Journal of Psychopharmacology,
Год журнала:
2022,
Номер
37(1), С. 14 - 32
Опубликована: Дек. 17, 2022
Ketamine
is
an
N-methyl-d-aspartate
antagonist
which
increasingly
being
researched
and
used
as
a
treatment
for
depression.
In
low
doses,
it
can
cause
transitory
modification
in
consciousness
was
classically
labelled
‘dissociation’.
However,
ketamine
also
commonly
classified
atypical
psychedelic
has
been
recently
reported
that
ego
dissolution
experiences
during
administration
are
associated
with
greater
antidepressant
response.
Neuroimaging
studies
have
highlighted
several
similarities
between
the
effects
of
those
serotonergic
psychedelics
brain;
however,
no
unified
account
proposed
ketamine’s
multi-level
–
from
molecular
to
network
psychological
levels.
Here,
we
propose
fast,
albeit
transient,
observed
after
infusions
mainly
driven
by
its
acute
modulation
reward
circuits
sub-acute
increase
neuroplasticity,
while
dissociative
properties
dose-
context-dependent
disruption
large-scale
functional
networks.
Computationally,
nodes
salience
(SN)
represent
high-level
priors
about
body
(‘minimal’
self)
default-mode
(DMN)
highest-level
narrative
self-experience
(‘biographical’
self),
SN
desegregation
disintegration
accounts
‘
dissociative’
state,
DMN
psychedelic’
state.
psychedelic-assisted
psychotherapy,
relaxation
beliefs
psychotherapeutic
support
may
allow
revision
pathological
self-representation
models,
neuroplasticity
plays
permissive
role.
Our
provides
rationale
using
long-term
benefits.
Frontiers in Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Май 23, 2023
Psilocybin,
a
naturally
occurring
hallucinogenic
component
of
magic
mushrooms,
has
significant
psychoactive
effects
in
both
humans
and
rodents.
But
the
underlying
mechanisms
are
not
fully
understood.
Blood-oxygenation
level-dependent
(BOLD)
functional
magnetic
resonance
imaging
(fMRI)
is
useful
tool
many
preclinical
clinical
trials
to
investigate
psilocybin-induced
changes
brain
activity
connectivity
(FC)
due
its
noninvasive
nature
widespread
availability.
However,
fMRI
psilocybin
on
rats
have
been
carefully
investigated.
This
study
aimed
explore
how
affects
resting-state
FC,
through
combination
BOLD
immunofluorescence
(IF)
EGR1,
an
immediate
early
gene
(IEG)
closely
related
depressive
symptoms.
Ten
minutes
after
hydrochloride
injection
(2.0
mg/kg,
i.p.),
positive
activities
were
observed
frontal,
temporal,
parietal
cortex
(including
cingulate
retrosplenial
cortex),
hippocampus,
striatum.
And
region-of-interest
(ROI)
-wise
FC
analysis
matrix
suggested
increased
interconnectivity
several
regions,
such
as
cortex,
dorsal
striatum,
prelimbic,
limbic
regions.
Further
seed-based
analyses
revealed
within
cortical
striatal
areas.
Consistently,
acute
EGR1
level
throughout
brain,
indicating
consistent
activation
thought
In
conclusion,
hyperactive
state
congruent
that
humans,
may
be
responsible
for
pharmacological
effects.
Entropy,
Год журнала:
2024,
Номер
26(1), С. 90 - 90
Опубликована: Янв. 22, 2024
We
explore
the
intersection
of
neural
dynamics
and
effects
psychedelics
in
light
distinct
timescales
a
framework
integrating
concepts
from
dynamics,
complexity,
plasticity.
call
this
geometrodynamics
for
its
parallels
with
general
relativity’s
description
interplay
spacetime
matter.
The
geometry
trajectories
within
dynamical
landscape
“fast
time”
are
shaped
by
structure
differential
equation
connectivity
parameters,
which
themselves
evolve
over
“slow
driven
state-dependent
state-independent
plasticity
mechanisms.
Finally,
adjustment
processes
(metaplasticity)
takes
place
an
“ultraslow”
time
scale.
