It
is
hard
to
overestimate
the
influence
of
endocannabinoid
signaling
(ECS)
system
on
central
nervous
(CNS)
function.
In
40
years
since
cannabinoids
were
found
trigger
specific
cell
cascades,
studies
ECS
continue
cause
amazement,
surprise,
and
confusion!
CB1
cannabinoid
receptors
are
expressed
widely
in
CNS
regulate
cell-cell
communication
via
effects
release
both
neurotransmitters
gliotransmitters.
CB2
difficult
detect
but
seem
"punch
above
their
weight"
as
compounds
targeting
these
have
significant
inflammatory
state
behavior.
Positive
negative
allosteric
modulators
for
been
identified
examined
preclinical
studies.
Concentrations
ligands,
N-arachidonoylethanolamine
2-arachidonoylglycerol
(2-AG),
regulated
by
a
combination
enzymatic
synthesis
degradation
inhibitors
processes
available
making
way
into
clinical
trials.
Importantly,
regulates
many
essential
brain
functions,
including
regulation
reward,
anxiety,
inflammation,
motor
control,
cellular
development.
While
field
cusp
discoveries
providing
impactful
therapeutic
insights
disorders,
there
still
much
be
learned
about
this
remarkable
versatile
modulatory
system.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
152, С. 113208 - 113208
Опубликована: Май 31, 2022
This
study
aimed
to
reveal
the
classical
signal
pathways
and
important
potential
targets
of
traditional
Chinese
medicine
(TCM)
for
treating
Alzheimer's
disease
(AD),
provide
support
further
investigation
on
TCM
its
active
ingredients.Literature
survey
was
conducted
using
PubMed,
Web
Science,
Google
Scholar,
CNKI,
other
databases,
with
"Alzheimer's
disease,"
"traditional
medicine,"
"medicinal
herb,"
"Chinese
"natural
plant"
as
primary
keywords.TCM
could
modulate
related
AD
pathological
progression,
including
NF-κB,
Nrf2,
JAK/STAT,
ubiquitin-proteasome
pathway,
autophagy-lysosome
pathway-related
AMPK/mTOR,
GSK-3/mTOR,
PI3K/Akt/mTOR,
well
SIRT1
PPARα
pathway.
It
regulate
crosstalk
between
through
a
multitarget,
thus
maintaining
chronic
inflammatory
interaction
balance,
inhibiting
oxidative
stress
damage,
regulating
system
function,
modulating
autophagy,
eventually
improving
cognitive
impairment
in
patients
AD.TCM
be
multilevel,
multitargeted,
multifaceted
prevent
treat
AD.
In-depth
research
prevention
treatment
new
ideas
exploring
pathogenesis
developing
anti-AD
drugs.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(6), С. 3169 - 3189
Опубликована: Апрель 14, 2024
Abstract
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
the
accumulation
of
amyloid‐beta
plaques
and
neurofibrillary
tangles,
leading
to
neuronal
loss.
Curcumin,
polyphenolic
compound
derived
from
Curcuma
longa
,
has
shown
potential
neuroprotective
effects
due
its
anti‐inflammatory
antioxidant
properties.
This
review
aims
synthesize
current
preclinical
data
on
anti‐neuroinflammatory
mechanisms
curcumin
in
context
AD,
addressing
pharmacokinetics,
bioavailability,
as
therapeutic
adjunct.
An
exhaustive
literature
search
was
conducted,
focusing
recent
studies
within
last
10
years
related
curcumin's
impact
neuroinflammation
role
AD.
The
methodology
included
sourcing
articles
specialized
databases
using
specific
medical
subject
headings
terms
ensure
precision
relevance.
Curcumin
demonstrates
significant
properties
modulating
neuroinflammatory
pathways,
scavenging
reactive
oxygen
species,
inhibiting
production
pro‐inflammatory
cytokines.
Despite
potential,
challenges
remain
regarding
limited
bioavailability
scarcity
comprehensive
human
clinical
trials.
emerges
promising
adjunct
AD
multimodal
benefits.
However,
further
research
required
overcome
establish
effective
dosing
regimens
subjects.
Developing
novel
delivery
systems
formulations
may
enhance
treatment.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 24, 2022
Parkinson's
disease
(PD)
is
one
of
the
most
common
and
chronic
degenerative
diseases
in
central
nervous
system.
The
main
pathology
PD
formation
progressive
loss
dopaminergic
neurons
substantia
nigra
α-synuclein-rich
Lewy
bodies.
pathogenesis
not
caused
by
any
single
independent
factor.
diversity
these
factors
PD,
such
as
iron
accumulation,
oxidative
stress,
neuroinflammation,
mitochondrial
dysfunction,
age,
environment,
heredity,
makes
research
progress
slow.
Nrf2
has
been
well-known
to
be
closely
associated
with
could
regulate
induced
development.
activation
protect
slow
down
progression
PD.
This
review
summarized
role
pathway
on
Regulation
might
promising
strategies
prevent
treat
Journal of Asthma and Allergy,
Год журнала:
2024,
Номер
Volume 17, С. 97 - 112
Опубликована: Фев. 1, 2024
Abstract:
Allergy
rhinitis
(AR)
is
becoming
more
common
and
has
serious
medical
societal
consequences.
Sneezing,
paroxysmal
nasal
blockage,
itching,
mucosal
edema,
coughing,
rhinorrhea
are
symptoms
of
this
type
I
allergic
immunological
illness.
Immunoglobulin
E-mediated
inflammation
the
cause
it.
Because
AR
prone
to
recurrent
attacks,
extended
medication
therapy
may
impair
its
effectiveness.
In
addition
negatively
affecting
patients'
physical
health,
can
also
impact
their
mental
health.
During
development,
there
inflammatory
oxidative
stress
responses
that
linked
problems
in
a
number
signal
transduction
pathways.
By
using
terms
"allergic
rhinitis",
"traditional
Chinese
medicine",
"inflammation",
"oxidative
stress",
we
screened
for
pertinent
research
published
over
previous
five
years
databases
like
PubMed.
We
saw
NF-KB,
TLR,
IL-33/ST2,
PI3K/AKT,
MAPK,
Nrf2
some
most
important
pathways
AR.
Studies
have
revealed
antioxidant
anti-inflammatory
reduced
risk
was
therapeutic;
however,
varies
widely.
The
system
places
high
value
on
traditional
medicine
(TCM),
which
been
virtually
all
China's
5000-year
history.
influencing
signaling
related
stress,
herbal
constituent
compounds
shown
prevent
rhinitis.
This
review
will
focus
evidence
provide
references
clinical
treatment
scientific
applications.
Keywords:
rhinitis,
medicine,
inflammatory,
