IUPHAR Themed Review: The Gut Microbiome in Schizophrenia DOI Creative Commons
Srinivas Kamath,

Elysia Sokolenko,

Kate Collins

и другие.

Pharmacological Research, Год журнала: 2024, Номер unknown, С. 107561 - 107561

Опубликована: Дек. 1, 2024

Gut microbial dysbiosis or altered gut consortium, in schizophrenia suggests a pathogenic role through the gut-brain axis, influencing neuroinflammatory and neurotransmitter pathways critical to psychotic, affective, cognitive symptoms. Paradoxically, conventional psychotropic interventions may exacerbate this dysbiosis, with antipsychotics, particularly olanzapine, demonstrating profound effects on architecture disruption of bacterial phyla ratios, diminished taxonomic diversity, attenuated short-chain fatty acid synthesis. To address these challenges, novel therapeutic strategies targeting microbiome, encompassing probiotic supplementation, prebiotic compounds, faecal microbiota transplantation, rationalised co-pharmacotherapy, show promise attenuating antipsychotic-induced metabolic disruptions while enhancing efficacy. Harnessing such insights, precision medicine approaches transform antipsychotic prescribing practices by identifying patients at risk side based their profiles. This IUPHAR review collates current literature landscape axis its intricate relationship advocating for integrating microbiome assessments management. Such fundamental shift proposing microbiome-informed prescriptions optimise efficacy reduce adverse impacts would align treatments safety, prioritising 'gut-neutral' gut-favourable drugs safeguard long-term patient outcomes therapy.

Язык: Английский

Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation DOI Creative Commons
Arik J. Hone, J. Michael McIntosh

Pharmacological Research, Год журнала: 2023, Номер 190, С. 106715 - 106715

Опубликована: Март 1, 2023

Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function such in the central peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs demonstrated immune cells. Furthermore, pathways where are expressed can be activated by endogenous ligands other than canonical agonists choline. In this review, we discuss involvement of a subset containing α7, α9, and/or α10 subunits modulation pain inflammation cholinergic anti-inflammatory pathway. Additionally, review most recent advances development novel their potential therapeutics.

Язык: Английский

Процитировано

56
Unraveling the peripheral nervous System's role in tumor: A Double-edged Sword DOI
Yanhao Wang, Yang Xuan,

Cuicui Liu

и другие.

Cancer Letters, Год журнала: 2025, Номер 611, С. 217451 - 217451

Опубликована: Янв. 8, 2025

Язык: Английский

Процитировано

3
The microbiota-gut-brain axis in hippocampus-dependent learning and memory: current state and future challenges DOI Creative Commons
Eloise J. Kuijer, Laura Steenbergen

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 152, С. 105296 - 105296

Опубликована: Июнь 26, 2023

A fundamental shift in neuroscience suggests bidirectional interaction of gut microbiota with the healthy and dysfunctional brain. This microbiota-gut-brain axis has mainly been investigated stress-related psychopathology (e.g. depression, anxiety). The hippocampus, a key structure both brain these psychopathologies, is implicated by work rodents that substantially impact hippocampal-dependent learning memory. However, understanding microbiota-hippocampus mechanisms health disease, translation to humans, hampered absence coherent evaluative approach. We review current knowledge regarding four main routes rodents: through vagus nerve; via hypothalamus-pituitary-adrenal-axis; metabolism neuroactive substances; modulation host inflammation. Next, we suggest an approach including testing (biomarkers of) as function influence (composition) on (dys)functioning. argue such necessary proceed from state preclinical research beneficial application humans optimise microbiota-based strategies treat enhance memory (dys)functions.

Язык: Английский

Процитировано

32
Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers DOI Creative Commons

Karina Carvalho Marques,

Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2023, Номер 10

Опубликована: Сен. 1, 2023

Long COVID is characterized by persistent signs and symptoms that continue or develop for more than 4 weeks after acute COVID-19 infection. Patients with experience a cardiovascular autonomic imbalance known as dysautonomia. However, the underlying pathophysiological mechanisms behind this remain unclear. Current hypotheses include neurotropism, cytokine storms, inflammatory persistence. Certain immunological factors indicate autoimmune dysfunction, which can be used to identify patients at higher risk of COVID. Heart rate variability imbalances in individuals suffering from COVID, measurement non-invasive low-cost method assessing modulation. Additionally, biochemical markers are diagnosing monitoring These improve understanding driving response its effects on sympathetic parasympathetic pathways nervous system. Autonomic may result lower heart variability, impaired vagal activity, substantial sympathovagal imbalance. New research subject must encouraged enhance long-term risks cause

Язык: Английский

Процитировано

30
Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies DOI Creative Commons

Sergio Giunta,

Shijin Xia, Giuseppe Pelliccioni

и другие.

