The impact of gamma transcranial alternating current stimulation (tACS) on cognitive and memory processes in patients with mild cognitive impairment or Alzheimer's disease: A literature review

Brain stimulation, Год журнала: 2023, Номер 16(3), С. 748 - 755

Опубликована: Апрель 5, 2023

Highlights•40 Hz tACS enhances gamma oscillations and memory performance in MCI/AD patients.•Active 40 increases spectral power patients over sham.•Gamma stimulation may aid clearance of tau mouse models AD patients.AbstractBackgroundTranscranial alternating current (tACS)—a noninvasive brain technique that modulates cortical through entrainment—has been demonstrated to alter oscillatory activity enhance cognition healthy adults. TACS is being explored as a tool improve patient populations with mild cognitive impairment (MCI) Alzheimer's disease (AD).ObjectiveTo review the growing body literature findings obtained from application MCI or AD, highlighting effects on function, memory, cognition. Evidence use animal also discussed. Important parameters are underscored for consideration protocols aim apply therapeutic MCI/AD.FindingsThe has shown promising results improvement processes impacted MCI/AD. These data demonstrate potential an interventional stand-alone alongside pharmacological and/or other behavioral interventions MCI/AD.ConclusionsWhile evidenced encouraging results, this function pathophysiology remains be fully determined. This explores highlights need continued research course by reinstating activity, improving processing, delaying progression, remediating abilities

Язык: Английский

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Theta activity and cognitive functioning: Integrating evidence from resting-state and task-related developmental electroencephalography (EEG) research

Developmental Cognitive Neuroscience, Год журнала: 2024, Номер 67, С. 101404 - 101404

Опубликована: Июнь 1, 2024

The theta band is one of the most prominent frequency bands in electroencephalography (EEG) power spectrum and presents an interesting paradox: while elevated during resting state linked to lower cognitive abilities children adolescents, increased tasks associated with higher performance. Why does power, measured versus tasks, show differential correlations functioning? This review provides integrated account functional correlates across different contexts. We first present evidence that correlated executive functioning, attentional abilities, language skills, IQ. Next, we research showing increases memory, attention, control, these processes better Finally, discuss potential explanations for between resting/task-related offer suggestions future this area.

Язык: Английский

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Advances in Non-Invasive Neuromodulation Techniques for Improving Cognitive Function: A Review

Brain Sciences, Год журнала: 2024, Номер 14(4), С. 354 - 354

Опубликована: Апрель 1, 2024

Non-invasive neuromodulation techniques are widely utilized to study and improve cognitive function, with the aim of modulating different processes. For workers performing high-intensity mental physical tasks, extreme fatigue may not only affect their working efficiency but also lead decline or impairment, which, in turn, poses a serious threat health. The use non-invasive has important research value for improving enhancing function. In this paper, we review status, existing problems, future prospects transcranial direct current stimulation (tDCS), alternating (tACS), magnetic (TMS), transcutaneous acupoint (TAS), which most studied methods enhance cognition. findings presented paper will be great reference in-depth field

Язык: Английский

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The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial

Trials, Год журнала: 2024, Номер 25(1)

Опубликована: Фев. 23, 2024

Abstract Background The ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia mild cognitive impairment (MCI). latter can be considered a prodromal phase some dementias critical stage for interventions to postpone functionality. Working memory (WM) is pivotal function, representing fundamental element executive functions. This project proposes an intervention protocol enhance WM in these users, combining training with transcranial electrical stimulation alternating current (tACS). technique been suggested neuronal plasticity needed processes involving oscillatory patterns. stands benefit significantly from this approach, given its well-defined electrophysiological oscillations. Therefore, tACS could potentially boost patients neurodegenerative diseases. Methods study IIb randomised, double-blind clinical trial 3-month follow-up period. participants will 62 diagnosed MCI, aged over 60, Valparaíso, Chile. Participants receive twelve sessions tACS. either or placebo eight out sessions. Sessions occur twice weekly 6 weeks. primary outcomes electroencephalographic measurements through prefrontal theta activity, while secondary effects assessments WM. evaluated before, immediately after, 3 months after end intervention. Discussion add empirical evidence about benefits feasibility that combines non-invasive brain stimulation. objective contribute tools optimal treatment MCI. To capacity, functionality, obtain better quality life. Trial registration ClinicalTrials.gov NCT05291208. Registered on 28 February 2022. ISRCTN87597719 retrospectively registered 15 September 2023.

