Cortical-subcortical interactions in goal-directed behavior DOI
K. Guadalupe Cruz,

Yi Ning Leow,

Nhat Minh Le

и другие.

Physiological Reviews, Год журнала: 2022, Номер 103(1), С. 347 - 389

Опубликована: Июнь 30, 2022

Flexibly selecting appropriate actions in response to complex, ever-changing environments requires both cortical and subcortical regions, which are typically described as participating a strict hierarchy. In this traditional view, highly specialized circuits allow for efficient responses salient stimuli, at the cost of adaptability context specificity, attributed neocortex. Their interactions often cortex providing top-down command signals structures implement; however, available technologies develop, studies increasingly demonstrate that behavior is represented by brainwide activity even contain early choice, suggesting behavioral functions emerge result different regions interacting truly collaborative networks. review, we discuss field’s evolving understanding how placental mammals interact cooperatively, not only via cortical-subcortical inputs but through bottom-up interactions, especially thalamus. We describe our current circuitry two exemplar structures, superior colliculus striatum, identify information prioritized regions. then functional these form with one another, thalamus, create parallel loops complex networks flow. Finally, challenge classic view modules contained within specific brain regions; instead, propose certain prioritize types over others, subnetworks they form, defined their anatomical connections dynamics, basis true specialization.

Язык: Английский

Thalamic regulation of switching between cortical representations enables cognitive flexibility DOI
Rajeev Rikhye, Aditya Gilra, Michael M. Halassa

и другие.

Nature Neuroscience, Год журнала: 2018, Номер 21(12), С. 1753 - 1763

Опубликована: Ноя. 8, 2018

Язык: Английский

Процитировано

273
Thalamocortical Circuit Motifs: A General Framework DOI Creative Commons
Michael M. Halassa, S. Murray Sherman

Neuron, Год журнала: 2019, Номер 103(5), С. 762 - 770

Опубликована: Сен. 1, 2019

Язык: Английский

Процитировано

271
The impact of the human thalamus on brain-wide information processing DOI
James M. Shine, Laura D. Lewis, Douglas D. Garrett

и другие.

Nature reviews. Neuroscience, Год журнала: 2023, Номер 24(7), С. 416 - 430

Опубликована: Май 26, 2023

Язык: Английский

Процитировано

131
Mechanisms of distributed working memory in a large-scale network of macaque neocortex DOI Creative Commons
Jorge F. Mejías, Xiao‐Jing Wang

eLife, Год журнала: 2022, Номер 11

Опубликована: Фев. 24, 2022

Neural activity underlying working memory is not a local phenomenon but distributed across multiple brain regions. To elucidate the circuit mechanism of such activity, we developed an anatomically constrained computational model large-scale macaque cortex. We found that mnemonic internal states may emerge from inter-areal reverberation, even in regime where none isolated areas capable generating self-sustained activity. The pattern along cortical hierarchy indicates transition space, separating engaged and those which do not. A host spatially distinct attractor found, potentially subserving various processes. yields testable predictions, including idea counterstream inhibitory bias, role prefrontal controlling attractors, resilience to lesions or inactivation. This work provides theoretical framework for identifying mechanisms principles cognitive

Язык: Английский

Процитировано

109
The mediodorsal thalamus in executive control DOI
Mathieu Wolff, Michael M. Halassa

Neuron, Год журнала: 2024, Номер 112(6), С. 893 - 908

Опубликована: Янв. 30, 2024

Язык: Английский

Процитировано

23
Principles of Corticocortical Communication: Proposed Schemes and Design Considerations DOI
Adam Kohn,

Anna I. Jasper,

João D. Semedo

и другие.

Trends in Neurosciences, Год журнала: 2020, Номер 43(9), С. 725 - 737

Опубликована: Авг. 5, 2020

Язык: Английский

Процитировано

91
Visual intracortical and transthalamic pathways carry distinct information to cortical areas DOI Creative Commons
Antonin Blot, Morgane Roth,

Ioana T. Gasler

и другие.

