Leaf extract ofAnacardium occidentaleameliorates biomarkers of neuroinflammation, memory loss, and neurobehavioral deficit in N(ω)-nitro-L-arginine methyl ester (L-NAME) treated rats DOI
Ademola Adetokunbo Oyagbemi, Adedeji K. Adebayo, Olamide Elizabeth Adebiyi

и другие.

Biomarkers, Год журнала: 2023, Номер 28(3), С. 263 - 272

Опубликована: Янв. 12, 2023

Purpose Anacardium occidentale commonly known as Cashew is a plant that widely used in African traditional medicine. It endowed with phytochemical constituents are responsible for its medicinal properties.Methods Twenty-five male Wistar rats were grouped follows: Control (Group A), Group B (L-NAME 40 mg/kg), C (100 mg/kg extract plus L-NAME), D (200 L-NAME) and E (10 of Lisinopril L-NAME). The animals treated oral administration either the extracts or Lisnopril daily 4 weeks. Neuro-behavioural tests such Morris Water Maze Hanging Wire Grip carried out to evaluate memory/spatial learning muscular strength, respectively. Makers oxidative stress, antioxidant enzymes immunohistochemical staining Glial Fibrillary Acidic Protein Ionised Calcium Binding Adaptor molecule 1 assessed.Results L-NAME caused significant increases biomarkers decreased status, acetylcholinesterase activity, altered neuro-behavioural changes, astrocytosis, microgliosis. However, reversed exaggerated stress improved changes.Conclusions Combining all, enhanced brain defence memory thus, suggesting neuroprotective properties occidentale.

Язык: Английский

Micronutrient Deficiency and Its Potential Role in Delirium Onset in Older Adults: A Systematic Review DOI Creative Commons
Chiara Ceolin, Mario Virgilio Papa, Marina De Rui

и другие.

The journal of nutrition health & aging, Год журнала: 2023, Номер 27(9), С. 785 - 790

Опубликована: Сен. 1, 2023

One of the pathogenetic hypotheses delirium is "neuroinflammatory theory" with consequent neurotoxicity brain connectivity networks. Micronutrients may play a significant role in prevention neuroinflammation. This systematic review addresses micronutrients development older populations. The EBSCO, Cochrane, PubMed, and Web Science databases were searched for articles on micronutrients. methodological quality studies included was evaluated Newcastle-Ottawa Scales observational case-control studies. 1326 papers identified from searches, 7 which met inclusion criteria (see section 2.3). All written English. Delirium predominantly secondary to post-operative dysfunction or acute medical conditions. By altering production neurotransmitters resulting an imbalance, by reducing their immunomodulatory increase inflammatory oxidative stress, micronutrient deficiency seems be associated increased incidence delirium. supports existence association between (i.e. cobalamin, thiamine, vitamin D) delirium, greater prevalence hospitalized patients.

Язык: Английский

Процитировано

12
The effects of vitamin D on different types of cells DOI

Mária Janubová,

Ingrid Žitňanová

Steroids, Год журнала: 2023, Номер 202, С. 109350 - 109350

Опубликована: Дек. 12, 2023

Язык: Английский

Процитировано

11
Vitamin D and canagliflozin combination alleviates Parkinson’s disease in rats through modulation of RAC1/NF-κB/Nrf2 interaction DOI
S Rizk, Eman Ali,

Alzahraa A. M. Sheref

и другие.

Immunopharmacology and Immunotoxicology, Год журнала: 2025, Номер unknown, С. 1 - 17

Опубликована: Март 25, 2025

Oxidative stress and neuroinflammation are crucial factors in the pathogenesis of Parkinson's disease (PD). Vitamin D (Vit D) canagliflozin (CAN) known to have anti-inflammatory antioxidant properties. Together, they target key molecular pathways involved PD, including oxidative neuroinflammation, specifically, small GTPase protein (RAC1)/nuclear factor-kappa B (NF-κB)/nuclear factor erythroid 2-related 2 (Nrf2) signaling, which regulates brain's inflammation. This study investigates effects Vit CAN alone combination a rat model PD. Fifty male Wistar rats were assigned five groups (n = 10), control, rotenone (ROT), + ROT, ROT. We assessed weight changes, brain weight, neurobehavioral functions, biochemical markers, immunohistopathology tissues. The results showed that treatment was more effective than alleviating PD symptoms, with offering best therapeutic outcome. therapy significantly improved serum D, striatal dopamine (DA) levels, status (reduced glutathione (GSH) catalase (CAT), reduced (malondialdehyde (MDA)), ameliorated inflammation (tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), 10 (IL-10)). Additionally, modulated expression RAC1, NF-κB, Nrf2, vitamin receptors (VDR), D-binding (DBP) immunoexpression tyrosine hydroxylase (TH), α-synuclein (α-SYN). These findings suggest synergistically modulate RAC1/NF-κB/Nrf2 pathway, leading neuroprotection

Язык: Английский

Процитировано

0
Vitamin D and Its Role on Inflammation, Oxidative Stress and Cardiovascular Disease DOI
Sandra Maria Barbalho, Lance Sloan, Adriano Cressoni Araújo

и другие.

