Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Март 11, 2024

Abstract Diet, serving as a vital source of nutrients, exerts profound influence on human health and disease progression. Recently, dietary interventions have emerged promising adjunctive treatment strategies not only for cancer but also neurodegenerative diseases, autoimmune cardiovascular metabolic disorders. These demonstrated substantial potential in modulating metabolism, trajectory, therapeutic responses. Metabolic reprogramming is hallmark malignant progression, deeper understanding this phenomenon tumors its effects immune regulation significant challenge that impedes eradication. Dietary intake, key environmental factor, can tumor metabolism. Emerging evidence indicates might affect the nutrient availability tumors, thereby increasing efficacy treatments. However, intricate interplay between pathogenesis other diseases complex. Despite encouraging results, mechanisms underlying diet-based remain largely unexplored, often resulting underutilization management. In review, we aim to illuminate various interventions, including calorie restriction, fasting-mimicking diet, ketogenic protein restriction high-salt high-fat high-fiber aforementioned diseases. We explore multifaceted impacts these encompassing their immunomodulatory effects, biological impacts, molecular mechanisms. This review offers valuable insights into application therapies

Язык: Английский

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Dietary Patterns and Alzheimer’s Disease: An Updated Review Linking Nutrition to Neuroscience

Nutrients, Год журнала: 2023, Номер 15(14), С. 3204 - 3204

Опубликована: Июль 19, 2023

Alzheimer's disease (AD) is a growing concern for the aging population worldwide. With no current cure or reliable treatments available AD, prevention an important and area of research. A range lifestyle dietary patterns have been studied to identify most effective preventive changes against AD related dementia (ADRD) pathology. Of these, are Mediterranean, DASH, MIND, ketogenic, modified Mediterranean-ketogenic diets. However, there discrepancies in reported benefits among studies examining these patterns. We herein compile narrative/literature review existing clinical evidence on association with ADRD symptomology contemplate their preventive/ameliorative effects neuropathology various milieus. By large, plant-based found be relatively consistently positively correlated preventing reducing odds ADRD. These impacts stem not only from direct impact specific components within brain but also indirect through decreasing deleterious risk factors, such as diabetes, obesity, cardiovascular diseases. Importantly, other psychosocial factors influence intake, social connection, which may directly diet lifestyle, thereby impacting risk. To this end, prospective research should include holistic approach, including considerations.

Язык: Английский

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The Role of Diet and Gut Microbiota in Alzheimer’s Disease

Nutrients, Год журнала: 2024, Номер 16(3), С. 412 - 412

Опубликована: Янв. 31, 2024

Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by accumulation amyloid-beta (Aβ) plaques and hyperphosphorylated tau tangles. Currently, (AD) impacts 50 million individuals, with projections anticipating an increase to 152 year 2050. Despite increasing global prevalence AD, its underlying pathology remains poorly understood, posing challenges for early diagnosis treatment. Recent research suggests a link between gut dysbiosis aggregation Aβ, development proteins, occurrence neuroinflammation oxidative stress are associated AD. However, investigations into gut–brain axis (GBA) in context AD progression have yielded inconsistent findings. This review aims enhance our understanding microbial diversity at species level role these pathology. Additionally, this addresses influence confounding elements, including diet, probiotics, prebiotics, on throughout different stages (preclinical, mild cognitive impairment (MCI), AD) progression.

Язык: Английский

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The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117207 - 117207

Опубликована: Июль 26, 2024

Язык: Английский

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Overlooked cases of mild cognitive impairment: Implications to early Alzheimer’s disease

Ageing Research Reviews, Год журнала: 2024, Номер 98, С. 102335 - 102335

Опубликована: Май 12, 2024

Язык: Английский

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Gut Microbiota and its Metabolites: Bridge of Dietary Nutrients and Alzheimer’s Disease

Advances in Nutrition, Год журнала: 2023, Номер 14(4), С. 819 - 839

Опубликована: Апрель 17, 2023

Alzheimer's disease (AD) is a neurodegenerative characterized by progressive cognitive impairment and neuroinflammation. Recent research has revealed the crucial role of gut microbiota microbial metabolites in modulating AD. However, mechanisms which microbiome affect brain function remain poorly understood. Here, we review literature on changes diversity composition patients with AD animal models We also discuss latest progress understanding pathways from host or diet regulate By effects dietary components function, composition, metabolites, examine potential for manipulation through intervention to delay progression Although it challenging translate our microbiome-based approaches guidelines clinical therapies, these findings provide an attractive target promoting function.

