Association of Preterm Birth and Socioeconomic Status With Neonatal Brain Structure DOI Creative Commons
K. I. M. McKinnon, Paola Galdi, Manuel Blesa

и другие.

JAMA Network Open, Год журнала: 2023, Номер 6(5), С. e2316067 - e2316067

Опубликована: Май 31, 2023

Importance Preterm birth and socioeconomic status (SES) are associated with brain structure in childhood, but the relative contributions of each during neonatal period unknown. Objective To investigate associations gestational age (GA) SES morphology by testing 3 hypotheses: GA morphology; between vary GA; depend on how is operationalized. Design, Setting, Participants This cohort study recruited participants from November 2016 to September 2021 at a single center United Kingdom. were 170 extremely very preterm infants 91 full-term or near-term infants. Exclusion criteria major congenital malformation, chromosomal abnormality, infection, cystic periventricular leukomalacia, hemorrhagic parenchymal infarction, posthemorrhagic ventricular dilatation. Exposures Birth SES, operationalized neighborhood level (using Scottish Index Multiple Deprivation), family parental education occupation), subjectively (World Health Organization Quality Life measure). Main Outcomes Measures Brain volume (85 parcels) 5 whole-brain cortical measures (gyrification index, thickness, sulcal depth, curvature, surface area) term-equivalent (median [range] age, 40 weeks, days [36 2 45 6 days] 42 weeks [38 46 1 day] for infants, respectively). Results (95 [55.9%] male; 4 166 [2.4%] Asian, 145 [87.3%] White) (50 [54.9%] 86 [3.5%] 78 [90.7%] White infants) median (range) GAs 30 0 (22 day, 32 days) 39 (36 days, day), respectively. In fully adjusted models, was higher proportion volumes (27 85 parcels [31.8%]; β range, −0.20 0.24) than neighborhood-level (1 [1.2%]; = 0.17 [95% CI, −0.16 0.50]) family-level (maternal education: [4.7%]; 0.09 0.15; maternal occupation: 0.06 0.02 0.11] There interactions both subjective regional volumes. area (β 0.10 0.18]) gyrification index 0.16 0.07 0.25]); no measure measures. Conclusions Relevance this UK morphology, low had more widely distributed SES. Further work warranted elucidate mechanisms underlying association early development.

Язык: Английский

Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis DOI Creative Commons
Anna Vannucci, Andrea Fields, Eleanor Hansen

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 150, С. 105210 - 105210

Опубликована: Май 3, 2023

Язык: Английский

Процитировано

19
Neighborhood poverty during childhood prospectively predicts adolescent functional brain network architecture DOI Creative Commons
Cleanthis Michael, Scott Tillem, Chandra Sripada

и другие.

Developmental Cognitive Neuroscience, Год журнала: 2023, Номер 64, С. 101316 - 101316

Опубликована: Окт. 14, 2023

Family poverty has been associated with altered brain structure, function, and connectivity in youth. However, few studies have examined how disadvantage within the broader neighborhood may influence functional network organization. The present study leveraged a longitudinal community sample of 538 twins living low-income neighborhoods to evaluate prospective association between exposure during childhood (6-10 y) architecture adolescence (8-19 y). Using resting-state task-based fMRI, we generated two latent measures that captured intrinsic organization across whole-brain levels - segregation segregation-integration balance. While age was positively balance overall sample, these associations were moderated by poverty. Specifically, positive observed only youth from more, but not less, disadvantaged neighborhoods. Moreover, greater predicted reduced early, middle or late, adolescence. These effects detected both system as well specific networks, including fronto-parietal, default mode, salience, subcortical systems. findings indicate where children live exert long-reaching on development adolescent brain.

Язык: Английский

Процитировано

18
The Role of School Environment in Brain Structure, Connectivity, and Mental Health in Children: A Multimodal Investigation DOI Creative Commons
Divyangana Rakesh, Andrew Zalesky, Sarah Whittle

и другие.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2022, Номер 8(1), С. 32 - 41

Опубликована: Фев. 2, 2022

Язык: Английский

Процитировано

26
Socioeconomic resources are associated with distributed alterations of the brain’s intrinsic functional architecture in youth DOI Creative Commons
Chandra Sripada, Arianna M. Gard, Mike Angstadt

и другие.

Developmental Cognitive Neuroscience, Год журнала: 2022, Номер 58, С. 101164 - 101164

Опубликована: Окт. 17, 2022

Little is known about how exposure to limited socioeconomic resources (SER) in childhood gets "under the skin" shape brain development, especially using rigorous whole-brain multivariate methods large, adequately powered samples. The present study examined resting state functional connectivity patterns from 5821 youth Adolescent Brain Cognitive Development (ABCD) study, employing across three levels: whole-brain, network-wise, and connection-wise. Across all levels, SER was associated with widespread alterations connectome. However, critically, we found that parental education primary driver of neural associations SER. These developing connectome exhibited notable concentrations somatosensory subcortical regions, they were partially accounted for by home enrichment activities, child's cognitive abilities, grades, indicating interwoven links between education, child stimulation, performance. results add a new data-driven, perspective on household

Язык: Английский

Процитировано

24
Association of Preterm Birth and Socioeconomic Status With Neonatal Brain Structure DOI Creative Commons
K. I. M. McKinnon, Paola Galdi, Manuel Blesa

и другие.

JAMA Network Open, Год журнала: 2023, Номер 6(5), С. e2316067 - e2316067

Опубликована: Май 31, 2023

Importance Preterm birth and socioeconomic status (SES) are associated with brain structure in childhood, but the relative contributions of each during neonatal period unknown. Objective To investigate associations gestational age (GA) SES morphology by testing 3 hypotheses: GA morphology; between vary GA; depend on how is operationalized. Design, Setting, Participants This cohort study recruited participants from November 2016 to September 2021 at a single center United Kingdom. were 170 extremely very preterm infants 91 full-term or near-term infants. Exclusion criteria major congenital malformation, chromosomal abnormality, infection, cystic periventricular leukomalacia, hemorrhagic parenchymal infarction, posthemorrhagic ventricular dilatation. Exposures Birth SES, operationalized neighborhood level (using Scottish Index Multiple Deprivation), family parental education occupation), subjectively (World Health Organization Quality Life measure). Main Outcomes Measures Brain volume (85 parcels) 5 whole-brain cortical measures (gyrification index, thickness, sulcal depth, curvature, surface area) term-equivalent (median [range] age, 40 weeks, days [36 2 45 6 days] 42 weeks [38 46 1 day] for infants, respectively). Results (95 [55.9%] male; 4 166 [2.4%] Asian, 145 [87.3%] White) (50 [54.9%] 86 [3.5%] 78 [90.7%] White infants) median (range) GAs 30 0 (22 day, 32 days) 39 (36 days, day), respectively. In fully adjusted models, was higher proportion volumes (27 85 parcels [31.8%]; β range, −0.20 0.24) than neighborhood-level (1 [1.2%]; = 0.17 [95% CI, −0.16 0.50]) family-level (maternal education: [4.7%]; 0.09 0.15; maternal occupation: 0.06 0.02 0.11] There interactions both subjective regional volumes. area (β 0.10 0.18]) gyrification index 0.16 0.07 0.25]); no measure measures. Conclusions Relevance this UK morphology, low had more widely distributed SES. Further work warranted elucidate mechanisms underlying association early development.

Язык: Английский

Процитировано

16