Язык: Английский

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Intermittent theta burst stimulation with synchronised transcranial alternating current stimulation leads to enhanced frontal theta oscillations and a positive shift in emotional bias

Imaging Neuroscience, Год журнала: 2024, Номер 2, С. 1 - 14

Опубликована: Янв. 1, 2024

Abstract Repetitive transcranial magnetic stimulation (rTMS), delivered to left dorsolateral prefrontal cortex, is an FDA-approved, and NICE-recommended, neuromodulation therapy for major depressive disorder (MDD). However, there considerable inter-individual variability in rate extent of clinical response, leading a focus on approaches optimising its effectiveness. We present findings from non-patient study evaluating approach that combines efficient type rTMS—“intermittent theta burst stimulation” (iTBS)—with second technique—“transcranial alternating current (tACS). tACS synchrony with the iTBS intent brain state during stimulation. In four separate sessions, we 3 minutes iTBS+tACS, iTBS+sham, sham+tACS, or double sham. measured changes pre- post-stimulation (4–8 Hz) oscillatory activity using electroencephalography, emotional bias well-studied emotion identification task. Theta has previously shown relationships response rTMS, been proposed as marker potential antidepressant efficacy. found frontal power was enhanced following dual therapy, building up over 15-minute period exceed either technique alone Emotional bias, 20 post-stimulation, also significantly more positive therapy. These indicate tACS-synchronised (tsiTBS) holds promise augmentation which awaits validation multi-session patient studies.

Язык: Английский

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Transcranial alternating current stimulation barely enhances working memory in healthy adults: A meta-analysis

Brain Research, Год журнала: 2024, Номер 1839, С. 149022 - 149022

Опубликована: Май 25, 2024

Язык: Английский

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The effects of gamma-tACS on cognitive impairment in multiple sclerosis: A randomized, double-blind, sham-controlled, pilot study

Multiple Sclerosis Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Background: Multiple sclerosis (MS) often causes impairment in working memory (WM), information processing speed (IPS), and verbal (VM). These deficits are linked to disrupted neural oscillatory activity. Transcranial alternating current stimulation (tACS), which modulates cortical oscillations, may hold promise for treating cognitive MS. Objectives: To evaluate online offline effects of gamma (γ)-tACS on WM, IPS, VM while assessing changes brain rhythms using electroencephalography (EEG). Methods: Thirty-six MS patients with single-domain WM (12), IPS (13), or (11) underwent γ-tACS sham-tACS over the left dorsolateral prefrontal cortex (DLPFC) (WM, IPS) precuneus Cognitive performance was assessed pre-tACS (T0), during (T1), post-tACS (T2) Digit Span Backward (DSBW) Symbol Modalities Test (SDMT) Rey Auditory Verbal Learning (RAVLT) VM. EEG recorded at T0 T2 analyze local power spectral density local-to-global connectivity. Results: DSBW, SDMT, RAVLT scores transiently improved not sham. IPS-impaired showed a reduction across all frequency bands, site, post-DLPFC γ-tACS. Conclusion: briefly improves patients, warranting further trials this non-invasive intervention.

Язык: Английский

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Triangular Wave tACS Improves Working Memory Performance by Enhancing Brain Activity in the Early Stage of Encoding

Neuroscience Bulletin, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Язык: Английский

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Efficacy of transcranial alternating current stimulation for schizophrenia treatment: A systematic review

Journal of Psychiatric Research, Год журнала: 2023, Номер 168, С. 52 - 63

Опубликована: Окт. 19, 2023

Язык: Английский

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Transcranial alternating current stimulation in affecting cognitive impairment in psychiatric disorders: a review

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2023, Номер 274(4), С. 803 - 826

Опубликована: Сен. 8, 2023

Transcranial alternating current stimulation (tACS) is a non-invasive brain method that, through its manipulation of endogenous oscillations, can affect cognition in healthy adults. Given the fact that both oscillations and are impaired various psychiatric diagnoses, tACS might represent suitable intervention. We conducted search Pubmed Web Science databases reviewed 27 studies where used diagnoses change evaluated. TACS safe well-tolerated intervention method, for multiple-sessions protocols. It be administered at home, individualized according to patient''s anatomical functional characteristics, or as marker disease progression. The results varying across applied protocols, with some protocols showing long-term effect. However, overall number small great variety parameters, such electrode montage frequency. Precise mechanisms interaction pathophysiological processes only partially described need further research. Currently, seems feasible alleviate cognitive impairment patients; however, more robust confirmation efficacy potential needed introduce it into clinical practise.

Язык: Английский

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