International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100286 - 100286
Published: Sept. 17, 2024
Language: Английский
Small, Journal Year: 2023, Volume and Issue: 20(14)
Published: Nov. 20, 2023
Abstract Nanozymes, as innovative materials, have demonstrated remarkable potential in the field of electrochemical biosensors. This article provides an overview mechanisms and extensive practical applications nanozymes First, definition characteristics are introduced, emphasizing their significant role constructing efficient sensors. Subsequently, several common categories nanozyme materials delved into, including metal‐based, carbon‐based, metal‐organic framework, layered double hydroxide nanostructures, discussing Regarding mechanisms, two key roles particularly focused biosensors: selective enhancement signal amplification, which crucially support sensor performance. In terms applications, widespread use nanozyme‐based biosensors showcased various domains. From detecting biomolecules, pollutants, nucleic acids, proteins, to cells, providing robust means for high‐sensitivity detection. Furthermore, insights into future development is provided, encompassing improvements optimizations design integration, expansion application fields through interdisciplinary collaboration. conclusion, this systematically presents biosensors, offering valuable references prospects research field.
Language: Английский
Citations
58
Journal of Cleaner Production, Journal Year: 2023, Volume and Issue: 411, P. 137232 - 137232
Published: April 30, 2023
Language: Английский
Citations
44
Small, Journal Year: 2023, Volume and Issue: 19(52)
Published: Aug. 27, 2023
Abstract Nanozyme activity relies on surface electron transfer processes. Notably, the piezoelectric effect plays a vital role in influencing nanozyme by generating positive and negative charges materials' surfaces. This article comprehensively reviews potential mechanisms practical applications of regulating through effect. The first elucidates how enables nanozymes to exhibit catalytic activity. It is highlighted that produced this directly participate redox reactions, leading conversion materials from an inactive active state. Moreover, field generated can enhance accelerating rates or reducing binding energy between substrates. Practical are explored subsequent section, including water pollutant degradation, bacterial disinfection, biological detection, tumor therapy, which demonstrate versatile potentials applications. review concludes emphasizing need for further research into nanozymes, suggesting expanding scope types exploring new application areas. Furthermore, promising direction synergistic therapy discussed as inspiring avenue future research.
Language: Английский
Citations
27
ACS Nano, Journal Year: 2024, Volume and Issue: 18(35), P. 24469 - 24483
Published: Aug. 22, 2024
Bacterial infections claim millions of lives every year, with the escalating menace microbial antibiotic resistance compounding this global crisis. Nanozymes, poised as prospective substitutes for antibiotics, present a significant frontier in antibacterial therapy, yet their precise enzymatic origins remain elusive. With continuous development nanozymes, applications elemental N-modulated nanozymes have spanned multiple fields, including sensing and detection, infection cancer treatment, pollutant degradation. The introduction nitrogen into not only broadens application range but also holds importance design catalysts biomedical research. synergistic interplay between W N induces pivotal alterations electronic configurations, endowing tungsten nitride (WN) peroxidase-like functionality. Furthermore, vacancies augments nanozyme activity, thus amplifying catalytic potential WN nanostructures. Rigorous theoretical modeling empirical validation corroborate genesis enzyme activity. meticulously engineered nanoflower architecture exhibits an exceptional ability traversing bacterial surfaces, exerting potent bactericidal effects through direct physical interactions. Additionally, topological intricacies these nanostructures facilitate targeting generated radicals on culminating efficacy against both Gram-negative Gram-positive strains along notable inhibition biofilm formation. Importantly, assessments using skin model underscore proficiency nanoflowers effectively clearing fostering wound healing. This pioneering research illuminates realm pseudoenzyme activity capture-killing strategies, promising fertile ground innovative, high-performance artificial peroxidases.
Language: Английский
Citations
12
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(41)
Published: July 22, 2024
Abstract Synthetic biohybrid systems by coupling artificial system with nature's machinery may offer a disruptive solution to address the global energy crisis. We developed versatile electroenzymatic pathway for continuous synthesis of valuable chemicals, facilitated formate‐driven NADH regeneration. Utilizing bismuth electrocatalyst, we achieved stable CO 2 reduction formate approximately 90 % Faraday efficiency at current density 150 mA cm −2 . The generated acts as mediator regenerate NADH, which is then coupled immobilized redox enzymes—alcohol dehydrogenase (ADH), L ‐lactate (LDH), and ‐glutamate (GDH)—to produce targeted chemicals significant rates exceptionally high turnover numbers (1.8×10 6 3.1×10 ). These achievements not only underscore but also its practical applicability in industrial settings. By leveraging situ formate, this innovative approach demonstrates potential integrating electrocatalysis enzymatic reactions sustainable efficient chemical production on scale.
Language: Английский
Citations
8
Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e32314 - e32314
Published: June 1, 2024
With the rapid development of clinical diagnosis and treatment, many traditional conventional in vitro technologies are unable to meet demands medicine development. In this situation, nanomaterials rapidly developing widely used field diagnosis. Nanomaterials have distinct size-dependent physical or chemical properties, their optical, magnetic, electrical, thermal, biological properties can be modulated at nanoscale by changing size, shape, composition, surface functional groups, particularly because they a larger specific area than macromaterials. They provide an amount space modify different molecules on surface, allowing them detect small substances, nucleic acids, proteins, microorganisms. Combining with is expected result lower detection limits, higher sensitivity, stronger selectivity. review, we will discuss classfication some common nanomaterials, as well applications protein, other aspect analysis for diagnosis, especially aging-related nanodiagnostics. Finally, it summarized guidelines
Language: Английский
Citations
6
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 693, P. 137625 - 137625
Published: April 16, 2025
Language: Английский
Citations
0
Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: 3(2), P. 51 - 76
Published: Jan. 21, 2025
Atherosclerosis (AS) is a serious disease that poses significant threat to the global population. In this review, we analyze development of AS from multiple perspectives, aiming elucidate its molecular mechanisms. We also focus on imaging techniques and therapeutic approaches, highlighting crucial role nanomaterials in both therapy for AS. By leveraging their compatibility targeting capabilities, can be integrated with traditional medical agents achieve targeted drug delivery, controlled release, precise localization atherosclerotic plaques.
Language: Английский
Citations
0
ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1777 - 1785
Published: April 8, 2025
Language: Английский
Citations
0