Thalamocortical contributions to cognitive task activity DOI Creative Commons
Kai Hwang, James M. Shine, Michael W. Cole

et al.

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Dec. 20, 2022

Thalamocortical interaction is a ubiquitous functional motif in the mammalian brain. Previously (Hwang et al., 2021), we reported that lesions to network hubs human thalamus are associated with multi-domain behavioral impairments language, memory, and executive functions. Here, show how task-evoked thalamic activity organized support these broad cognitive abilities. We analyzed magnetic resonance imaging (MRI) data from subjects performed 127 tasks encompassing range of representations. first investigated spatial organization found basis set patterns evoked processing needs each task. Specifically, anterior, medial, posterior-medial exhibit hub-like profiles suggestive participation. These task overlapped interlinking cortical systems. To further determine relevance thalamocortical connectivity, built data-driven model test whether can be used predict activity. The predicted task-specific patterns, outperformed comparison models on cortical, hippocampal, striatal regions. Simulated low-dimensional, multi-task hub regions impaired prediction. This simulation result was supported by neuropsychological patients focal lesions. In summary, our results suggest general organizational principle system supports

Language: Английский

Thalamic regulation of switching between cortical representations enables cognitive flexibility DOI
Rajeev Rikhye, Aditya Gilra, Michael M. Halassa

et al.

Nature Neuroscience, Journal Year: 2018, Volume and Issue: 21(12), P. 1753 - 1763

Published: Nov. 8, 2018

Language: Английский

Citations

272
Thalamocortical Circuit Motifs: A General Framework DOI Creative Commons
Michael M. Halassa, S. Murray Sherman

Neuron, Journal Year: 2019, Volume and Issue: 103(5), P. 762 - 770

Published: Sept. 1, 2019

Language: Английский

Citations

271
The impact of the human thalamus on brain-wide information processing DOI
James M. Shine, Laura D. Lewis, Douglas D. Garrett

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(7), P. 416 - 430

Published: May 26, 2023

Language: Английский

Citations

130
Mechanisms of distributed working memory in a large-scale network of macaque neocortex DOI Creative Commons
Jorge F. Mejías, Xiao‐Jing Wang

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Feb. 24, 2022

Neural activity underlying working memory is not a local phenomenon but distributed across multiple brain regions. To elucidate the circuit mechanism of such activity, we developed an anatomically constrained computational model large-scale macaque cortex. We found that mnemonic internal states may emerge from inter-areal reverberation, even in regime where none isolated areas capable generating self-sustained activity. The pattern along cortical hierarchy indicates transition space, separating engaged and those which do not. A host spatially distinct attractor found, potentially subserving various processes. yields testable predictions, including idea counterstream inhibitory bias, role prefrontal controlling attractors, resilience to lesions or inactivation. This work provides theoretical framework for identifying mechanisms principles cognitive

Language: Английский

Citations

109
The mediodorsal thalamus in executive control DOI
Mathieu Wolff, Michael M. Halassa

Neuron, Journal Year: 2024, Volume and Issue: 112(6), P. 893 - 908

Published: Jan. 30, 2024

Language: Английский

Citations

22
Principles of Corticocortical Communication: Proposed Schemes and Design Considerations DOI
Adam Kohn,

Anna I. Jasper,

João D. Semedo

et al.

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 43(9), P. 725 - 737

Published: Aug. 5, 2020

Language: Английский

Citations

91
Visual intracortical and transthalamic pathways carry distinct information to cortical areas DOI Creative Commons
Antonin Blot, Morgane Roth,

Ioana T. Gasler

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(12), P. 1996 - 2008.e6

Published: May 11, 2021

Sensory processing involves information flow between neocortical areas, assumed to rely on direct intracortical projections. However, cortical areas may also communicate indirectly via higher-order nuclei in the thalamus, such as pulvinar or lateral posterior nucleus (LP) visual system of rodents. The fine-scale organization and function these cortico-thalamo-cortical pathways remains unclear. We find that responses mouse LP neurons projecting higher likely derive from feedforward input primary cortex (V1) combined with many subcortical including superior colliculus. Signals projections different are tuned specific features stimuli their locomotor context, distinct signals carried by V1. Thus, transthalamic functionally target, pathways, combine multiple brain regions, linking sensory behavioral context.

Language: Английский

Citations

90
Context-dependent and dynamic functional influence of corticothalamic pathways to first- and higher-order visual thalamus DOI Open Access
Megan A. Kirchgessner, Alexis D. Franklin, Edward M. Callaway

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(23), P. 13066 - 13077

Published: May 27, 2020

Layer 6 (L6) is the sole purveyor of corticothalamic (CT) feedback to first-order thalamus and also sends projections higher-order thalamus, yet how it engages full circuit contribute sensory processing in an awake animal remains unknown. We sought elucidate functional impact L6CT from primary visual cortex dorsolateral geniculate nucleus (first-order) pulvinar (higher-order) using optogenetics extracellular electrophysiology mice. While sustained photostimulation suppresses activity both thalamic nuclei vivo, moderate-frequency (10 Hz) stimulation powerfully facilitates spiking. show that each paradigm differentially influences balance between monosynaptic excitatory disynaptic inhibitory pathways pulvinar, as well prevalence burst versus tonic firing. Altogether, our results support a model which L6CTs modulate first- through parallel are highly dynamic context-dependent.

Language: Английский

Citations

89
A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex DOI Creative Commons
Seán Froudist‐Walsh,

Daniel P. Bliss,

Xingyu Ding

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(21), P. 3500 - 3520.e13

Published: Sept. 17, 2021

Dopamine is required for working memory, but how it modulates the large-scale cortex unknown. Here, we report that dopamine receptor density per neuron, measured by autoradiography, displays a macroscopic gradient along macaque cortical hierarchy. This incorporated in connectome-based model endowed with multiple neuron types. The captures an inverted U-shaped dependence of memory on and spatial patterns persistent activity observed over 90 experimental studies. Moreover, show crucial filtering out irrelevant stimuli enhancing inhibition from dendrite-targeting interneurons. Our revealed activity-silent trace can be realized facilitation inter-areal connections adjusting induces switch this internal state to distributed activity. work represents cross-level understanding molecules cell types recurrent circuit dynamics underlying core cognitive function across primate cortex.

Language: Английский

Citations

87
Thalamocortical excitability modulation guides human perception under uncertainty DOI Creative Commons
Julian Q. Kosciessa, Ulman Lindenberger, Douglas D. Garrett

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 23, 2021

Abstract Knowledge about the relevance of environmental features can guide stimulus processing. However, it remains unclear how processing is adjusted when feature uncertain. We hypothesized that (a) heightened uncertainty would shift cortical networks from a rhythmic, selective processing-oriented state toward an asynchronous (“excited”) boosts sensitivity to all features, and (b) thalamus provides subcortical nexus for such uncertainty-related shifts. Here, we had young adults attend varying numbers task-relevant during EEG fMRI acquisition test these hypotheses. Behavioral modeling electrophysiological signatures revealed greater lowered rate evidence accumulation individual shifted cortex rhythmic asynchronous/excited regime, neuromodulatory arousal. Crucially, this unified constellation within-person effects was dominantly reflected in uncertainty-driven upregulation thalamic activity. argue processes involving play central role brain modulates neural excitability face momentary uncertainty.

Language: Английский

Citations

83