Psychedelics
flatten
landscape,
leading
to
heightened
entropy
complexity
as
observed
neuroimaging
modeling
studies
linking
increases
disruption
functional
integration.
highlight
relationship
between
criticality,
fast
synaptic
Pathological,
rigid,
or
“canalized”
result
ultrastable
confined
repertoire,
allowing
slower
plastic
changes
consolidate
them
further.
However,
under
influence
psychedelics,
destabilizing
emergence
complex
leads
more
fluid
adaptable
state
process
that
is
amplified
plasticity-enhancing
psychedelics.
This
shift
manifests
acute
systemic
increase
disorder
possibly
longer-lasting
affecting
both
short-term
long-term
processes.
Our
offers
holistic
perspective
on
these
substances
their
potential
impacts
function.
Trends in Neurosciences,
Год журнала:
2024,
Номер
47(7), С. 551 - 568
Опубликована: Май 31, 2024
Disentangling
how
cognitive
functions
emerge
from
the
interplay
of
brain
dynamics
and
network
architecture
is
among
major
challenges
that
neuroscientists
face.
Pharmacological
pathological
perturbations
consciousness
provide
a
lens
to
investigate
these
complex
challenges.
Here,
we
review
recent
advances
about
brain's
functional
organisation
have
been
driven
by
common
denominator:
decomposing
function
into
fundamental
constituents
time,
space,
information.
Whereas
unconsciousness
increases
structure-function
coupling
across
scales,
psychedelics
may
decouple
structure.
Convergent
effects
also
emerge:
anaesthetics,
psychedelics,
disorders
can
exhibit
similar
reconfigurations
unimodal-transmodal
axis.
Decomposition
approaches
reveal
potential
translate
discoveries
species,
with
computational
modelling
providing
path
towards
mechanistic
integration.
Biological Psychiatry Global Open Science,
Год журнала:
2024,
Номер
4(6), С. 100372 - 100372
Опубликована: Авг. 9, 2024
Short
mindfulness-based
interventions
have
gained
traction
in
research
due
to
their
positive
impact
on
well-being,
cognition,
and
clinical
symptoms
across
various
settings.
However,
these
short-term
trainings
are
viewed
as
preliminary
steps
within
a
more
extensive
transformative
path,
presumably
leading
long-lasting
trait
changes.
Despite
this,
little
is
still
known
about
the
brain
correlates
of
meditation
traits.
Journal of Psychopharmacology,
Год журнала:
2022,
Номер
37(1), С. 14 - 32
Опубликована: Дек. 17, 2022
Ketamine
is
an
N-methyl-d-aspartate
antagonist
which
increasingly
being
researched
and
used
as
a
treatment
for
depression.
In
low
doses,
it
can
cause
transitory
modification
in
consciousness
was
classically
labelled
‘dissociation’.
However,
ketamine
also
commonly
classified
atypical
psychedelic
has
been
recently
reported
that
ego
dissolution
experiences
during
administration
are
associated
with
greater
antidepressant
response.
Neuroimaging
studies
have
highlighted
several
similarities
between
the
effects
of
those
serotonergic
psychedelics
brain;
however,
no
unified
account
proposed
ketamine’s
multi-level
–
from
molecular
to
network
psychological
levels.
Here,
we
propose
fast,
albeit
transient,
observed
after
infusions
mainly
driven
by
its
acute
modulation
reward
circuits
sub-acute
increase
neuroplasticity,
while
dissociative
properties
dose-
context-dependent
disruption
large-scale
functional
networks.
Computationally,
nodes
salience
(SN)
represent
high-level
priors
about
body
(‘minimal’
self)
default-mode
(DMN)
highest-level
narrative
self-experience
(‘biographical’
self),
SN
desegregation
disintegration
accounts
‘
dissociative’
state,
DMN
psychedelic’
state.
psychedelic-assisted
psychotherapy,
relaxation
beliefs
psychotherapeutic
support
may
allow
revision
pathological
self-representation
models,
neuroplasticity
plays
permissive
role.
Our
provides
rationale
using
long-term
benefits.
