CaMKII modulates memory destabilization by regulating the interaction of theta and gamma oscillations DOI Creative Commons
Martı́n Cammarota, Janine I. Rossato, María Carolina González

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Object recognition memory (ORM) allows animals to distinguish between novel and familiar items. When reactivated during recall in the presence of a object, consolidated ORM can be destabilized linked that generated by object through reconsolidation. The CA1 region dorsal hippocampus contributes destabilization reconsolidation mechanisms involving theta/gamma cross-frequency coupling (hPAC) synaptic plasticity modulation. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is vital for hippocampus-dependent processing has been associated with theta activity-dependent CA1. However, specific role hippocampal CaMKII lasting storage remains unclear, its potential impact on memory-related oscillatory activity not previously investigated. To explore these questions, we employed combination behavioral, electrophysiological, pharmacological approaches at various stages processing, found necessary or but does regulate novelty-induced modulating hPAC.

Language: Английский

Reduced Prefrontal-Thalamic Theta Flow During Working Memory Retrieval in APP/PS1 Mice DOI Creative Commons
Shengnan Zhang,

Hongrui Ai,

Jia Wang

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 97(4), P. 1737 - 1749

Published: Feb. 2, 2024

Working memory deficits in Alzheimer's disease (AD) are linked to impairments the retrieval of stored information. However, research on mechanism impaired working is still lacking.

Language: Английский

Citations

0
Hippocampal sharp-wave ripple and hippocampal-prefrontal synchrony regulate memory-enhancing effects of intranasal insulin in an STZ-induced Alzheimer’s model DOI Creative Commons

Farnaz Karimani,

Afsaneh Asgari Taei,

Neda Kaveh

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 30, 2024

Abstract Alzheimer's disease is characterized by memory loss and pathological changes in the brain such as amyloid beta tau pathology, well irregular neural network activity. We studied how intranasal insulin impacts oscillations an rat model induced STZ. Male Wistar rats were subjected to intracerebroventricular STZ injection, followed therapy. Electrophysiological recordings conducted hippocampus medial prefrontal cortex assess local field potentials, elucidating insignificant alterations theta-gamma following treatment. However, administration ameliorated deficits hippocampal sharp-wave ripples augmented hippocampal-prefrontal theta coherence. Concurrently, therapy conferred enhancements spatial object recognition performance behavioral tests. Furthermore, mitigated protein pathology neuronal loss. Our findings underscore potential of enhance function via modulating cortical synchronization alleviating impairments ripples.

Language: Английский

Citations

0
TRanscranial AlterNating current stimulation FOR patients with mild Alzheimer’s Disease (TRANSFORM-AD): a randomized controlled clinical trial DOI Creative Commons
Yi Tang, Yi Xing, Liwei Sun

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 12, 2024

Language: Английский

Citations

0
Hippocampal sharp-wave ripples and hippocampal-prefrontal synchrony regulate memory-enhancing effects of intranasal insulin in an STZ-induced Alzheimer's model DOI

Farnaz Karimani,

Afsaneh Asgari Taei,

Neda Kaveh

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123094 - 123094

Published: Oct. 1, 2024

Language: Английский

Citations

0
CaMKII modulates memory destabilization by regulating the interaction of theta and gamma oscillations DOI Creative Commons
Martı́n Cammarota, Janine I. Rossato, María Carolina González

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Object recognition memory (ORM) allows animals to distinguish between novel and familiar items. When reactivated during recall in the presence of a object, consolidated ORM can be destabilized linked that generated by object through reconsolidation. The CA1 region dorsal hippocampus contributes destabilization reconsolidation mechanisms involving theta/gamma cross-frequency coupling (hPAC) synaptic plasticity modulation. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is vital for hippocampus-dependent processing has been associated with theta activity-dependent CA1. However, specific role hippocampal CaMKII lasting storage remains unclear, its potential impact on memory-related oscillatory activity not previously investigated. To explore these questions, we employed combination behavioral, electrophysiological, pharmacological approaches at various stages processing, found necessary or but does regulate novelty-induced modulating hPAC.

Language: Английский

Citations

0