Advances in biochemistry in health and disease, Год журнала: 2024, Номер unknown, С. 291 - 311

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

3
Vitamin D injection into the dorsal-CA1 hippocampus improves short-term sleep deprivation induced cognitive impairment in male rats DOI Creative Commons
Amir Rezagholizadeh, Amin Firoozi,

Zohreh Tavassoli

и другие.

Heliyon, Год журнала: 2024, Номер 10(15), С. e34853 - e34853

Опубликована: Июль 18, 2024

Язык: Английский

Процитировано

3
The neuroprotective effect of vitamin D in Parkinson's disease: association or causation DOI
Amin A. Hafiz

Nutritional Neuroscience, Год журнала: 2023, Номер 27(8), С. 870 - 886

Опубликована: Сен. 20, 2023

ABSTRACTParkinson's disease (PD) is a chronic neurodegenerative (NDD) due to the degeneration of dopaminergic neurons (DNs) in substantia nigra (SN). PD characterized by diverse motor symptoms such as rigidity, resting tremors, and bradykinesia, non-motor cognitive dysfunction sleep disturbances. Vitamin D (VD), VD receptor (VDR), metabolites are present brain play role maintaining development, differentiation, functions DNs. VDRs exert protective effects against neuropathology modulating functional capacity DNs neurotransmission SN. In virtue its anti-inflammatory antioxidant activities, could be effective prevention treatment PD. exerts neuroprotective effect reducing oxidative stress mitochondrial dysfunction, increasing autophagy brain-derived neurotrophic factor (BDNF). Low serum level connected with development dementia The VD-mediated augmenting interrelated safeguarding synaptic plasticity modulation neurotransmitter release. deficiency linked severity olfactory which precedes progression symptomatic However, precise remains unidentified, there conflict about whether can ameliorate or not.KEYWORDS: Parkinson's diseaseVitamin DVD receptorBDNFsubstantia nigraAutophagyOxidative stressdopaminergic AcknowledgementsNot applicable.Authors' contributionsAAH conceptualized manuscript, wrote, edited, reviewed main text approved final edition manuscript.Disclosure statementNo potential interest was reported author(s).Additional informationFundingThe author(s) no funding associated work featured this article.

Язык: Английский

Процитировано

6
Vitamin D: The crucial neuroprotective factor for nerve cells DOI

Yuxin Shi,

Yuchen Shi,

Jie Rao

и другие.

Neuroscience, Год журнала: 2024, Номер 560, С. 272 - 285

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

1
Leaf extract ofAnacardium occidentaleameliorates biomarkers of neuroinflammation, memory loss, and neurobehavioral deficit in N(ω)-nitro-L-arginine methyl ester (L-NAME) treated rats DOI
Ademola Adetokunbo Oyagbemi, Adedeji K. Adebayo, Olamide Elizabeth Adebiyi

и другие.

Biomarkers, Год журнала: 2023, Номер 28(3), С. 263 - 272

Опубликована: Янв. 12, 2023

Purpose Anacardium occidentale commonly known as Cashew is a plant that widely used in African traditional medicine. It endowed with phytochemical constituents are responsible for its medicinal properties.Methods Twenty-five male Wistar rats were grouped follows: Control (Group A), Group B (L-NAME 40 mg/kg), C (100 mg/kg extract plus L-NAME), D (200 L-NAME) and E (10 of Lisinopril L-NAME). The animals treated oral administration either the extracts or Lisnopril daily 4 weeks. Neuro-behavioural tests such Morris Water Maze Hanging Wire Grip carried out to evaluate memory/spatial learning muscular strength, respectively. Makers oxidative stress, antioxidant enzymes immunohistochemical staining Glial Fibrillary Acidic Protein Ionised Calcium Binding Adaptor molecule 1 assessed.Results L-NAME caused significant increases biomarkers decreased status, acetylcholinesterase activity, altered neuro-behavioural changes, astrocytosis, microgliosis. However, reversed exaggerated stress improved changes.Conclusions Combining all, enhanced brain defence memory thus, suggesting neuroprotective properties occidentale.

Язык: Английский

Процитировано

3