Neuron, Год журнала: 2021, Номер 109(12), С. 1996 - 2008.e6

Опубликована: Май 11, 2021

Sensory processing involves information flow between neocortical areas, assumed to rely on direct intracortical projections. However, cortical areas may also communicate indirectly via higher-order nuclei in the thalamus, such as pulvinar or lateral posterior nucleus (LP) visual system of rodents. The fine-scale organization and function these cortico-thalamo-cortical pathways remains unclear. We find that responses mouse LP neurons projecting higher likely derive from feedforward input primary cortex (V1) combined with many subcortical including superior colliculus. Signals projections different are tuned specific features stimuli their locomotor context, distinct signals carried by V1. Thus, transthalamic functionally target, pathways, combine multiple brain regions, linking sensory behavioral context.

Язык: Английский

Процитировано

90
Context-dependent and dynamic functional influence of corticothalamic pathways to first- and higher-order visual thalamus DOI Open Access
Megan A. Kirchgessner, Alexis D. Franklin, Edward M. Callaway

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2020, Номер 117(23), С. 13066 - 13077

Опубликована: Май 27, 2020

Layer 6 (L6) is the sole purveyor of corticothalamic (CT) feedback to first-order thalamus and also sends projections higher-order thalamus, yet how it engages full circuit contribute sensory processing in an awake animal remains unknown. We sought elucidate functional impact L6CT from primary visual cortex dorsolateral geniculate nucleus (first-order) pulvinar (higher-order) using optogenetics extracellular electrophysiology mice. While sustained photostimulation suppresses activity both thalamic nuclei vivo, moderate-frequency (10 Hz) stimulation powerfully facilitates spiking. show that each paradigm differentially influences balance between monosynaptic excitatory disynaptic inhibitory pathways pulvinar, as well prevalence burst versus tonic firing. Altogether, our results support a model which L6CTs modulate first- through parallel are highly dynamic context-dependent.

Язык: Английский

Процитировано

89
A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex DOI Creative Commons
Seán Froudist‐Walsh,

Daniel P. Bliss,

Xingyu Ding

и другие.

Neuron, Год журнала: 2021, Номер 109(21), С. 3500 - 3520.e13

Опубликована: Сен. 17, 2021

Dopamine is required for working memory, but how it modulates the large-scale cortex unknown. Here, we report that dopamine receptor density per neuron, measured by autoradiography, displays a macroscopic gradient along macaque cortical hierarchy. This incorporated in connectome-based model endowed with multiple neuron types. The captures an inverted U-shaped dependence of memory on and spatial patterns persistent activity observed over 90 experimental studies. Moreover, show crucial filtering out irrelevant stimuli enhancing inhibition from dendrite-targeting interneurons. Our revealed activity-silent trace can be realized facilitation inter-areal connections adjusting induces switch this internal state to distributed activity. work represents cross-level understanding molecules cell types recurrent circuit dynamics underlying core cognitive function across primate cortex.

Язык: Английский

Процитировано

88
Thalamocortical excitability modulation guides human perception under uncertainty DOI Creative Commons
Julian Q. Kosciessa, Ulman Lindenberger, Douglas D. Garrett

и другие.

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Апрель 23, 2021

Abstract Knowledge about the relevance of environmental features can guide stimulus processing. However, it remains unclear how processing is adjusted when feature uncertain. We hypothesized that (a) heightened uncertainty would shift cortical networks from a rhythmic, selective processing-oriented state toward an asynchronous (“excited”) boosts sensitivity to all features, and (b) thalamus provides subcortical nexus for such uncertainty-related shifts. Here, we had young adults attend varying numbers task-relevant during EEG fMRI acquisition test these hypotheses. Behavioral modeling electrophysiological signatures revealed greater lowered rate evidence accumulation individual shifted cortex rhythmic asynchronous/excited regime, neuromodulatory arousal. Crucially, this unified constellation within-person effects was dominantly reflected in uncertainty-driven upregulation thalamic activity. argue processes involving play central role brain modulates neural excitability face momentary uncertainty.

Язык: Английский

Процитировано

85