Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
97(4), С. 1737 - 1749
Опубликована: Фев. 2, 2024
Working
memory
deficits
in
Alzheimer's
disease
(AD)
are
linked
to
impairments
the
retrieval
of
stored
information.
However,
research
on
mechanism
impaired
working
is
still
lacking.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 30, 2024
Abstract
Alzheimer's
disease
is
characterized
by
memory
loss
and
pathological
changes
in
the
brain
such
as
amyloid
beta
tau
pathology,
well
irregular
neural
network
activity.
We
studied
how
intranasal
insulin
impacts
oscillations
an
rat
model
induced
STZ.
Male
Wistar
rats
were
subjected
to
intracerebroventricular
STZ
injection,
followed
therapy.
Electrophysiological
recordings
conducted
hippocampus
medial
prefrontal
cortex
assess
local
field
potentials,
elucidating
insignificant
alterations
theta-gamma
following
treatment.
However,
administration
ameliorated
deficits
hippocampal
sharp-wave
ripples
augmented
hippocampal-prefrontal
theta
coherence.
Concurrently,
therapy
conferred
enhancements
spatial
object
recognition
performance
behavioral
tests.
Furthermore,
mitigated
protein
pathology
neuronal
loss.
Our
findings
underscore
potential
of
enhance
function
via
modulating
cortical
synchronization
alleviating
impairments
ripples.
Frontiers in Cellular Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Май 17, 2023
Chronic
cerebral
hypoperfusion
(CCH)
is
increasingly
recognized
as
a
common
cognitive
impairment-causing
mechanism.
However,
no
clinically
effective
drugs
to
treat
impairment
due
CCH
have
been
identified.
An
abnormal
distribution
of
neural
oscillations
was
found
in
the
hippocampus
rats.
By
releasing
various
neurotransmitters,
distinct
afferent
fibers
influence
neuronal
hippocampus.
Enriched
environments
(EE)
are
known
improve
levels
by
modulating
neurotransmitter
homeostasis.
Using
EE
an
intervention,
we
examined
three
classical
neurotransmitters
and
dynamics
rat
model.
The
results
showed
that
significantly
improved
balance
(acetylcholine,
glutamate,
GABA)
hippocampus,
enhanced
strength
theta
slow-gamma
(SG)
rhythms,
dramatically
coupling
across
frequency
bands
Furthermore,
expression
vesicular
transporters-vesicular
acetylcholine
transporters
(VAChT)
GABA
(VGAT)-was
reduced
rats,
whereas
glutamate
transporter
1
(VGLUT1)
abnormally
elevated.
partially
restored
protein
maintain
hippocampal
neurotransmitters.
More
importantly,
causal
mediation
analysis
increased
power
rhythm
increasing
level
VAChT
VGAT,
which
then
phase
amplitude
theta-SG
finally
led
improvement
CCH.
These
findings
shed
light
on
role
disruption
oscillations.
This
study
has
implications
for
our
knowledge
disease
pathways.
Journal of Alzheimer s Disease,
Год журнала:
2023,
Номер
97(2), С. 659 - 677
Опубликована: Дек. 19, 2023
Neuroimaging
studies
investigating
the
behavioral
and
psychological
symptoms
of
dementia
(BPSD)-
such
as
apathy,
anxiety,
depression-
have
linked
some
these
with
altered
neural
activity.
However,
inconsistencies
in
operational
definitions
rating
scales,
limited
scope
assessments,
poor
temporal
resolution
imaging
techniques
hampered
human
studies.
Many
transgenic
(Tg)
mouse
models
Alzheimer's
disease
(AD)
exhibit
BPSD-like
behaviors
concomitant
AD-related
neuropathology,
allowing
examination
how
activity
may
relate
to
high
spatial
resolution.
Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
97(4), С. 1737 - 1749
Опубликована: Фев. 2, 2024
Working
memory
deficits
in
Alzheimer's
disease
(AD)
are
linked
to
impairments
the
retrieval
of
stored
information.
However,
research
on
mechanism
impaired
working
is
still
lacking.