The role of associative fear and avoidance learning in anxiety disorders: Gaps and directions for future research

Neuroscience & Biobehavioral Reviews, Год журнала: 2018, Номер 88, С. 117 - 140

Опубликована: Март 15, 2018

Язык: Английский

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Fear extinction in the human brain: A meta-analysis of fMRI studies in healthy participants

Neuroscience & Biobehavioral Reviews, Год журнала: 2018, Номер 88, С. 16 - 25

Опубликована: Март 11, 2018

Язык: Английский

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More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans - Biological, experiential, temperamental factors, and methodological pitfalls

Neuroscience & Biobehavioral Reviews, Год журнала: 2017, Номер 80, С. 703 - 728

Опубликована: Июль 29, 2017

Язык: Английский

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Understanding clinical fear and anxiety through the lens of human fear conditioning

Nature Reviews Psychology, Год журнала: 2023, Номер 2(4), С. 233 - 245

Опубликована: Фев. 16, 2023

Язык: Английский

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Characterizing cardiac autonomic dynamics of fear learning in humans

Psychophysiology, Год журнала: 2022, Номер 59(12)

Опубликована: Июнь 7, 2022

Understanding transient dynamics of the autonomic nervous system during fear learning remains a critical step to translate basic research into treatment fear-related disorders. In humans, it has been demonstrated that typically elicits heart rate deceleration. However, classical analyses variability (HRV) fail disentangle contribution parasympathetic and sympathetic systems, crucially, they are not able capture phasic changes learning. Here, gain deeper insight physiological underpinnings learning, novel frequency-domain analysis was performed using short-time Fourier transform, instantaneous spectral estimates extracted from point-process modeling algorithm. We tested whether components HRV, used as noninvasive probe mechanisms, can dissociate between conditioned neutral stimuli. found learned elicited deceleration in anticipation noxious Crucially, results revealed significant increase power high frequency band when facing stimulus, indicating increased (vagal) activity, which distinguished stimuli Our findings provide proximal measure involvement cardiac vagal psychophysiology extinction, thus offering new insights for characterization mental health illness.

Язык: Английский

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Neuropharmacological Modulation of N-methyl-D-aspartate, Noradrenaline and Endocannabinoid Receptors in Fear Extinction Learning: Synaptic Transmission and Plasticity

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5926 - 5926

Опубликована: Март 21, 2023

Learning to recognize and respond potential threats is crucial for survival. Pavlovian threat conditioning represents a key paradigm investigating the neurobiological mechanisms of fear learning. In this review, we address role specific neuropharmacological adjuvants that act on neurochemical synaptic transmission, as well brain plasticity processes implicated in memory. We focus novel manipulations targeting glutamatergic, noradrenergic, endocannabinoid systems, how modulation these systems affects extinction learning humans. show administration N-methyl-D-aspartate (NMDA) agonists system by fatty acid amide hydrolase (FAAH) inhibition can boost through stabilization regulation receptor concentration. On other hand, elevated noradrenaline levels dynamically modulate learning, hindering long-term processes. These pharmacological interventions could provide targeted treatments prevention strategies fear-based anxiety-related disorders.

Язык: Английский

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The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 151, С. 105237 - 105237

Опубликована: Май 18, 2023

Язык: Английский

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Activated Tryptophan-Kynurenine metabolic system in the human brain is associated with learned fear

Frontiers in Molecular Neuroscience, Год журнала: 2023, Номер 16

Опубликована: Июль 28, 2023

OPINION article Front. Mol. Neurosci., 28 July 2023Sec. Molecular Signalling and Pathways Volume 16 - 2023 | https://doi.org/10.3389/fnmol.2023.1217090

Язык: Английский

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Targeting Human Glucocorticoid Receptors in Fear Learning: A Multiscale Integrated Approach to Study Functional Connectivity

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 864 - 864

Опубликована: Янв. 10, 2024

Fear extinction is a phenomenon that involves gradual reduction in conditioned fear responses through repeated exposure to fear-inducing cues. Functional brain connectivity assessments, such as functional magnetic resonance imaging (fMRI), provide valuable insights into how regions communicate during these processes. Stress, ubiquitous aspect of life, influences learning and by changing the activity amygdala, prefrontal cortex, hippocampus, leading enhanced and/or impaired extinction. Glucocorticoid receptors (GRs) are key stress response show dual function regulation: while they enhance consolidation memories, also facilitate Accordingly, GR dysregulation associated with anxiety mood disorders. Recent advancements cognitive neuroscience underscore need for comprehensive understanding integrates perspectives from molecular, cellular, systems levels. In particular, neuropharmacology provides neurotransmitter receptor systems, aiding investigation mechanisms underlying regulation potential therapeutic targets. A notable player this context cortisol, hormone, which significantly both memory reconsolidation Gaining thorough intricate interactions has implications terms addressing psychiatric disorders related stress. This review sheds light on complex between processes, emotions, their neural bases. endeavor, our aim reshape comprehension fear, stress, emotional well-being, ultimately development interventions.

Язык: Английский

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Navigating the garden of forking paths for data exclusions in fear conditioning research

eLife, Год журнала: 2019, Номер 8

Опубликована: Дек. 16, 2019

In this report, we illustrate the considerable impact of researcher degrees freedom with respect to exclusion participants in paradigms a learning element. We empirically through case examples from human fear conditioning research, which 'non-learners' and 'non-responders' is common - despite lack consensus on how define these groups. substantial heterogeneity criteria identified systematic literature search highlight potential problems pitfalls different definitions based re-analyses existing data sets. On basis studies, propose evidence-based rather than idiosyncratic criteria, including clear guidelines reporting details. Taken together, flexibility collection analysis can be avoided, will benefit robustness replicability research findings expected applicable other fields that involve

Язык: Английский

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