Reduced Prefrontal-Thalamic Theta Flow During Working Memory Retrieval in APP/PS1 Mice DOI Creative Commons
Shengnan Zhang,

Hongrui Ai,

Jia Wang

и другие.

Journal of Alzheimer s Disease, Год журнала: 2024, Номер 97(4), С. 1737 - 1749

Опубликована: Фев. 2, 2024

Working memory deficits in Alzheimer's disease (AD) are linked to impairments the retrieval of stored information. However, research on mechanism impaired working is still lacking.

Язык: Английский

Cognitive improvement via a modulated rhythmic pulsed magnetic field in D-galactose-induced accelerated aging mice DOI
Pingping Wang, Xue Wang,

Qingmeng Wang

и другие.

Brain Research, Год журнала: 2023, Номер 1810, С. 148372 - 148372

Опубликована: Апрель 23, 2023

Язык: Английский

Процитировано

2
Hippocampal sharp-wave ripple and hippocampal-prefrontal synchrony regulate memory-enhancing effects of intranasal insulin in an STZ-induced Alzheimer’s model DOI Creative Commons

Farnaz Karimani,

Afsaneh Asgari Taei,

Neda Kaveh

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 30, 2024

Abstract Alzheimer's disease is characterized by memory loss and pathological changes in the brain such as amyloid beta tau pathology, well irregular neural network activity. We studied how intranasal insulin impacts oscillations an rat model induced STZ. Male Wistar rats were subjected to intracerebroventricular STZ injection, followed therapy. Electrophysiological recordings conducted hippocampus medial prefrontal cortex assess local field potentials, elucidating insignificant alterations theta-gamma following treatment. However, administration ameliorated deficits hippocampal sharp-wave ripples augmented hippocampal-prefrontal theta coherence. Concurrently, therapy conferred enhancements spatial object recognition performance behavioral tests. Furthermore, mitigated protein pathology neuronal loss. Our findings underscore potential of enhance function via modulating cortical synchronization alleviating impairments ripples.

Язык: Английский

Процитировано

0
Enriched environment attenuates hippocampal theta and gamma rhythms dysfunction in chronic cerebral hypoperfusion via improving imbalanced neural afferent levels DOI Creative Commons
Jiaxin Zheng,

Sisi Peng,

Lingling Cui

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Май 17, 2023

Chronic cerebral hypoperfusion (CCH) is increasingly recognized as a common cognitive impairment-causing mechanism. However, no clinically effective drugs to treat impairment due CCH have been identified. An abnormal distribution of neural oscillations was found in the hippocampus rats. By releasing various neurotransmitters, distinct afferent fibers influence neuronal hippocampus. Enriched environments (EE) are known improve levels by modulating neurotransmitter homeostasis. Using EE an intervention, we examined three classical neurotransmitters and dynamics rat model. The results showed that significantly improved balance (acetylcholine, glutamate, GABA) hippocampus, enhanced strength theta slow-gamma (SG) rhythms, dramatically coupling across frequency bands Furthermore, expression vesicular transporters-vesicular acetylcholine transporters (VAChT) GABA (VGAT)-was reduced rats, whereas glutamate transporter 1 (VGLUT1) abnormally elevated. partially restored protein maintain hippocampal neurotransmitters. More importantly, causal mediation analysis increased power rhythm increasing level VAChT VGAT, which then phase amplitude theta-SG finally led improvement CCH. These findings shed light on role disruption oscillations. This study has implications for our knowledge disease pathways.

Язык: Английский

Процитировано

1
Aberrant Cortical Activity in 5xFAD Mice in Response to Social and Non-Social Olfactory Stimuli DOI
Filip Kosel, Mackenzie Rae Hartley, Tamara B. Franklin

и другие.

Journal of Alzheimer s Disease, Год журнала: 2023, Номер 97(2), С. 659 - 677

Опубликована: Дек. 19, 2023

Neuroimaging studies investigating the behavioral and psychological symptoms of dementia (BPSD)- such as apathy, anxiety, depression- have linked some these with altered neural activity. However, inconsistencies in operational definitions rating scales, limited scope assessments, poor temporal resolution imaging techniques hampered human studies. Many transgenic (Tg) mouse models Alzheimer's disease (AD) exhibit BPSD-like behaviors concomitant AD-related neuropathology, allowing examination how activity may relate to high spatial resolution.

Язык: Английский

Процитировано

1
Reduced Prefrontal-Thalamic Theta Flow During Working Memory Retrieval in APP/PS1 Mice DOI Creative Commons
Shengnan Zhang,

Hongrui Ai,

Jia Wang

и другие.

Journal of Alzheimer s Disease, Год журнала: 2024, Номер 97(4), С. 1737 - 1749

Опубликована: Фев. 2, 2024

Working memory deficits in Alzheimer's disease (AD) are linked to impairments the retrieval of stored information. However, research on mechanism impaired working is still lacking.

Язык: Английский

Процитировано

0