Nanozyme‐Enhanced Electrochemical Biosensors: Mechanisms and Applications

Small, Год журнала: 2023, Номер 20(14)

Опубликована: Ноя. 20, 2023

Abstract Nanozymes, as innovative materials, have demonstrated remarkable potential in the field of electrochemical biosensors. This article provides an overview mechanisms and extensive practical applications nanozymes First, definition characteristics are introduced, emphasizing their significant role constructing efficient sensors. Subsequently, several common categories nanozyme materials delved into, including metal‐based, carbon‐based, metal‐organic framework, layered double hydroxide nanostructures, discussing Regarding mechanisms, two key roles particularly focused biosensors: selective enhancement signal amplification, which crucially support sensor performance. In terms applications, widespread use nanozyme‐based biosensors showcased various domains. From detecting biomolecules, pollutants, nucleic acids, proteins, to cells, providing robust means for high‐sensitivity detection. Furthermore, insights into future development is provided, encompassing improvements optimizations design integration, expansion application fields through interdisciplinary collaboration. conclusion, this systematically presents biosensors, offering valuable references prospects research field.

Язык: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095

Опубликована: Май 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Язык: Английский

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A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Год журнала: 2024, Номер 20(25)

Опубликована: Янв. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Язык: Английский

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Nanozybiotics: Advancing Antimicrobial Strategies Through Biomimetic Mechanisms

Advanced Materials, Год журнала: 2024, Номер 36(33)

Опубликована: Июнь 14, 2024

Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.

Язык: Английский

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Nanozymes regulated by nitrogen element: Mechanism, design, and application

Advanced Powder Materials, Год журнала: 2024, Номер 3(4), С. 100191 - 100191

Опубликована: Март 18, 2024

Nanozymes, a category of nanomaterials endowed with enzyme-mimicking capabilities, have exhibited considerable potential across diverse application domains. This comprehensive review delves into the intricacies regulating nanozymes through N elements, elucidating mechanisms governing element control in design and these nanomaterials. The initial sections introduce foundational background significance nanozymes. Subsequent exploration detailed discussion regulation on nanozymes, encompassing vacancies, doping, coordination, nitride. These regulatory pathways play an instrumental role fine-tuning catalytic activity specificity further scrutinizes practical applications spanning sensing detection, infection therapy, tumor pollutant degradation. In conclusion, it succinctly summarizes current research findings proposes future directions for development. thorough investigation by elements anticipates precise over their performance, thereby advancing extensive utilization realms biomedical environmental applications.

Язык: Английский

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Research progress in the application of MXene in bacterial detection and eradication

Materials Today Physics, Год журнала: 2024, Номер 43, С. 101412 - 101412

Опубликована: Март 26, 2024

Язык: Английский

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Fine‐Tuning Electron Transfer for Nanozyme Design

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 17, 2024

Nanozymes, with their versatile composition and structural adaptability, present distinct advantages over natural enzymes including heightened stability, customizable catalytic activity, cost-effectiveness, simplified synthesis process, making them as promising alternatives in various applications. Recent advancements nanozyme research have shifted focus from serendipitous discovery toward a more systematic approach, leveraging machine learning, theoretical calculations, mechanistic explorations to engineer nanomaterial structures tailored functions. Despite its pivotal role, electron transfer, fundamental process catalysis, has often been overlooked previous reviews. This review comprehensively summarizes recent strategies for modulating transfer processes fine-tune the activity specificity of nanozymes, electron-hole separation carrier transfer. Furthermore, bioapplications these engineered antimicrobial treatments, cancer therapy, biosensing are also introduced. Ultimately, this aims offer invaluable insights design nanozymes enhanced performance, thereby advancing field research.

Язык: Английский

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Nanozymes in environmental remediation: A bibliometric and comprehensive review of their oxidoreductase-mimicking capabilities

Microchemical Journal, Год журнала: 2024, Номер unknown, С. 111748 - 111748

Опубликована: Сен. 1, 2024

Язык: Английский

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Oxygen Vacancy Piezoelectric Nanosheets Constructed by a Photoetching Strategy for Ultrasound “Unlocked” Tumor Synergistic Therapy

Nano Letters, Год журнала: 2024, Номер 24(26), С. 8008 - 8016

Опубликована: Июнь 24, 2024

Piezoelectric dynamic therapy (PzDT) is an effective method of tumor treatment by using piezoelectric polarization to generate reactive oxygen species. In this paper, two-dimensional Cu-doped BiOCl nanosheets with surface vacancies are produced the photoetching strategy. Under ultrasound, a built-in electric field generated promote electron and hole separation. The separated carriers achieve O

Язык: Английский

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Advanced pyro-/piezoelectric catalytic disinfection of water via porous spontaneously polarized ceramic with strong local electric field induced by micro-nano bubbles

Chemical Engineering Journal, Год журнала: 2024, Номер 499, С. 155958 - 155958

Опубликована: Сен. 19, 2024

Язык: Английский

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