Язык: Английский

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The role of lifestyle factors in cognitive health and dementia in oldest-old: A systematic review

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 152, С. 105286 - 105286

Опубликована: Июнь 15, 2023

Oldest-old is the fastest growing segment of society. A substantial number these individuals are cognitively impaired or demented. Given lack a cure, attention directed to lifestyle interventions that could help alleviate stress in patients, their families, and The aim this review was identify factors with important roles dementia prevention oldest-old. Searches were conducted PubMed, EMBASE, Scopus Web Science. We identified 27 observational cohort studies met inclusion criteria. Results showed eating healthy diet plenty fruits vegetables, participation leisure physical activities may protect against cognitive decline impairment among oldest-old regardless APOE genotype. Combined lifestyles generate multiplicative effects than individual factors. This first known systematically examine association between health Lifestyle for diet, leisure, combination be beneficial function Interventional warranted strengthen evidence.

Язык: Английский

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Ketogenic diet protects MPTP‐induced mouse model of Parkinson's disease via altering gut microbiota and metabolites

MedComm, Год журнала: 2023, Номер 4(3)

Опубликована: Май 16, 2023

Abstract The ketogenic diet (KD) is a low‐carbohydrate, high‐fat regime that protective against neurodegenerative diseases. However, the impact of KD on Parkinson's disease (PD) and its mechanisms remains unclear. 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced mouse model PD was fed with for 8 weeks. Motor function dopaminergic neurons were evaluated. Inflammation in brain, plasma, colon tissue also measured. Fecal samples assessed by 16S rDNA gene sequencing untargeted metabolomics. We found protected motor dysfunction, neuron loss, inflammation an MPTP PD. revealed administration significantly increased Citrobacter , Desulfovibrio Ruminococcus decreased Dubosiella whereas treatment reversed dysbiosis. Meanwhile, regulated MPTP‐induced histamine, N‐acetylputrescine, d ‐aspartic acid, other metabolites. microbiota transplantation using feces from KD‐treated mice attenuated impairment loss antibiotic‐pretreated mice. Our current study demonstrates played neuroprotective role through diet–gut microbiota–brain axis, which may involve brain colon. future research warranted to explore explicit anti‐inflammatory gut–brain axis models KD.

Язык: Английский

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The gut microbiota–brain axis in neurological disorders

MedComm, Год журнала: 2024, Номер 5(8)

Опубликована: Июль 20, 2024

Abstract Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as microbiota–gut–brain axis (MGBA). The MGBA influences host's nervous system development, emotional regulation, cognitive function through neurotransmitters, immune modulation, metabolic pathways. Factors like diet, lifestyle, genetics, environment shape composition together. Most research explored how regulates host physiology its potential in preventing treating neurological disorders. However, individual heterogeneity of microbiota, strains playing dominant role diseases, interactions these microbial metabolites with central/peripheral systems still need exploration. This review summarizes driving neurodevelopmental disorders (autism spectrum disorder attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's Parkinson's disease), mood (anxiety depression) recent years discusses current clinical preclinical microbe‐based interventions, including dietary intervention, probiotics, prebiotics, fecal transplantation. It also puts forward insufficient on provides framework for further

Язык: Английский

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Nutrition: A non‐negligible factor in the pathogenesis and treatment of Alzheimer's disease

Alzheimer s & Dementia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Abstract Alzheimer's disease (AD) is a degenerative characterized by progressive cognitive dysfunction. The strong link between nutrition and the occurrence progression of AD pathology has been well documented. Poor nutritional status accelerates progress potentially aggravating amyloid beta (Aβ) tau deposition, exacerbating oxidative stress response, modulating microbiota–gut–brain axis, disrupting blood–brain barrier function. advanced stage tends to lead malnutrition due impairments, sensory dysfunctions, brain atrophy, behavioral psychological symptoms dementia (BPSD). This, in turn, produces vicious cycle AD. This review discusses how factors deteriorate each other from early terminal stages AD, focusing on potential different levels factors, ranging micronutrients diet patterns. provides novel insights into reducing risk delaying its progression, improving prognosis. Highlights Two‐fifths cases worldwide have attributed modifiable factors. Up ≈26% community‐dwelling patients with are malnourished, compared 7%∼76% institutionalized patients. Undernutrition effects onset, prognosis through multiple mechanisms. Various supports were confirmed be protective for via specific

Язык: Английский

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