Current Opinion in Neurobiology, Год журнала: 2017, Номер 46, С. 200 - 207
Опубликована: Сен. 20, 2017
Язык: Английский
Current Opinion in Neurobiology, Год журнала: 2017, Номер 46, С. 200 - 207
Опубликована: Сен. 20, 2017
Язык: Английский
Nature Communications, Год журнала: 2016, Номер 7(1)
Опубликована: Ноя. 8, 2016
Abstract Rapid variations in cortical state during wakefulness have a strong influence on neural and behavioural responses are tightly coupled to changes pupil size across species. However, the physiological processes linking largely unknown. Here we demonstrate that these rapid variations, both quiet waking locomotion, highly correlated with fluctuations activity of corticopetal noradrenergic cholinergic projections. dilations associated phasic axons, whereas longer-lasting pupil, such as accompanied by sustained axons. Thus, can be used sensitively track multiple neuromodulatory transmitter systems they control brain.
Язык: Английский
Процитировано
867Neuron, Год журнала: 2016, Номер 91(6), С. 1199 - 1218
Опубликована: Сен. 1, 2016
Recent work continues to place cholinergic circuits at center stage for normal executive and mnemonic functioning provides compelling evidence that the loss of signaling cognitive decline are inextricably linked. This Review focuses on last few years studies mechanisms by which contributes circuit activity related cognition. We attempt identify areas controversy, as well consensus, what is not yet known about how in CNS processes. In addition, we delineate findings from recent extent dysfunction associated with neurodegenerative disorders.
Язык: Английский
Процитировано
642Trends in Cognitive Sciences, Год журнала: 2020, Номер 24(6), С. 466 - 480
Опубликована: Апрель 21, 2020
Язык: Английский
Процитировано
467Science, Год журнала: 2017, Номер 355(6328), С. 954 - 959
Опубликована: Март 2, 2017
γ-Aminobutyric acid (GABA)ergic inputs are strategically positioned to gate synaptic integration along the dendritic arbor of pyramidal cells. However, their spatiotemporal dynamics during behavior poorly understood. Using an optical-tagging electrophysiological approach record and label somatostatin-expressing (Sst) interneurons (GABAergic neurons specialized for inhibition), we discovered a layer-specific modulation activity in behaving mice. Sst interneuron subtypes, residing different cortical layers innervating complementary laminar domains, exhibited opposite changes transitions active wakefulness. The relative weight vasoactive intestinal peptide-expressing (Vip) interneuron-mediated inhibition distinct cholinergic determined vivo activity. These results reveal state-dependent influence inhibition, with implications compartmentalized regulation signaling mammalian neocortex.
Язык: Английский
Процитировано
307Trends in Neurosciences, Год журнала: 2016, Номер 40(3), С. 181 - 193
Опубликована: Дек. 22, 2016
Язык: Английский
Процитировано
256Nature, Год журнала: 2018, Номер 561(7723), С. 391 - 395
Опубликована: Сен. 1, 2018
Язык: Английский
Процитировано
255Annual Review of Neuroscience, Год журнала: 2020, Номер 43(1), С. 391 - 415
Опубликована: Апрель 6, 2020
Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans animals reveal that these variations not random their nature, but may fact be due large part to rapid shifts neural, cognitive, behavioral states. Here we review recent advances the understanding waking state, how generated, they modulate neural mice humans. We propose brain has an identifiable set states through which it wanders continuously a nonrandom fashion, owing ascending modulatory fast-acting corticocortical subcortical-cortical pathways. These state provide backdrop upon operates, them is critical making progress revealing mechanisms underlying cognition behavior.
Язык: Английский
Процитировано
253Frontiers in Neural Circuits, Год журнала: 2018, Номер 12
Опубликована: Март 8, 2018
Pupillometry has long been used as a measure of brain state. Changes in pupil diameter are thought to coincide with the activity neuromodulators, including noradrenaline and acetylcholine, producing alterations state corresponding changes behavior. Here we review mechanisms underlying control how these correlated cortical recruitment neuromodulatory circuits.
Язык: Английский
Процитировано
251Nature Neuroscience, Год журнала: 2016, Номер 19(12), С. 1733 - 1742
Опубликована: Окт. 17, 2016
Язык: Английский
Процитировано
249Cell Reports, Год журнала: 2017, Номер 18(7), С. 1817 - 1830
Опубликована: Фев. 1, 2017
Basal forebrain cholinergic neurons influence cortical state, plasticity, learning, and attention. They collectively innervate the entire cerebral cortex, differentially controlling acetylcholine efflux across different areas timescales. Such control might be achieved by differential inputs driving separable outputs, although no input-output relationship on a brain-wide level has ever been demonstrated. Here, we identify input to cells projecting specific regions infecting axon terminals with monosynaptically restricted viral tracer. This approach revealed several circuit motifs, such as central amygdala synapsing onto basolateral amygdala-projecting or strong somatosensory motor cortex-projecting neurons. The presence of in parasympathetic midbrain nuclei contacting frontally suggest that network regulating inner eye muscles are additionally state via efflux. dataset enables future circuit-level experiments drivers known functions.
Язык: Английский
Процитировано
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