Nature Communications,
Год журнала:
2017,
Номер
8(1)
Опубликована: Ноя. 15, 2017
Upon
mating,
fruit
fly
females
become
refractory
to
further
mating
for
several
days.
An
ejaculate
protein
called
sex
peptide
(SP)
acts
on
uterine
neurons
trigger
this
behavioural
change,
but
it
is
still
unclear
how
the
SP
signal
modifies
decision.
Here
we
describe
two
groups
of
female-specific
local
interneurons
that
are
important
process-the
ventral
abdominal
lateral
(vAL)
and
medial
(vAM)
interneurons.
Both
vAL
vAM
express
myoinhibitory
(Mip)-GAL4.
positive
Mip
neuropeptides
sex-determining
transcriptional
factor
doublesex.
Silencing
in
induces
active
rejection
male
courtship
attempts,
whereas
activation
makes
even
mated
receptive
re-mating.
located
ganglion
(AG)
where
they
relay
other
AG
project
brain.
appear
promote
receptivity
both
virgins
females,
although
dispensable
normal
virgin
females.
The
neural
circuits
responsible
for
animal
behavior
remain
largely
unknown.
We
summarize
new
methods
and
present
the
circuitry
of
a
large
fraction
brain
fruit
fly
Drosophila
melanogaster
.
Improved
include
procedures
to
prepare,
image,
align,
segment,
find
synapses
in,
proofread
such
data
sets.
define
cell
types,
refine
computational
compartments,
provide
an
exhaustive
atlas
examples
many
them
novel.
detailed
consisting
neurons
their
chemical
most
central
brain.
make
public
simplify
access,
reducing
effort
needed
answer
circuit
questions,
linking
defined
by
our
analysis
with
genetic
reagents.
Biologically,
we
examine
distributions
connection
strengths,
motifs
on
different
scales,
electrical
consequences
compartmentalization,
evidence
that
maximizing
packing
density
is
important
criterion
in
evolution
fly’s
Cell,
Год журнала:
2023,
Номер
186(12), С. 2556 - 2573.e22
Опубликована: Май 25, 2023
In
Drosophila,
a
dedicated
olfactory
channel
senses
male
pheromone,
cis-vaccenyl
acetate
(cVA),
promoting
female
courtship
while
repelling
males.
Here,
we
show
that
separate
cVA-processing
streams
extract
qualitative
and
positional
information.
cVA
sensory
neurons
respond
to
concentration
differences
in
5-mm
range
around
male.
Second-order
projection
encode
the
angular
position
of
by
detecting
inter-antennal
concentration,
which
are
amplified
through
contralateral
inhibition.
At
third
circuit
layer,
identify
47
cell
types
with
diverse
input-output
connectivity.
One
population
responds
tonically
flies,
second
is
tuned
looming,
integrates
taste
coincidentally
promote
mating.
The
separation
features
resembles
mammalian
what
where
visual
streams;
together
multisensory
integration,
this
enables
behavioral
responses
appropriate
specific
ethological
contexts.
Aggressive
social
interactions
are
used
to
compete
for
limited
resources
and
regulated
by
complex
sensory
cues
the
organism's
internal
state.
While
both
sexes
exhibit
aggression,
its
neuronal
underpinnings
understudied
in
females.
Here,
we
identify
a
population
of
sexually
dimorphic
aIPg
neurons
adult
Drosophila
melanogaster
central
brain
whose
optogenetic
activation
increased,
genetic
inactivation
reduced,
female
aggression.
Analysis
GAL4
lines
identified
an
unbiased
screen
increased
chasing
behavior
revealed
involvement
another
neuron,
pC1d,
implicated
pC1d
as
core
nodes
regulating
Connectomic
analysis
demonstrated
that
interconnected
suggest
may
exert
part
their
effect
gating
flow
visual
information
descending
neurons.
Our
work
reveals
important
regulatory
components
circuitry
underlies
aggressive
provides
tools
manipulation.
Briefings in Functional Genomics,
Год журнала:
2015,
Номер
14(6), С. 396 - 406
Опубликована: Март 22, 2015
In
recent
years,
our
knowledge
of
the
conserved
master-switch
gene
doublesex
(dsx)
and
its
function
in
regulating
development
dimorphic
traits
insects
has
deepened
considerably.
Here,
a
comprehensive
overview
is
given
on
properties
male-
female-specific
dsx
transcripts
yielding
DSXF
DSXM
proteins
Drosophila
melanogaster,
many
downstream
targets
that
they
regulate.
As
have
cell-autonomous
sex
determination,
it
was
assumed
would
be
expressed
every
somatic
cell,
but
research
showed
only
when
cell
required
to
show
sexual
identity
through
or
morphology.
This
spatiotemporal
regulation
expression
not
been
established
D.
melanogaster
all
insect
species
studied.
Gradually,
appreciated
could
no
longer
viewed
as
orchestrating
behaviour
each
instead
should
interpreter
for
expressing
this
request,
making
central
nexus
determination.
