unable
to
meet
demands
medicine
development.
In
this
situation,
nanomaterials
rapidly
developing
widely
used
field
diagnosis.
Nanomaterials
have
distinct
size-dependent
physical
or
chemical
properties,
their
optical,
magnetic,
electrical,
thermal,
biological
properties
can
be
modulated
at
nanoscale
by
changing
size,
shape,
composition,
surface
functional
groups,
particularly
because
they
a
larger
specific
area
than
macromaterials.
They
provide
an
amount
space
modify
different
molecules
on
surface,
allowing
them
detect
small
substances,
nucleic
acids,
proteins,
microorganisms.
Combining
with
is
expected
result
lower
detection
limits,
higher
sensitivity,
stronger
selectivity.
review,
we
will
discuss
classfication
some
common
nanomaterials,
as
well
applications
protein,
other
aspect
analysis
for
diagnosis,
especially
aging-related
nanodiagnostics.
Finally,
it
summarized
guidelines
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(51), С. 70339 - 70351
Опубликована: Дек. 13, 2024
The
stratum
corneum
of
the
skin
functions
as
a
barrier,
obstructing
drug
absorption
and
complicating
treatment
infections
caused
by
pathogens
such
bacteria,
fungi,
viruses
through
topical
methods.
In
this
research,
microneedle
patch
was
developed,
which
consists
gelatin-sucrose
(SG)
that
encapsulates
polydopamine-copper
nanoparticles
(PDA@Cu)
at
tip
for
antibacterial
purposes.
Poly(ethylene
glycol)
diacrylate
(PEGDA)
served
primary
substrate
shaft
(PDA@Cu-SG/PEGDA).
This
engineered
to
enhance
permeability
facilitate
efficient
delivery
drugs
rapid
dissolution
tips.
Coordinate
bonds
can
be
formed
between
PDA
Cu
ions,
resulting
in
immobilization
particles
on
surface,
aids
green
synthesis
PDA@Cu
photothermal
particles.
SG
polymer,
contained
PDA@Cu,
employed
fill
cavities
series
centrifugation
steps.
Subsequently,
UV-induced
polymerization
carried
out
produce
PEGDA
microneedles
with
hydrophilic
tips
Furthermore,
physicochemical
characteristics
polymer
microneedles,
including
morphology,
composition,
mechanical
strength,
were
thoroughly
characterized.
These
demonstrated
sufficient
strength.
Owing
ability
disrupt
bacterial
membranes,
excellent
vitro
efficacy.
We
validated
activity
against
Escherichia
coli
Staphylococcus
aureus
conducting
plate
coating
assays.
results
assays
indicated
minimally
invasive
strategy
achieved
broad-spectrum
effects;
thus,
may
suitable
approach
managing
polymicrobial
during
clinical
trials.
Chemical & Biomedical Imaging,
Год журнала:
2025,
Номер
3(2), С. 51 - 76
Опубликована: Янв. 21, 2025
Atherosclerosis
(AS)
is
a
serious
disease
that
poses
significant
threat
to
the
global
population.
In
this
review,
we
analyze
development
of
AS
from
multiple
perspectives,
aiming
elucidate
its
molecular
mechanisms.
We
also
focus
on
imaging
techniques
and
therapeutic
approaches,
highlighting
crucial
role
nanomaterials
in
both
therapy
for
AS.
By
leveraging
their
compatibility
targeting
capabilities,
can
be
integrated
with
traditional
medical
agents
achieve
targeted
drug
delivery,
controlled
release,
precise
localization
atherosclerotic
plaques.
