Disruption of transthalamic circuitry from primary visual cortex impairs visual discrimination in mice DOI Creative Commons

C. McKinnon,

Christina Mo, S. Murray Sherman

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

ABSTRACT Layer 5 (L5) of the cortex provides strong driving input to higher-order thalamic nuclei, such as pulvinar in visual system, forming basis cortico-thalamo-cortical (transthalamic) circuits. These circuits provide a communication route between cortical areas parallel direct corticocortical connections, but their specific role perception and behavior remains unclear. Using targeted optogenetic inhibition mice performing discrimination task, we selectively suppressed corticothalamic from L5 cells primary (V1) at terminals pulvinar. This suppresses transthalamic V1; furthermore, any effect on projections local V1 circuitry would thus result inputs (e.g., back (Miller-Hansen Sherman, 2022). Such suppression processing during stimulus presentation drifting gratings significantly impaired performance across different orientations. The impact was portion space that retinotopically coincided with inhibition. results highlight importance incorporating L5-initiated into frameworks, particularly those addressing how hierarchical propagation sensory signals supports perceptual decision-making. SIGNIFICANCE STATEMENT Appreciation pathways for areas, organized has transformed our thinking about functioning writ large. Studies initially concentrated anatomy physiology, there been shift towards understanding cognitive behavior. Here, have used an approach inhibit pathway other itself. We find degrades animals’ ability discriminate, showing first time reduces discrimination. causal data adds growing evidence signaling processing.

Язык: Английский

Untangling the cortico-thalamo-cortical loop: cellular pieces of a knotty circuit puzzle DOI
Gordon M. Shepherd, Naoki Yamawaki

Nature reviews. Neuroscience, Год журнала: 2021, Номер 22(7), С. 389 - 406

Опубликована: Май 6, 2021

Язык: Английский

Процитировано

191
Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations DOI Creative Commons
Dennis Nestvogel, David A. McCormick

Neuron, Год журнала: 2021, Номер 110(1), С. 120 - 138.e4

Опубликована: Окт. 22, 2021

Язык: Английский

Процитировано

77
Neuroscience and architecture: Modulating behavior through sensorimotor responses to the built environment DOI Creative Commons
Zakaria Djebbara, Ole B. Jensen, Francisco J. Parada

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 138, С. 104715 - 104715

Опубликована: Май 30, 2022

As we move through the world, natural and built environments implicitly guide behavior by appealing to certain sensory motor dynamics. This process can be motivated automatic attention environmental features that resonate with specific sensorimotor responses. review aims at providing a psychobiological framework describing how lead automated responses defined neurophysiological mechanisms underlying attention. Through use of processes in subsets cortical structures, goal this is describe on neuronal level functional link between designed environment By distinguishing elaborate employs for adaptation. realized thalamo-cortical network integrating aspects behavior. We highlight transthalamic transmission from an Enactive predictive perspective recent studies effectively modulated systematically manipulating features. end suggesting promising combination neuroimaging computational analysis future studies.

Язык: Английский

Процитировано

44
On natural attunement: Shared rhythms between the brain and the environment DOI Creative Commons
Efrosini Charalambous, Zakaria Djebbara

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 155, С. 105438 - 105438

Опубликована: Окт. 27, 2023

Rhythms exist both in the embodied brain and built environment. Becoming attuned to rhythms of environment, such as repetitive columns, can greatly affect perception. Here, we explore how environment affects human cognition behavior through concept natural attunement, often resulting from coordination a person's sensory motor systems with rhythmic elements We argue that should not be reduced mere states, representations, single variables but instead considered bundle highly related continuous signals which resonate. Resonance entrainment are dynamic processes observed when intrinsic frequencies oscillatory influenced by oscillations an external signal. This allows visual stimulations body neural entrainment, cross-frequency coupling, phase resetting. review real-world architectural settings dynamics, cognitive processes, people, suggesting crucial role everyday brain-body-environment relationship.

Язык: Английский

Процитировано

26
Cooperative thalamocortical circuit mechanism for sensory prediction errors DOI Creative Commons

Shohei Furutachi,

Alexis D. Franklin, Andreea M. Aldea

и другие.

Nature, Год журнала: 2024, Номер 633(8029), С. 398 - 406

Опубликована: Авг. 28, 2024

Abstract The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and outcomes our actions. Discrepancies between expected actual events, referred errors, are leveraged update guide attention towards unexpected events 1–10 . Despite importance prediction-error signals for various neural computations across brain, surprisingly little is known about circuit mechanisms responsible their implementation. Here we describe thalamocortical disinhibitory that required generating sensory in mouse primary visual cortex (V1). We show violating animals’ predictions by stimulus preferentially boosts responses layer 2/3 V1 neurons most selective stimulus. Prediction errors specifically amplify input, rather than representing non-specific surprise or difference how input deviates from animal’s predictions. This amplification implemented cooperative mechanism requiring thalamic pulvinar cortical vasoactive-intestinal-peptide-expressing (VIP) inhibitory interneurons. In response VIP inhibit specific subpopulation somatostatin-expressing interneurons gate excitatory V1, resulting pulvinar-driven stimulus-selective V1. Therefore, prioritizes unpredicted information selectively increasing salience features through synergistic interaction neocortical circuits.

