Acute Normobaric Hypoxia Lowers Executive Functions among Young Men despite Increase of BDNF Concentration

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(17), С. 10802 - 10802

Опубликована: Авг. 30, 2022

Background: Decreased SpO2 during hypoxia can cause cognitive function impairment, and the effects of acute on high-order brain functions such as executive processing remain unclear. This study’s goal was to examine impact an normobaric breathing session biological markers. Methods: Thirty-two healthy subjects participated in a blind study performing two sessions single 30 min bouts under conditions (normoxia (NOR) (NH), FIO2 = 0.135). The Stroop test applied assess function. Results: No significant difference observed interference “reading” part either condition; however, there increase “naming” NH (p 0.003), which corresponded decrease < 0.001). There 0.013) brain-derived neurotrophic factor (BDNF) level after compared baseline, not seen NOR. In addition, drop 0.001) cortisol levels NOR group slight elevation noticed. Conclusions: According these findings, delayed for motor execution reduced neural activity inhibitory processing. We also noted that this negative effect associated with decreased irrespective rise BDNF.

Язык: Английский

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Sensitivity of cognitive function tests to acute hypoxia in healthy subjects: a systematic literature review

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Окт. 11, 2023

Acute exposure to hypoxia can lead cognitive impairment. Therefore, may become a safety concern for occupational or recreational settings at altitude. Cognitive tests are used as tool assess the degree which affects performance. However, so many different that comparing studies is challenging. This structured literature evaluation provides an overview of effects acute on performance in healthy volunteers. Less frequently similar were clustered and classified into domains. Subsequently, test clusters compared sensitivity levels oxygen saturation. A total 38 articles complied with selection criteria, covering 86 tests. The showed most consistent found Stroop (where 42% demonstrated significant abnormalities). sensitive auditory/verbal memory: delayed recognition (83%); evoked potentials (60%); visual/spatial (50%); sustained attention (47%). Attention tasks not particularly (impairments 0%–47% studies). level-response relationship was ( p = 0.001), well three executive domain: inhibition 0.034), reasoning/association 0.019), working memory 0.024). shows higher more severe hypoxia, predominantly below 80% No influence barometric pressure could be identified limited number where this varied. review suggests complex functions hypoxia. Moreover, first step towards standardization testing, crucial better understanding cognition.

Язык: Английский

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Cognitive Effects of Repeated Acute Exposure to Very High Altitude Among Altitude-Experienced Workers at 5050 m

High Altitude Medicine & Biology, Год журнала: 2019, Номер 20(4), С. 361 - 374

Опубликована: Окт. 25, 2019

Background: We investigated altitude effects on different cognitive domains among perennial shift-workers at the Atacama Large Millimeter/submillimeter Array Observatory (5050 m), Chile. Materials and Methods: Twenty healthy male workers were recruited assigned to either a moderate-altitude first (MAF group, Test 1: 2900 m 2: 5050 m) or high-altitude (HAF m). 1 was conducted beginning 2 end of shift-work week. Processing speed (RTI, reaction time), attention (AST, attention-switching task, RVP, rapid visual processing), executive function (OTS, One Touch Stockings Cambridge) assessed. Results: Of three assessed, only processing showed altitude-at-test group interaction (RTI median five choice time: F1, 17 = 6.980, [Formula: see text] 0.291, p 0.017). With acclimatization, there decrease in AST latency mean (t17 -2.155, dz 1.086, 0.046), an increase RVP accuracy 2.733, 1.398, 0.014), OTS -2.375, 1.211, 0.03). Decreased variability observed standard deviation -2.524, 1.282, 0.022) response -2.35, 1.177, 0.03) with acclimatization. At elevation, SpO2 positively correlated MAF (OTS problems solved choice: r(5) 0.839, 0.018) negatively deviations HAF deviation: r(10) -0.618, 0.032). Conclusions: Our findings highlight importance acclimatization improvement blood oxygen level, even high altitude-experienced workers, optimize performance cognitively demanding work reduce altitude-associated health risks.

Язык: Английский

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Exercise-Induced Elevated BDNF Concentration Seems to Prevent Cognitive Impairment after Acute Exposure to Moderate Normobaric Hypoxia among Young Men

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(4), С. 3629 - 3629

Опубликована: Фев. 18, 2023

Memory impairment, reduced learning ability, decreased concentration, and psychomotor performance can be all signs of deleterious impact hypoxia on cognitive functioning. In turn, physical exercise improve enhance functions. The purpose this study was to investigate whether the potential positive effects performed under normobaric counteract negative function, these changes correlate with brain-derived neurotrophic factor (BDNF) concentrations. Seventeen healthy subjects participated in a crossover where they two sessions single breathing bouts combined moderate intensity conditions: normoxia (NOR EX) (NH EX). To assess Stroop test applied. There were no significant differences any part interference regardless conditions (NOR, NH), despite statistical decrease SpO

Язык: Английский

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Effect of Acute Normobaric Hypoxia Exposure on Executive Functions among Young Physically Active Males

Journal of Clinical Medicine, Год журнала: 2021, Номер 10(8), С. 1560 - 1560

Опубликована: Апрель 8, 2021

Background: On the one hand, hypoxic exposure may result in progressive brain metabolism disturbance, causing subsequent cognitive impairments. other it might also enhance neurogenesis and vascularization as well accelerate cerebral blood flow, leading to function improvement. The aim of this study was investigate whether stages normobaric hypoxia (NH) (FIO2 = 13%, FIO2 12%, 11%) differentially affect post-exposure performance. Methods: Fifteen physically active men (age 23.1 ± 2.1) participated study. Stroop test (ST) applied assess function. To generate NH conditions, a air generator used. Results: We observed an executive impairment (“naming” interference p < 0.05) after 13%). After at 12% 11%, no changes were test. Also, SpO2 during observed. Conclusions: current investigation shows that functions deteriorate acute deterioration is not proportional among young males.

Язык: Английский

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