GeroScience, Год журнала: 2023, Номер 46(1), С. 113 - 127

Опубликована: Окт. 11, 2023

Abstract Inflammaging refers to the age-related low grade, sterile, chronic, systemic, and long-lasting subclinical, proinflammatory status, currently recognized as main risk factor for development progression of most common diseases (ARDs). Extensive investigations were focused on a plethora stimuli that can fuel inflammaging, underestimating partly neglecting important endogenous anti-inflammaging mechanisms could play crucial role in such state. Studies autonomic nervous system (ANS) functions during aging highlighted an imbalance toward overactive sympathetic (SNS) tone, promoting conditions, diminished parasympathetic (PNS) activity, playing anti-inflammatory effects mediated by so called cholinergic pathway (CAP). At molecular level, CAP is characterized signals communicated via vagus nerve (with possible involvement splenic nerves) through acetylcholine release downregulate inflammatory actions macrophages, key players inflammaging. Notably, decreased vagal function increased burden activated/senescent macrophages (macrophaging) probably precede several factors diseases, while reduced macrophaging be associated with relevant reduction profiles. Hypothalamic–pituitary–adrenal axis (HPA axis) another related ANS some response mainly cortisol levels. In this perspective review, we HPA, representing broadly “anti-inflammaging” mechanisms, have efficacy lose effectiveness aged people, phenomenon contribute framework, strategies aimed re-balance PNS/SNS activities explored modulate systemic inflammaging especially at early subclinical stage, thus increasing chances reach extreme limit human lifespan healthy status.

Язык: Английский

Процитировано

24
Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4/NF-κB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer’s disease mice DOI Creative Commons
H. Ni,

Muqiu Liu,

Mindie Cao

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 171, С. 116190 - 116190

Опубликована: Янв. 26, 2024

Sinomenine (SIN), an alkaloid extracted from the Chinese herbal medicine Sinomenium acutum, has great potential in anti-inflammatory, immune regulation, analgesic and sedative, is already a clinical drug for treatment of rheumatoid arthritis China. Our previous studies show SIN inhibits inflammation by regulating ɑ7nAChR, key receptor cholinergic anti-inflammatory pathway (CAP), which plays important role peripheral central nervous system inflammation. Growing evidence supports dysregulation inflammatory responses play pathogenesis AD. The intervention effects on AD CAP homeostasis brain gut were analyzed first time present study using scopolamine-induced model mice. Behavioral tests used to assess cognitive performance. neurons loss, function, responses, biological barrier function mouse intestinal tissues evaluated through variety techniques, microbiota was detected 16SrRNA sequencing. results showed that significantly inhibited decline, system, inflammation, damage as well flora disturbance caused SCOP More importantly, effectively regulated suppress activation TLR4/NF-κB protect alleviate impairment.

Язык: Английский

Процитировано

15
Organ crosstalk and dysfunction in sepsis DOI Creative Commons
André Borges, Luís Bento

Annals of Intensive Care, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 19, 2024

Язык: Английский

Процитировано

10
Electroacupuncture promotes resolution of inflammation by modulating SPMs via vagus nerve activation in LPS-induced ALI DOI
Yan Huang, Shuan Dong, Yuan Zhang

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 147, С. 113941 - 113941

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Crosstalk between the peripheral nervous system and breast cancer influences tumor progression DOI
Jianming Hu, Wuzhen Chen,

Lesang Shen

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2022, Номер 1877(6), С. 188828 - 188828

Опубликована: Окт. 22, 2022

Язык: Английский

Процитировано

33
Nicotinic Acetylcholine Receptor Dysfunction in Addiction and in Some Neurodegenerative and Neuropsychiatric Diseases DOI Creative Commons

Ana Sofía Vallés,

Francisco J. Barrantes

Cells, Год журнала: 2023, Номер 12(16), С. 2051 - 2051

Опубликована: Авг. 11, 2023

The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. focuses on the nicotinic acetylcholine (nAChR) its addiction neurodegenerative neuropsychiatric diseases epilepsy. Cholinergic dysfunction is associated with inflammatory processes mainly involvement of α7 nAChRs expressed peripheral immune cells. Evidence suggests these neuroinflammatory trigger aggravate pathological states. We discuss preclinical evidence demonstrating therapeutic potential nAChR ligands Alzheimer disease, Parkinson schizophrenia spectrum disorders, autosomal dominant sleep-related hypermotor PubMed Google Scholar bibliographic databases were searched keywords indicated below.

Язык: Английский

Процитировано

20