Язык: Английский

Процитировано

17
Corticothalamic Pathways in Auditory Processing: Recent Advances and Insights From Other Sensory Systems DOI Creative Commons
Flora M. Antunes, Manuel S. Malmierca

Frontiers in Neural Circuits, Год журнала: 2021, Номер 15

Опубликована: Авг. 19, 2021

The corticothalamic (CT) pathways emanate from either Layer 5 (L5) or 6 (L6) of the neocortex and largely outnumber ascending, thalamocortical pathways. CT provide anatomical foundations for an intricate, bidirectional communication between thalamus cortex. They act as dynamic circuits information transfer with ability to modulate even drive response properties target neurons at each synaptic node circuit. L6 feedback enable cortex shape nature its driving inputs, by directly modulating sensory message arriving thalamus. L5 can postsynaptic initiate a transthalamic corticocortical circuit which cortical areas communicate other. For this reason, place heart through hierarchy. Recent evidence goes further suggest that via regulates functional connectivity within across regions, might be engaged in cognition, behavior, perceptual inference. As descending reciprocal context-dependent cortex, we venture projections are particularly interesting context hierarchical inference formulations such those contemplated predictive processing schemes, so far heavily rely on implementations. We discuss recent proposals suggesting thalamus, higher order pathways, could coordinate contextualize hierarchies. will explore these ideas focus auditory system.

Язык: Английский

Процитировано

55
Cortical-subcortical interactions in goal-directed behavior DOI
K. Guadalupe Cruz,

Yi Ning Leow,

Nhat Minh Le

и другие.

Physiological Reviews, Год журнала: 2022, Номер 103(1), С. 347 - 389

Опубликована: Июнь 30, 2022

Flexibly selecting appropriate actions in response to complex, ever-changing environments requires both cortical and subcortical regions, which are typically described as participating a strict hierarchy. In this traditional view, highly specialized circuits allow for efficient responses salient stimuli, at the cost of adaptability context specificity, attributed neocortex. Their interactions often cortex providing top-down command signals structures implement; however, available technologies develop, studies increasingly demonstrate that behavior is represented by brainwide activity even contain early choice, suggesting behavioral functions emerge result different regions interacting truly collaborative networks. review, we discuss field’s evolving understanding how placental mammals interact cooperatively, not only via cortical-subcortical inputs but through bottom-up interactions, especially thalamus. We describe our current circuitry two exemplar structures, superior colliculus striatum, identify information prioritized regions. then functional these form with one another, thalamus, create parallel loops complex networks flow. Finally, challenge classic view modules contained within specific brain regions; instead, propose certain prioritize types over others, subnetworks they form, defined their anatomical connections dynamics, basis true specialization.

Язык: Английский

Процитировано

32
Brain‐wide mapping of inputs to the mouse lateral posterior (LP/Pulvinar) thalamus–anterior cingulate cortex network DOI

Yi Ning Leow,

Blake Zhou, Heather A. Sullivan

и другие.

The Journal of Comparative Neurology, Год журнала: 2022, Номер 530(11), С. 1992 - 2013

Опубликована: Апрель 6, 2022

Abstract The rodent homolog of the primate pulvinar, lateral posterior (LP) thalamus, is extensively interconnected with multiple cortical areas. While these interactions can span entire LP, subdivisions LP are characterized by differential connections specific regions. In particular, medial has reciprocal frontoparietal areas, including anterior cingulate cortex (ACC). ACC plays an integral role in top‐down sensory processing and attentional regulation, likely exerting some functions via LP. However, little known about how interact, information potentially integrated this network. Here, we address gap employing a projection‐specific monosynaptic rabies tracing strategy to delineate brain‐wide inputs bottom‐up LP→ACC ACC→LP neurons. We find that neurons receive from widespread regions, primary higher order motor also extensive subcortical inputs, particularly intermediate deep layers superior colliculus (SC). Sensory largely arise visual addition, integrate cross‐hemispheric prefrontal as well cortex. Our anatomical mapping LP‐ACC pathways provides roadmap for understanding communicate different sources mediate control visuomotor functions.

Язык: Английский

Процитировано

31
Conserved patterns of functional organization between cortex and thalamus in mice DOI Creative Commons
Andrew Miller‐Hansen, S. Murray Sherman

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(21)

Опубликована: Май 19, 2022

Significance Neuroanatomical tracing provides just a partial picture of information flow in the brain, because excitatory synapses are not all equal. Some strongly drive postsynaptic targets to transfer information, whereas others weakly modulate their responsiveness. Here, we show conserved patterns synaptic function across somatosensory and visual thalamocortical circuits mice involving higher-order thalamic nuclei. These nuclei serve as hubs transthalamic or cortico-thalamo-cortical pathways. We report that feedforward systems operate efficiently transmit feedback act target areas. may generalize other brain how methods synapse physiology molecular biology can inform exploration circuitry processing.

Язык: Английский

Процитировано

30
The caudal prethalamus: Inhibitory switchboard for behavioral control? DOI Creative Commons
Alex Fratzl, Sonja B. Hofer

Neuron, Год журнала: 2022, Номер 110(17), С. 2728 - 2742

Опубликована: Сен. 1, 2022

Язык: Английский

Процитировано

29